Octopamine receptors in the honey bee and locust nervous system: pharmacological similarities between homologous receptors of distantly related species

Degen, J.; Gewecke, Michael; Roeder, Thomas

doi:10.1038/sj.bjp.0703338

Cited by 57 publications

(55 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar observations have been reported for insect TA/OA receptors (Saudou et al, 1990;Vanden Broeck et al, 1995;Degen et al, 2000). Therefore, the preincubation conditions used in the present study may allow these ligands to accumulate to levels sufficient to activate the other receptors.…”

Section: Preexposure To Exogenous Ta or Oa Abolishes Ta/oa Inhibitionsupporting

confidence: 73%

Tyramine and Octopamine Independently Inhibit Serotonin-Stimulated Aversive Behaviors inCaenorhabditis elegansthrough Two Novel Amine Receptors

Wragg¹,

Hapiak²,

Miller³

et al. 2007

J. Neurosci.

115

146

View full text Add to dashboard Cite

Biogenic amines modulate key behaviors in both vertebrates and invertebrates. In Caenorhabditis elegans, tyramine (TA) and octopamine (OA) inhibit aversive responses to 100%, but not dilute (30%) octanol. TA and OA also abolish food-and serotonin-dependent increases in responses to dilute octanol in wild-type but not tyra-3(ok325) and f14d12.6(ok371) null animals, respectively, suggesting that TA and OA modulated responses to dilute octanol are mediated by separate, previously uncharacterized, G-protein-coupled receptors. TA and OA are high-affinity ligands for TYRA-3 and F14D12.6, respectively, based on their pharmacological characterization after heterologous expression. f14d12.6::gfp is expressed in the ASHs, the neurons responsible for sensitivity to dilute octanol, and the sra-6-dependent expression of F14D12.6 in the ASHs is sufficient to rescue OA sensitivity in f14d12.6(ok371) null animals. In contrast, tyra-3::gfp appears not to be expressed in the ASHs, but instead in other neurons, including the dopaminergic CEP/ADEs. However, although dopamine (DA) also inhibits 5-HT-dependent responses to dilute octanol, TA still inhibits in dop-2; dop-1; dop-3 animals that do not respond to DA and cat-2(tm346) and Pdat-1::ICE animals that lack significant dopaminergic signaling, suggesting that DA is not an intermediate in TA inhibition. Finally, responses to TA and OA selectively desensitize after preexposure to the amines. Our data suggest that although tyraminergic and octopaminergic signaling yield identical phenotypes in these olfactory assays, they act independently through distinct receptors to modulate the ASH-mediated locomotory circuit and that C. elegans is a useful model to study the aminergic modulation of sensory-mediated locomotory behaviors.

show abstract

Section: Preexposure To Exogenous Ta or Oa Abolishes Ta/oa Inhibitionsupporting

confidence: 73%

Tyramine and Octopamine Independently Inhibit Serotonin-Stimulated Aversive Behaviors inCaenorhabditis elegansthrough Two Novel Amine Receptors

Wragg¹,

Hapiak²,

Miller³

et al. 2007

J. Neurosci.

115

146

View full text Add to dashboard Cite

show abstract

“…The large body of biochemical, pharmacological, and physiological evidence collected over the course of almost 100 years convincingly demonstrates the presence of endogenous TAs in all species of invertebrates (de Rome et al, 1980;Degen et al, 2000;Dudai, 1982;Dudai & Zvi, 1984;Guillen et al, 1989;Hashemzadeh et al, 1985;Rex & Komuniecki, 2002) and vertebrates that have been examined (Molinoff & Axelrod, 1969;Molinoff & Axelrod, 1972;Durden et al, 1973;Philips et al, 1974a;Philips et al, 1974b;Saavedra et al, 1974;Juorio, 1976;Juorio & Philips, 1976;Juorio & Robertson, 1977;Philips et al, 1978;Reynolds et al, 1980;Juorio & Kazakoff, 1984;Williams et al, 1987;Juorio & Sloley, 1988;Downer et al, 1993).…”

Section: Historic Contextmentioning

confidence: 99%

Trace amine-associated receptor 1—Family archetype or iconoclast?

