Ocular biodistribution of cysteamine delivered by a sustained release microsphere/thermoresponsive gel eyedrop

Jimenez, Jorge; Resnick, Jayde L; Chaudhry, Ahmad B; Gertsman, Ilya; Nischal, Ken K.; DiLeo, Morgan V.

doi:10.1016/j.ijpharm.2022.121992

International Journal of Pharmaceutics

2022

DOI: 10.1016/j.ijpharm.2022.121992

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Ocular biodistribution of cysteamine delivered by a sustained release microsphere/thermoresponsive gel eyedrop

Jorge Jimenez

Jayde L Resnick

Ahmad B Chaudhry

et al.

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Cited by 4 publications

References 35 publications

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Mass spectrometry in ocular drug research

del Amo,

Vellonen,

Urtti

et al. 2023

Mass Spectrometry Reviews

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Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments. The second part of the review consists of an introduction to ocular proteomics, with special emphasis on targeted absolute quantitation of membrane transporters and metabolizing enzymes. The third part of the review deals with liquid chromatography–MS (LC‐MS) and MS imaging (MSI) methods used in the analysis of drugs and metabolites in ocular samples. The sensitivity and speed of LC‐MS make simultaneous quantitation of various drugs and metabolites possible in minute tissue samples, even though ocular sample preparation requires careful handling. The MSI methodology is on the verge of becoming as important as LC‐MS in ocular pharmacokinetic studies, since the spatial resolution has reached the level, where cell layers can be separated, and quantitation with isotope‐labeled standards has come more reliable. MS will remain in the foreseeable future as the main analytical method that will progress our understanding of ocular pharmacokinetics.

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Mass spectrometry in ocular drug research

del Amo,

Vellonen,

Urtti

et al. 2023

Mass Spectrometry Reviews

View full text Add to dashboard Cite

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Cyclic RGD conjugated PEG-PLGA nanoparticle enhances preventative effect of bilirubin on the development of ultraviolet-B (UVB)-induced cataract

Jin,

Huang,

Jin

et al. 2024

Chemical Engineering Journal

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Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration

Campbell,

Amin,

Hsieh

et al. 2024

npj Regen Med

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Modulating inflammation is critical to enhance nerve regeneration after injury. However, clinically applicable regenerative therapies that modulate inflammation have not yet been established. Here, we demonstrate synergistic effects of the combination of an HMG-CoA reductase inhibitor, statin/fluvastatin and critical components of the extracellular matrix, Matrix-Bound Nanovesicles (MBV) to enhance axon regeneration and neuroprotection after mouse optic nerve injury. Mechanistically, co-intravitreal injections of fluvastatin and MBV robustly promote infiltration of monocytes and neutrophils, which lead to RGC protection and axon regeneration. Furthermore, monocyte infiltration is triggered by elevated expression of CCL2, a chemokine, in the superficial layer of the retina after treatment with a combination of fluvastatin and MBV or IL-33, a cytokine contained within MBV. Finally, this therapy can be further combined with AAV-based gene therapy blocking anti-regenerative pathways in RGCs to extend regenerated axons. These data highlight novel molecular insights into the development of immunomodulatory regenerative therapy.

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Ocular biodistribution of cysteamine delivered by a sustained release microsphere/thermoresponsive gel eyedrop

Cited by 4 publications

References 35 publications

Mass spectrometry in ocular drug research

Mass spectrometry in ocular drug research

Cyclic RGD conjugated PEG-PLGA nanoparticle enhances preventative effect of bilirubin on the development of ultraviolet-B (UVB)-induced cataract

Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration

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