Ocular adnexal manifestations of neuroendocrine neoplasms: a case report and a major review

Hatsis, Alexander; Henry, Roger; Curtis, Mark; Bilyk, Jurij R.; Sivalingam, Meera D; Eagle, Ralph C.; Milman, Tatyana

doi:10.1080/01676830.2020.1839108

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…Clinical and prognostic data are overall in keeping with the most recent reviews on the same topic. 13,49,50 Here we have described a rare case of orbital involvement from an ileal carcinoid to contribute to the current sparse evidence of such metastases presenting as incidental finding in asymptomatic patients with unknown primary NET. This is also the most updated literature review of all the published cases of orbital NET metastases to date.…”

Section: Discussionmentioning

confidence: 88%

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Orbital metastasis from neuroendocrine tumour: Case report and literature review

Albanese

Harieaswar

Sampath

2021

European Journal of Ophthalmology

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Orbital metastases from neuroendocrine tumour are rare entities. An incidental finding of orbital metastasis originating from neuroendocrine tumour is presented in the context of a comprehensive review of all case reports and series published to date. Demographics, clinical features, diagnostic work-up, treatment and prognostic data from the published literature are discussed. Ninety-five patients with orbital metastases from neuroendocrine tumours have been reported so far. Average age at presentation is 63.8 years (range 25–86), with no significant gender predominance. Gastrointestinal tract is the most common site of primary neuroendocrine tumours (62–85%). Typical presentation includes proptosis (80–85%) and diplopia (27–62%) in patients with known primary neuroendocrine tumour elsewhere. Histological subtype and presence of metastases seem to be important prognostic factors. Incidental finding of neuroendocrine tumour mestastases in asymptomatic patients with unknown primary disease is uncommon. In such cases, orbital biopsy and structural and functional imaging are essential to establish a diagnosis and stage the disease.

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Section: Discussionmentioning

confidence: 88%

“…Clinical and prognostic data are overall in keeping with the most recent reviews on the same topic. 13,49,50…”

Section: Discussionmentioning

confidence: 99%

Orbital metastasis from neuroendocrine tumour: Case report and literature review

Albanese

Harieaswar

Sampath

2021

European Journal of Ophthalmology

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“…Although GEP NENs typically metastasize to the lymph nodes, liver, and bones, orbital metastases via hematogenous spread through the carotid or ophthalmic arteries are possible, although rarely documented 5–7 . Ocular metastases secondary to NENs are atypical, with a total of approximately 20 cases reported in the literature 8,9 . However, when discovered, they may serve as an indicator of a more occult neoplasm.…”

mentioning

confidence: 99%

A Case Series of Choroidal and Orbital Neuroendocrine Tumors: Metastasis

Zhuang,

Bergstrom,

El-Rayes

et al. 2024

Pancreas

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Neuroendocrine tumors are rare cancers with heterogenous histologies, response to treatments and prognoses. Majority of these cancers originate in the gastrointestinal tract and metastasize to the liver. We are reporting 5 patients with low-grade neuroendocrine tumor disease with rare metastases to the choroids. Two of the patients were treated with peptide receptor radionuclide therapy (Lutitium-177). This is the first report confirming PRRT safety in patients with low grade NET with ocular metastases.

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Extraocular muscle enlargement

Rana

Juniat

Patel

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Extraocular muscle enlargement can occur secondary to a range of orbital and systemic diseases. Although the most common cause of extraocular muscle enlargement is thyroid eye disease, a range of other inflammatory, infective, neoplastic, and vascular conditions can alter the size and shape of the extraocular muscles. Imaging with computed tomography and magnetic resonance imaging plays an essential role in the workup of these conditions. This article provides an image-rich review of the wide range of pathology that can cause enlargement of the extraocular muscles.

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Ocular adnexal manifestations of neuroendocrine neoplasms: a case report and a major review

Cited by 5 publications

References 57 publications

Orbital metastasis from neuroendocrine tumour: Case report and literature review

Orbital metastasis from neuroendocrine tumour: Case report and literature review

A Case Series of Choroidal and Orbital Neuroendocrine Tumors: Metastasis

Extraocular muscle enlargement

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