Octopamine and Dopamine differentially modulate the nicotine-induced calcium response in Drosophila Mushroom Body Kenyon Cells

Leyton, Vilma; Goles, N.I.; Fuenzalida‐Uribe, Nicolás; Campusano, Jorge M.

doi:10.1016/j.neulet.2013.12.006

Cited by 10 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, previous work demonstrated a role for the rdl (GABA) receptor in memory formation (Liu et al, 2007), and we found this receptor is expressed strongly in both the KCs and V2 MBONs. Nicotinic AchR calcium currents and fast excitatory synaptic transmission are known to be modulated in Drosophila and honeybees by octopamine and dopamine signaling (Dupuis et al, 2012; Leyton et al, 2014) but determining the expression of specific nAchR subunits has been difficult. Here, we observed a diverse range of subunits expressed in different MB neurons.…”

Section: Resultsmentioning

confidence: 99%

Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression

et al. 2016

View full text Add to dashboard Cite

Summary Learning and memory formation in Drosophila rely on a network of neurons in the mushroom bodies (MB). While numerous studies have delineated roles for individual cell types within this network in aspects of learning or memory, whether or not these cells can also be distinguished by the genes they express remains unresolved. In addition, the changes in gene expression that accompany long-term memory formation within the MBs have not yet been studied by neuron type. Here we address both issues by performing RNA sequencing on single cell types (harvested via patch pipets) within the MB. We discover that the expression of genes that encode cell surface receptors is sufficient to identify cell types, and that a subset of these genes, required for sensory transduction in peripheral sensory neurons, are not only expressed within individual neurons of the MB in the central brain, but are also critical for memory formation.

show abstract

Section: Resultsmentioning

confidence: 99%

Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Octopamine is a vital regulatory biogenic amine in invertebrates and acts through metabotropic octopamine G-protein-coupled receptors (Beggs et al, 2011;Evans and Maqueira, 2005). It has been demonstrated that the activation of the octopamine receptors lead to the modification of proteins that can serve as targets for chemical insecticides (Leyton et al, 2014;Reale et al, 1986;Vehovszky et al, 2004Vehovszky et al, , 2005. In experiments performed on mosquitoes, positive synergistic effects have been demonstrated between the activators of the octopamine receptors (formamidines) and different insecticide groups (pyrethroids, neonicotinoids, organophosphorus and insect growth regulators) (Ahmed and Matsumura, 2012;Vogel, 2015, 2016).…”

Section: Introductionmentioning

confidence: 99%

The unusual action of essential oil component, menthol, in potentiating the effect of the carbamate insecticide, bendiocarb

Jankowska

Lapied

Jankowski

et al. 2019

Pesticide Biochemistry and Physiology

View full text Add to dashboard Cite

“…As previously reported [93, 94]. In brief, fly brains were dissected out of the animals at pupal stage P9, in dissecting solution (DS), consisting of 6.85 mM NaCl, 0.27 mM KCl, 0.009 mM Na2HPO4, 0.001 mM KH2PO4, 0.2772 mM HEPES, pH 7.4.…”

Section: Methodsmentioning

confidence: 99%

Lipophorin receptors regulate mushroom bodies development and participate in learning, memory and sleep in flies

Rojo-Cortés

Tapia-Valladares

Fuenzalida‐Uribe

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundDrosophila melanogaster Lipophorin Receptors (LpRs), LpR1 and LpR2, mediate lipid uptake. The orthologs of these receptors in vertebrates, ApoER2 and VLDL-R, bind Reelin, a glycoprotein not present in flies. These receptors are associated with the development and function of the hippocampus and cerebral cortex, important association areas in the mammalian brain. It is currently unknown whether LpRs play similar roles in the Drosophila brain.ResultsWe report that LpR-deficient flies exhibit impaired olfactory memory and sleep patterns, which seem to reflect anatomical defects found in a critical brain association area, the Mushroom Bodies (MB). Moreover, cultured MB neurons respond to mammalian Reelin by increasing the complexity of their neurites. This effect depends on LpRs and Dab, the Drosophila ortholog of the reelin signaling adaptor protein Dab1. In vitro, two of the long isoforms of LpRs allow the internalization of Reelin.ConclusionsThese findings demonstrate that LpRs contribute to MB development and function, supporting the existence of LpR-dependent signaling in Drosophila.

show abstract

Octopamine and Dopamine differentially modulate the nicotine-induced calcium response in Drosophila Mushroom Body Kenyon Cells

Cited by 10 publications

References 34 publications

Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression

Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression

The unusual action of essential oil component, menthol, in potentiating the effect of the carbamate insecticide, bendiocarb

Lipophorin receptors regulate mushroom bodies development and participate in learning, memory and sleep in flies

Contact Info

Product

Resources

About