Octahedral molybdenum cluster as a photoactive antimicrobial additive to a fluoroplastic

Abstract

Finding methods that fight bacterial infection or contamination, while minimising our reliance on antibiotics is one of the most pressing needs of this century. Although the utilisation of UV-C light and strong oxidising agents, such as bleach, are still efficacious methods for eliminating bacterial surface contamination, both methods present severe health and/or environmental hazards. Materials with intrinsic photodynamic activity (i.e. a A c c e p t e d m a n u s c r i p t material's ability upon photoexcitation to convert molecular oxygen into reactive oxygen species such as singlet oxygen), which work with light within the visible photomagnetic spectrum could offer a significantly safer alternative. Here we present a new, bespoke molybdenum cluster (Bu4N)2[Mo6I8(n-C7F15COO)6], which is both efficient in the generation of singlet oxygen upon photoirradiation and compatible with the fluoropolymer (F23-L) known for its good oxygen permeability. Thus, (Bu4N)2[Mo6I8(n-C7F15COO)6]/F23-L mixtures have been solution-processed to give homogenous films of smooth and fibrous morphologies and which displayed high photoinduced antibacterial activity against four common pathogens under visible light irradiation. These materials thus have potential in applications ranging from antibacterial coatings to filtration membranes and air conditioners to prevent spread of bacterial infections.

Hexasubstituted Iodide Tungsten Cluster Complexes with Azide and Isothiocyanate Ligands

“…As mentioned earlier, octahedral halide clusters can act as photosensitizers in the singlet oxygen generation processes,, , which leads to strong quenching of luminescence emission intensity and decreasing of the photophysical parameters. In order to demonstrate this effect in the case of the titled compounds, molecular oxygen was removed from the cluster complex solutions by saturation with Ar.…”

“…), which explains much attention of the researchers to this class of compounds . Moreover, the ability of the clusters to photosensitize the process of singlet oxygen generation expands the area of possible applications from wastewater treatment to photodynamic therapy,, which determines the importance of further development of cluster chemistry. However, despite structural and physicochemical similarities of molybdenum and tungsten cluster complexes, coordination chemistry of W 6 ‐clusters has been much less studied.…”

Photodynamic Inactivation of Staphylococcus aureus Biofilms Using a Hexanuclear Molybdenum Complex Embedded in Transparent polyHEMA Hydrogels

“…aureus, Salmonella typhimurium, and P. aeruginosa upon irradiation . It must be noted that all the above-mentioned investigations report bacteria in the planktonic state.…”

Electrophoretically Deposited Layers of Octahedral Molybdenum Cluster Complexes: A Promising Coating for Mitigation of Pathogenic Bacterial Biofilms under Blue Light

“…5 This sensitization ability has been exploited for the design of various functional materials for photodegradation of pollutants, 6 photo/radiosensitized killing of tumor cells, 5,7,8,9,10,11,12 or photodynamic inactivation of bacteria. 13,14,15,16 The high efficacy of this modality in photoinactivation of bacteria stems from the fact that O 2 ( 1  g ) attacks several critical targets of pathogens, thus making their resistance unlikely.…”

“…13,14 Shestopalov et al investigated the antibacterial activity of fluorinated polymer films immobilized cluster complexes. 15,17 Our group recently reported the photoinactivation properties of a positively charged Mo 6 complex. 16 However, the more challenging, not yet achieved with Mo 6 complexes, is the photodynamic inactivation of microbial biofilms.…”