Oct4 reduction contributes to testicular injury of unilateral testicular torsion in mice model and apoptotic death of Sertoli cells through mediating CIP2A expression

Zhang, Haochuan; Zhu, Yunlong; Jin, Chengli; Shi, Lingxin; Xie, Yuan; Sun, Xiance; Li, Peizhen; Zhu, Xinyi; Dai, Quanquan; Yang, Fan; Xie, Xiaoxiao; Qin, Le

doi:10.1016/j.gene.2023.147214

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Role Of Nrf2 In Female and Male Infertility Disorders1

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2024

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“…The octamer-binding transcription factor 4 (Oct4)-cancerous inhibitors of protein phosphatase 2A (CIP2A) axis are considered to be another pathway that increases the antioxidant defense system in spermatic cord torsion/detorsion by activating the Nrf2-HO-1-NQO1 pathway [ 119 ]. Overexpression of the transcription factor Oct4 increases the expression of its downstream gene CIP2A in Leydig, Sertoli, and germ cells, leading to the activation Nrf2 [ 120 ]. Examining microRNAs expression in the testicular tissue of rats with testicular I/R injury shows the upregulated level of miR-101-3p, leading to the downregulation of Nrf2, GST, NQO1, and HO-1 levels.…”

Section: Role Of Nrf2 In Female and Male Infertility Disordersmentioning

confidence: 99%