Ocular Adnexal Lymphomas: Single-Center Experience

Özkan, Melda Cömert; Palamar, Melis; Tombuloğlu, Murat; Hekımgıl, Mıne; Özsan, Nazan; Saydam, Güray; Şahin, Fahri

doi:10.1016/j.clml.2015.02.015

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…In recent years, with the increasing level of diagnosis, the incidence of OALs has been increasing year by year, with the incidence increasing by 6% to 6.5% per year. 9 However, the pathogenesis of OAL is still unclear, and it is multifactorial, related to clonal expansion of lymphocytes induced by persistent antigenic stimulation of chronic inflammation, 22 autoimmune diseases, or pathogenic infections (e.g., EBV, Helicobacter pylori, or Chlamydia psittaci). 23,24 In this study, 31 patients underwent in situ hybridization for EBERs, and 4 cases were positive, all of which were TCL, suggesting that TCL is related to EBV infection, and it is hypothesized that EBV infection may be one of the causes of the pathogenesis of TCL, and the relationship between the occurrence of other types of OALs and pathogenic infections still needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

“…OALs are common malignant tumors of the eye, which can involve the orbital and eyelid as well as the conjunctiva, etc. In recent years, with the increasing level of diagnosis, the incidence of OALs has been increasing year by year, with the incidence increasing by 6% to 6.5% per year 9 . However, the pathogenesis of OAL is still unclear, and it is multifactorial, related to clonal expansion of lymphocytes induced by persistent antigenic stimulation of chronic inflammation, 22 autoimmune diseases, or pathogenic infections (e.g., EBV, Helicobacter pylori, or Chlamydia psittaci) 23,24 .…”

Section: Discussionmentioning

confidence: 99%

“…OALs constitute 5%–15% of all extranodal lymphomas 7,8 . In recent years, the incidence of this disease has been increasing, and it is now the leading accessory malignancy in adult eyes 9 . OALs are mostly observed in people aged 50–70 years, with a median age of 65 years, and are more common in females than males in Western countries, with a male‐to‐female ratio of 1.5–2:1 10–13 .…”

Section: Introductionmentioning

confidence: 99%

“…7,8 In recent years, the incidence of this disease has been increasing, and it is now the leading accessory malignancy in adult eyes. 9 OALs are mostly observed in people aged 50-70 years, with a median age of 65 years, and are more common in females than males in Western countries, with a male-to-female ratio of 1.5-2:1. [10][11][12][13] The most commonly affected sites are the orbit (40%), followed by the conjunctiva (35%-40%), lacrimal gland (10%-15%), and eyelid (10%).…”

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confidence: 99%

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Clinical analysis of 94 cases of ocular adnexal lymphomas

Sun,

Luo,

Huang

2024

Precision Medical Sciences

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To investigate the imaging manifestations and pathological features of ocular adnexal lymphoma (OALs) in order to provide relevant information for ophthalmologists. A total of 94 patients with OALs were pathologically confirmed between August 2018 and July 2023, and their demographics, location, subtype, treatment, and prognosis were retrospectively studied. 94 patients with OALs were included in this study, of whom 28 were female (29.79%) and 66 were male (70.21%). The age of the patients ranged from 21 to 80 years, with a predominance of 50–60 years (60/94); monocular onset was common (90/94), and the most site of onset was orbital (74/94), followed by conjunctiva (12/94), eyelids (4/94), vitreous (3/94), and lacrimal gland (1/94). CT and MRI can show the involvement and extent of the lesions, and the pathology of the disease is characterized by mucosa‐associated lymphoid tissue marginal zone B‐cell lymphoma (72/94), diffuse large B‐cell lymphoma (10/94), T‐cell lymphoma (4/94), mantle cell lymphoma (2/94), Burkitt's lymphoma (2/94), small lymphocytic lymphoma (2/94), and follicular lymphoma (1/94). All patients received surgical treatment, 42 patients received local radiation therapy, 35 patients received chemotherapy, 13 patients received radiation therapy and chemotherapy successively, and 3 patients received comprehensive treatment. During the follow‐up, three patients relapsed, four died, one was lost to follow‐up, and the remaining patients had stable conditions. The majority of OALs are mucosa‐associated lymphoid tissue marginal zone B‐cell lymphomas (MALT) with an excellent prognosis. It mostly occurs in people over 50 years of age and most site of the onset is orbital.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical analysis of 94 cases of ocular adnexal lymphomas

Sun,

Luo,

Huang

2024

Precision Medical Sciences

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“…Non-Hodgkin lymphoma (NHL) of the orbit and ocular adnexa is the most common primary orbital malignancy 1,2. In recent years, the incidence of orbital and ocular adnexal NHL has been increasing 3. As we know, NHL constitutes a group of very heterogeneous neoplasms, deriving from a clonal proliferation of B or T lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of valosin-containing protein (VCP) is associated with poor prognosis and promotes tumor progression of orbital B-cell lymphoma

Zhu

Xiao

2018

OTT

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ObjectiveThis study aimed to investigate the relationship between VCP expression and the prognosis of orbital B-cell lymphoma patients and the influence of downregulation of VCP on the apoptosis and invasion abilities of lymphoma cells.MethodsWe recruited 66 orbital B-cell lymphoma patients. VCP expression in 66 samples of orbital B-cell lymphoma was determined by immunohistochemistry using monoclonal VCP antibodies. Based on VCP-expression levels detected by immunohistochemistry, we chose ten cases of orbital tumor paraffin tissue from the patients. Total RNA was extracted and differences in VCP gene-expression levels compared among patients using quantitative reverse-transcription (qRT) PCR. We used siRNA to knock down VCP in the lymphoma cell lines Raji and SUDHL4. qRT-PCR and Western blot were applied to detect VCP mRNA and protein expression, respectively. SUDHL48 assays were applied to investigate cell proliferation. Hoechst 33258 staining and flow-cytometry analysis were applied to investigate cell apoptosis. Transwell assays were applied to investigate invasive ability. Survival analysis was used to evaluate prognostic values.ResultsExpression levels of VCP were correlated with the stage, tumor grade, and recurrence rate of patients. VCP mRNA-expression levels were consistent with VCP-expression levels in orbital B-cell lymphoma tissue. Moreover, survival analysis revealed that lower VCP-expression levels were correlated with longer overall survival of orbital B-cell lymphoma patients. Down-regulation of VCP with siRNA did not inhibit cell proliferation. However, it dramatically increased apoptosis and suppressed the invasion of B-cell lymphoma cells.ConclusionVCP expression played an important role in the progression of orbital B-cell lymphoma. VCP could be a useful marker for predicting the prognosis of orbital B-cell lymphoma patients. VCP may be a potential therapeutic target for orbital B-cell lymphoma.

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Ocular Adnexal Lymphoma: Clinical Presentation and Imaging Studies

Bejjanki

Kaliki

2023

Essentials in Ophthalmology

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Ocular Adnexal Lymphomas: Single-Center Experience

Cited by 5 publications

References 21 publications

Clinical analysis of 94 cases of ocular adnexal lymphomas

Clinical analysis of 94 cases of ocular adnexal lymphomas

Upregulation of valosin-containing protein (VCP) is associated with poor prognosis and promotes tumor progression of orbital B-cell lymphoma

Ocular Adnexal Lymphoma: Clinical Presentation and Imaging Studies

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