Ocular and concomitant cutaneous sporotrichosis

Vieira-Dias, D.; Sena, Claudio Maciel; Oréfice, Fernando; Tanure, Marco Antônio Guarino; Hamdan, Júnia Soares

doi:10.1111/j.1439-0507.1997.tb00214.x

Cited by 32 publications

(33 citation statements)

References 12 publications

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“…In immunocompromised individuals, mainly in HIV + patients and alcoholics, the pulmonary and articular forms of sporotrichosis are the most frequent clinical manifestations (5,26). This fungus was also recently isolated from aqueous humor (27). Since this apparent tropism of S. schenckii may be associated with the ability to recognize specific ECM components, we investigated binding of this pathogen to type II collagen.…”

Section: Discussionmentioning

confidence: 99%

Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins

Lima

Figueiredo²,

Pereira³

et al. 1999

Braz J Med Biol Res

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The pathogenic fungus Sporothrix schenckii is the causative agent of sporotrichosis. This subcutaneous mycosis may disseminate in immunocompromised individuals and also affect several internal organs and tissues, most commonly the bone, joints and lung. Since adhesion is the first step involved with the dissemination of pathogens in the host, we have studied the interaction between S. schenckii and several extracellular matrix (ECM) proteins. The binding of two morphological phases of S. schenckii, yeast cells and conidia, to immobilized type II collagen, laminin, fibronectin, fibrinogen and thrombospondin was investigated. Poly (2-hydroxyethyl methacrylate) (poly-HEMA) was used as the negative control. Cell adhesion was assessed by ELISA with a rabbit anti-S. schenckii antiserum. The results indicate that both morphological phases of this fungus can bind significantly to type II collagen, fibronectin and laminin in comparison to the binding observed with BSA (used as blocking agent). The adhesion rate observed with the ECM proteins (type II collagen, fibronectin and laminin) was statistically significant (P<0.05) when compared to the adhesion obtained with BSA. No significant binding of conidia was observed to either fibrinogen or thrombospondin, but yeast cells did bind to the fibrinogen. Our results indicate that S. schenckii can bind to fibronectin, laminin and type II collagen and also show differences in binding capacity according to the morphological form of the fungus.

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Section: Discussionmentioning

confidence: 99%

Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins

Lima

Figueiredo²,

Pereira³

et al. 1999

Braz J Med Biol Res

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“…Until 1990, 17 episodes of endophthalmitis due to S. schenckii had been reported (427). Since then, there have been additional reports of S. schenckii causing endophthalmitis (52,427) and uveitis (410). Vieira-Dias et al (410) reported the occurrence of concomitant ocular and cutaneous sporotrichosis, in which the fungus was isolated from skin lesions and the aqueous humor.…”

Section: Intraocular Mycoses (Excluding Endophthalmitis)mentioning

confidence: 99%

“…Since then, there have been additional reports of S. schenckii causing endophthalmitis (52,427) and uveitis (410). Vieira-Dias et al (410) reported the occurrence of concomitant ocular and cutaneous sporotrichosis, in which the fungus was isolated from skin lesions and the aqueous humor. Risk factors for endophthalmitis due to S. schenckii include AIDS (205) and trauma (427); however, this ocular infection may occur even in the absence trauma or systemic infection (52).…”

Section: Intraocular Mycoses (Excluding Endophthalmitis)mentioning

confidence: 99%

Current Perspectives on Ophthalmic Mycoses

2003

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Fungi may infect the cornea, orbit and other ocular structures. Species of Fusarium, Aspergillus, Candida, dematiaceous fungi, and Scedosporium predominate. Diagnosis is aided by recognition of typical clinical features and by direct microscopic detection of fungi in scrapes, biopsy specimens, and other samples. Culture confirms the diagnosis. Histopathological, immunohistochemical, or DNA-based tests may also be needed. Pathogenesis involves agent (invasiveness, toxigenicity) and host factors. Specific antifungal therapy is instituted as soon as the diagnosis is made. Amphotericin B by various routes is the mainstay of treatment for life-threatening and severe ophthalmic mycoses. Topical natamycin is usually the first choice for filamentous fungal keratitis, and topical amphotericin B is the first choice for yeast keratitis. Increasingly, the triazoles itraconazole and fluconazole are being evaluated as therapeutic options in ophthalmic mycoses. Medical therapy alone does not usually suffice for invasive fungal orbital infections, scleritis, and keratitis due to Fusarium spp., Lasiodiplodia theobromae, and Pythium insidiosum. Surgical debridement is essential in orbital infections, while various surgical procedures may be required for other infections not responding to medical therapy. Corticosteroids are contraindicated in most ophthalmic mycoses; therefore, other methods are being sought to control inflammatory tissue damage. Fungal infections following ophthalmic surgical procedures, in patients with AIDS, and due to use of various ocular biomaterials are unique subsets of ophthalmic mycoses. Future research needs to focus on the development of rapid, species-specific diagnostic aids, broad-spectrum fungicidal compounds that are active by various routes, and therapeutic modalities which curtail the harmful effects of fungus- and host tissue-derived factors

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“…Several conditions like alcoholism, diabetes, neoplasia, and acquired immunodeficiency syndrome are associated with disseminated cases and greater severity. [11][12][13] Most human immunodeficiency virus (HIV) -infected patients with disseminated sporotrichosis show protracted conditions, late diagnosis, and poor outcomes, despite antifungal treatment. Meningeal, ocular, respiratory, osteoarticular, and lymphatic involvement have been described as associated with fungemia.…”

Section: Introductionmentioning

confidence: 99%

Disseminated Sporothrix brasiliensis Infection with Endocardial and Ocular Involvement in an HIV-Infected Patient

Silva‐Vergara

Camargo²,

Silva³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Disseminated sporotrichosis occurs in individuals with impaired cellular immunity, such as in cases of neoplasia, transplantation, diabetes, and especially, acquired immunodeficiency syndrome. This report presents a 32-year-old Brazilian human immunodeficiency virus (HIV)-infected patient who developed a protracted condition of disseminated sporotrichosis with endocarditis, bilateral endophthalmitis, and lymphatic involvement. He needed cardiac surgery to replace the mitral valve. Sporothrix brasiliensis isolates were recovered from cultures of subcutaneous nodules and mitral valve fragments. Species identification was based on classical and molecular methods. The patient received amphotericin B for 52 days and subsequently, oral itraconazole. He remains asymptomatic, and he is on maintenance therapy with itraconazole. Despite his positive clinical outcome, he developed bilateral blindness. To our knowledge, this case is the first report of endocarditis and endophthalmitis caused by S. brasiliensis.

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Ocular and concomitant cutaneous sporotrichosis

Cited by 32 publications

References 12 publications

Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins

Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins

Current Perspectives on Ophthalmic Mycoses

Disseminated Sporothrix brasiliensis Infection with Endocardial and Ocular Involvement in an HIV-Infected Patient

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