Ocular and Systemic Complications of COVID-19: Impact on Patients and Healthcare

Leung, Ella H.; Fan, Jason; Flynn, Harry W.; Albini, Thomas A.

doi:10.2147/opth.s336963

Cited by 20 publications

(20 citation statements)

References 122 publications

(209 reference statements)

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“…The less-reported but sight-threatening ocular events included eye hemorrhages which were of retina origin (1.42%), ophthalmic herpes zoster/simplex (0.64%) and extra ocular muscle paresis (4.98%). Likewise, these events have been reported in COVID-19 patients too [23][24][25]. Surprisingly, cases of ocular contusion were also reported (0.85%) but, upon further investigation, we noticed that a significant proportion of these patients had symptoms of lightheadedness, headaches, dizziness, and numbness, which could have led to hitting their eyes against an obstacle.…”

Section: Discussionsupporting

confidence: 71%

Ocular Complications after COVID-19 Vaccination, Vaccine Adverse Event Reporting System

2022

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In December 2020, the U.S. Food and Drug Administration licensed COVID-19 vaccines for emergency use authorization. We investigated the ocular adverse event reports in patients reported to the Vaccine Adverse Event Reporting System (VAERS) following vaccination against COVID-19. We searched the VAERS database for U.S. reports among persons who received COVID-19 vaccines between December 2020 and December 2021. Our goal was to analyze and quantify the ocular adverse events submitted to VAERS to provide clinicians and researchers with a broader view of these ocular side effects. During the analysis period, VAERS received 55,313 adverse event reports and, after data cleaning, 6688 reports met the inclusion criteria. Note that 2229 (33.33%) adverse events were classified as cases of eyelid swelling, ocular hyperemia and conjunctivitis, 1785 (26.69%) as blurred vision and 1322 (19.77%) as visual impairment. Females accounted for 73.8% of adverse event reports and the age group between 40 and 59 years had the most frequent adverse events. A higher proportion of these adverse events reported to VAERS was linked with the Janssen and Moderna COVID-19 vaccines. At the time of vaccination, a high proportion of patients reported conditions like allergies, hypertension, diabetes, thyroid disease, vascular and other autoimmune diseases. A review of these data suggests a possible association between COVID-19 vaccines and ocular adverse events. Physicians are cautioned not only to be aware of this potential problem, but to check any underlying patient conditions, and to carefully document in VAERS within a few weeks of vaccination. Future COVID-19 vaccine safety studies in healthy subjects would help clarify the vaccine’s safety profile.

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Section: Discussionsupporting

confidence: 71%

Ocular Complications after COVID-19 Vaccination, Vaccine Adverse Event Reporting System

2022

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“…In this regard, DED may develop due to poor blink quality (mostly incomplete) or decreased blink rate (for example, due to enhanced exposure to blue light with short wavelengths) ( 98 ). Dry eye is associated not only with dietary consequences, but also with sleep deprivation and mental moods like anger and depression during COVID-19 pandemic ( 99 ). Quality of life can be reduced following quarantine dry eye, resulting in severe reduction in school and work efficiency.…”

Section: Resultsmentioning

confidence: 99%

Update on overview of ocular manifestations of COVID-19

Akbari

Dourandeesh²

2022

Front. Med.

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The coronavirus disease 2019 (COVID-19) has become the most critical health crisis at present, and research is continued about the exact pathophysiology, presentations, and complications of this pandemic. It influences several organs, and many studies have addressed the organs, the involvement of which during the COVID-19 results in patients' death. One of the important organs that can be involved during COVID-19, which is also a transmission route of the disease, is the eye. According to the evidence, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can have ocular manifestations and complications. According to the literature, conjunctivitis is the most common presentation, which can develop at any stage of COVID-19 (during and even after the disease), and the major pathophysiology of the eye involvement during the disease is attributed to the direct effect of the virus on the eyes, tissue damage caused by inflammation, underlying diseases, and the adverse effect of the medications prescribed. There are also reports of life-threatening complications, such as rhino-orbital cerebral mucormycosis, which require urgent treatment and are associated with a great mortality rate. Ocular manifestations may also be the presentation of a life-threatening event, such as stroke; therefore, it is necessary to pay great attention to the ocular manifestations during COVID-19. In this review, after about 2 years of the pandemic started, we present a narrative review on ocular manifestations during COVID-19, categorized into three main categories; ophthalmic, orbital, and neuro-ophthalmological manifestations with a detailed description of the presenting symptoms, risk factor, diagnostic, and therapeutic strategies suggested for each.

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“…COVID-19 ligos gydymui taikytas chlorokvinas ir hidroksichlorokvinas bei steroidai, siejami su įvairiais akių pakenkimais [4]. Akių pažeidimų padaugėjo ir dėl netiesioginių priežasčių − suprastėjusio sveikatos priežiūros paslaugų prieinamumo bei dažnesnių traumų namuose [5]. Su akių pažeidimu siejamas ir CO-VID-19 vakcinų šalutinis poveikis, tačiau dėl didelių vakcinacijos mastų labai sudėtinga nustatyti, ar vakcinų sukelti akių pažeidimai nebuvo tiesiog sutapimas, todėl į šį straipsnį neįtraukta informacija apie vakcinų sukeliamą šalutinį poveikį.…”

Section: Covid-19 Ligos Ir Jos Kontrolės Sukeliamas Akių Pakenkimasunclassified

“…Patirta ir socialinių problemų, tokių kaip socialinė distancija bei suprastėjęs sveikatos priežiūros paslaugų prieinamumas. Dėl pandemijos mažiau pacientų pasinaudojo sveikatos draudimu, vengta lankytis sveikatos priežiūros įstaigose dėl rekomenduotos socialinės izoliacijos, padaugėjo buitinių traumų [5]. Išvados 1.…”

Section: Tyrimo Rezultatai Ir Jų Aptarimasunclassified

Covid-19 Ligos Ir Jos Kontrolės Sukeliamas Akių Pakenkimas

Miliauskaitė

2022

Health Sciences

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Tyrimo tikslas – apžvelgti straipsnius, aprašančius SARS-CoV-2 viruso sukeltos COVID- 19 ligos bei jos gydymo ir prevencijos sąlygotus akių pažeidimus, apibendrinti tyrimų rezultatus bei pateikti visuomenei aktualią informaciją apie viruso sąsajas su akimis. Akies audiniuose esama specifinių viruso spyglio baltymui receptorių, per kuriuos virusas gali patekti į akies audinius, o iš jos ir į kitas organizmo dalis. Dažniausias COVID-19 ligos sukeliamas akių pakenkimas – konjunktyvitas. Kiti galimi pakenkimai – keratokonjunktyvitas, episkleritas, ragenos transplantato atmetimo reakcija, mukormikozė, neurooftalminės komplikacijos. COVID-19 akių pakenkimus sukelia ir dėl netiesioginių priežasčių – sumažėjusio sveikatos priežiūros paslaugų prieinamumo bei padažnėjusių akių traumų namuose.

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Ocular and Systemic Complications of COVID-19: Impact on Patients and Healthcare

Cited by 20 publications

References 122 publications

Ocular Complications after COVID-19 Vaccination, Vaccine Adverse Event Reporting System

Ocular Complications after COVID-19 Vaccination, Vaccine Adverse Event Reporting System

Update on overview of ocular manifestations of COVID-19

Covid-19 Ligos Ir Jos Kontrolės Sukeliamas Akių Pakenkimas

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