Ocular Bioanalysis of Moxifloxacin and Ketorolac Tromethamine in Rabbit Lacrimal Matrix Using Liquid Chromatography–Tandem Mass Spectrometry

Bisen, Amol Chhatrapati; Bhatta, Rabi Sankar

doi:10.4155/bio-2023-0233

Cited by 7 publications

(3 citation statements)

References 58 publications

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“…Ulcerative keratitis is the most common and distinctive type of corneal blindness. [94][95][96][97] It is a spontaneous and long-lasting result of a microbial infection of the cornea, which is usually marked by ocular surface dystrophy. [98,99] Following post-operative surgery, trauma, and various ophthalmic procedures, the occurrence of bacterial and fungal co-infections can lead to the development of ulcers on the cornea.…”

Section: Ulcerative Microbial Keratitismentioning

confidence: 99%

Pirfenidone: A Promising Drug in Ocular Therapeutics

Bisen,

Agrawal,

Rayiti

et al. 2024

Chemistry & Biodiversity

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Pirfenidone, initially indicated for lung fibrosis, has gone beyond its original purpose, and shown promise in eye care. This detailed review tracks its evolution from lung treatment to aiding eye healing as evidenced by published literature. Pirfenidone's multifaceted attributes extend to mitigating corneal fibrosis, inflammation, and trauma. Through rigorous investigations, its efficacy emerges in diabetic retinopathy, macular degeneration, and postoperative glaucoma interventions. As an unheralded protagonist, pirfenidone reshapes ocular care paradigms, inviting renewed research opportunities.

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Section: Ulcerative Microbial Keratitismentioning

confidence: 99%

Pirfenidone: A Promising Drug in Ocular Therapeutics

Bisen,

Agrawal,

Rayiti

et al. 2024

Chemistry & Biodiversity

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“…These agents can be used standalone or in conjunction with anti-infective agents such as antifungal medication to reduce the pain incurred. For example: ketorolac tromethamine, diclofenac sodium, nepafenac, bromfenac etc. , Immunomodulators such as cyclosporin and lifitegrast are typically indicated following postoperative surgeries . However, their prolonged use may increase the risk of fungal comorbidities, which can potentially be life-threatening.…”

Section: Treatment and Therapeutic Intervention For Fkmentioning

confidence: 99%

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Bisen,

Sanap,

Agrawal

et al. 2024

ACS Infect. Dis.

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Fungal keratitis (FK) is a severe ocular condition resulting from corneal infection that is prevalent in tropical countries, particularly in developing regions of Asia and Africa. Factors like corneal lens misuse, inappropriate steroid use, and diagnostic challenges have provoked the epidemic. FK causes significant vision impairment, scarring, and ocular deformities. Accurate pathological diagnosis is crucial for effective therapeutic intervention. Topical antifungal therapy with surface healing medications proves effective in preventing fungal-borne ulcers. Managing FK requires a comprehensive understanding of fungal pathogenesis, guiding formulation strategies and preventive measures to curb global ocular blindness. This review provides in-depth insights into FK, covering etiology, epidemiology, pathogenesis, therapeutic interventions, antifungal resistance, limitations, prevention, and future perspectives on ocular surface disease management.

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“…Argon was used as the collision gas for stable Q3 formation. The operation, quantification, and analysis were done using LabSolutions software Version 5.99 SP2 (Shimadzu Corporation, Kyoto, Japan) …”

Section: Lc–ms/ms Conditionsmentioning

confidence: 99%

Design, Synthesis, and Biological Evaluation of 1,4-Dihydropyridine–Indole as a Potential Antidiabetic Agent via GLUT4 Translocation Stimulation

Katiyar,

Ahmad,

Kumar

et al. 2024

J. Med. Chem.

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In the quest for the discovery of antidiabetic compounds, a series of 27 1,4-dihydropyridine−indole derivatives were synthesized using a diversity approach. These compounds were systematically evaluated for their antidiabetic activity, starting with an in vitro assessment for GLUT4 translocation stimulation in L6-GLUT4myc myotubes, followed by in vivo antihyperglycemic activity evaluation in a streptozotocin (STZ)-induced diabetic rat model. Among the synthesized compounds, 12,14,15,16,19,27, and 35 demonstrated significant potential to stimulate GLUT4 translocation in skeletal muscle cells. Compound 19 exhibited the highest potency and was selected for in vivo evaluation. A notable reduction of 21.6% (p < 0.01) in blood glucose levels was observed after 5 h of treatment with compound 19 in STZ-induced diabetic rats. Furthermore, pharmacokinetic studies affirmed that compound 19 was favorable to oral exposure with suitable pharmacological parameters. Overall, compound 19 emerged as a promising lead compound for further structural modification and optimization.

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Ocular Bioanalysis of Moxifloxacin and Ketorolac Tromethamine in Rabbit Lacrimal Matrix Using Liquid Chromatography–Tandem Mass Spectrometry

Cited by 7 publications

References 58 publications

Pirfenidone: A Promising Drug in Ocular Therapeutics

Pirfenidone: A Promising Drug in Ocular Therapeutics

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Design, Synthesis, and Biological Evaluation of 1,4-Dihydropyridine–Indole as a Potential Antidiabetic Agent via GLUT4 Translocation Stimulation

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