Grandy

2007

Pharmacology & Therapeutics

179

211

View full text Add to dashboard Cite

Interest has recently been rekindled in receptors that are activated by low molecular weight, noncatecholic, biogenic amines that are typically found as trace constituents of various vertebrate and invertebrate tissues and fluids. The timing of this resurgent focus on receptors activated by the 'trace amines' (TAs) β-phenylethylamine (PEA), tyramine (TYR), octopamine (OCT), synephrine (SYN), and tryptamine (TRYP) is the direct result of two publications that appeared in 2001 describing the cloning of a novel G protein-coupled receptor (GPCR) referred to by their discoverers as TA1 (Borowsky et al., 2001) and TAR1 (Bunzow et al., 2001). When heterologously expressed in Xenopus laevis oocytes and various eukaryotic cell lines recombinant rodent and human TA receptors dosedependently couple to the stimulation of cAMP production. Structure-activity profiling based on this functional response has revealed that in addition to the TAs, other biologically active compounds containing a 2 carbon aliphatic side chain linking an amino group to at least one benzene ring are potent and efficacious TA receptor agonists with amphetamine, methamphetamine, 3-iodothyronamine, thyronamine, and dopamine among the most notable. Almost 100 years after the search for TA receptors began numerous TA1/TAR1-related sequences, now called Trace AmineAssociated Receptors (TAARs), have been identified in the genome of every species of vertebrate examined to date. Consequently, even though heterologously expressed TAAR1 fits the pharmacological criteria established for a bona fide TA receptor a major challenge for those working in the field is to discern the in vivo pharmacology and physiology of each purported member of this extended family of GPCRs. Only then will it be possible to establish whether TAAR1 is the family archetype or an iconoclast.

show abstract

“…Epinastine, a highly specific and selective antagonist of insect neuronal octopamine receptors (Roeder et al, 1998, Degen et al, 2000, blocked the effect of flying on the evaluated parameters of cricket aggressive behavior (Fig. 7, black bars).…”

Section: Octopamine Receptor Antagonists and Aggressionmentioning

confidence: 99%

“…7), a highly specific neuronal octopamine receptor antagonist in insects with low affinity for other amine receptors (Roeder et al, 1998). The dosage we applied is the lowest that blocks putative octopaminergic modulation of neuronal responses in insects (Roeder et al, 1998;Degen et al, 2000;Spivak et al, 2003). Because insect octopamine receptors are pharmacologically homologous to mammalian ␣-adrenoceptors (Evans, 1981(Evans, , 1985Evans and Robb, 1993;Roeder, 1995), our finding that the flight effect was blocked by the ␣-blocker phentolamine, but not by the ␤-blocker propranolol, supports our suggestion that flight enhances aggression by inducing octopamine release.…”

Section: Octopamine Receptor Antagonistsmentioning

confidence: 99%

Octopamine and Experience-Dependent Modulation of Aggression in Crickets

Stevenson¹,

Dyakonova²,

Rillich³

et al. 2005

J. Neurosci.

217

216

View full text Add to dashboard Cite

Intraspecific aggression is influenced in numerous animal groups by the previous behavioral experiences of the competitors. The underlying mechanisms are, however, mostly obscure. We present evidence that a form of experience-dependent plasticity of aggression in crickets is mediated by octopamine, the invertebrate counterpart of noradrenaline. In a forced-fight paradigm, the experience of flying maximized the aggressiveness of crickets at their first encounter and accelerated the subsequent recovery of aggressiveness of the normally submissive losers, without enhancing general excitability as evaluated from the animals' startle responses to wind stimulation. This effect is transitory and concurrent with the activation of the octopaminergic system that accompanies flight. Hemocoel injections of the octopamine agonist chlordimeform (CDM) had similar effects on aggression but also enhanced startle responses. Serotonin depletion, achieved using ␣-methyl-tryptophan, enhanced startle responses without influencing aggression, indicating that the effect of CDM on aggression is not attributable to increased general excitation. Contrasting this, aggressiveness was depressed, and the effect of flying was essentially abolished, in crickets depleted of octopamine and dopamine using ␣-methyl-p-tyrosine (AMT). CDM restored aggressiveness in AMT-treated crickets, indicating that their depressed aggressiveness is attributable to octopamine depletion rather than to dopamine depletion or nonspecific defects. Finally, the flight effect was blocked in crickets treated with the octopamine receptor antagonist epinastine, or with the ␣-adrenoceptor and octopamine receptor antagonist phentolamine, but not with the ␤-adrenoceptor antagonist propranolol. The idea that activity-specific induction of the octopaminergic system underlies other forms of experiencedependent plasticity of aggressive motivation in insects is discussed.

show abstract

Octopamine receptors in the honey bee and locust nervous system: pharmacological similarities between homologous receptors of distantly related species

Cited by 57 publications

References 42 publications

Tyramine and Octopamine Independently Inhibit Serotonin-Stimulated Aversive Behaviors inCaenorhabditis elegansthrough Two Novel Amine Receptors

Tyramine and Octopamine Independently Inhibit Serotonin-Stimulated Aversive Behaviors inCaenorhabditis elegansthrough Two Novel Amine Receptors

Trace amine-associated receptor 1—Family archetype or iconoclast?

Octopamine and Experience-Dependent Modulation of Aggression in Crickets

Contact Info

Product

Resources

About