Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis

Abstract

Ametropia is reported as a common ophthalmic manifestation in craniosynostosis. We retrospectively compared childhood refractive error and ocular biometric features of fibroblast growth factor receptor (FGFR)-related syndromic craniosynostosis patients with those of non-syndromic craniosynostosis and control subjects. Thirty-six eyes (18 patients) with FGFR-related syndromic craniosynostosis, 76 eyes (38 patients) with non-syndromic craniosynostosis, and 114 eyes (57 patients) of intermittent exotropes were included in the analysis. Mean age at examination was 7.82 ± 2.51 (range, 4–16) years and mean spherical equivalent was -0.09 ± 1.46 Diopter. Mean age and refractive error were not different between groups, but syndromic craniosynostosis patients had significantly longer axial length, lower corneal power, and lower lens power than other groups (p < 0.01, p < 0.01, and p < 0.01, respectively). Axial length was positively correlated and keratometry and lens power were negatively correlated with age in non-syndromic craniosynostosis and controls, while these correlations between age and ocular biometric parameters were not present in the FGFR-related syndromic craniosynostosis. In conclusion, ocular biometric parameters in FGFR-related syndromic craniosynostosis differed from those of non-syndromic craniosynostosis and age-matched controls, and did not show the relations with age, suggesting this cohort may have abnormal refractive growth.

Sunset Yellow protects against oxidative damage and exhibits chemoprevention in chemically induced skin cancer model

“…Aberrant FGFRs signaling has been implicated in various cancer types, which motivated the development of selective FGFR2 inhibitors 25 , 26 . Our results indicate that SY has a much higher binding affinity with two experimentally validated FGFR2 inhibitors, ACP 27 and M33 28 .

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Characterization of eggshell as a bio-regeneration material

“…The fibroblast growth factor (FGF) family of cytokines mediate processes including cellular proliferation, migration, and differentiation; mitogenesis; angiogenesis; embryonic development; and wound healing [ 69 ]. Mutations in FGFs or FGFRs are involved in the development of various skeletal dysplasias, including achondroplasia and craniosynostosis [ 70 , 71 ]. FGF, a subtype of growth factor, has been connected to several osteoinductive pathways.…”