Ocular Changes in Dystrophia myotonica

Junge, Jasmine

doi:10.1159/000305294

Cited by 9 publications

(5 citation statements)

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“…This finding is in agreement with several other studies that reported low IOP using GAT (2)(3)(4)(5)(6)12,13) . One study, conducted by Rosa et al (13) , also found lower IOP in dystrophy patients using ORA.…”

Section: Discussionsupporting

confidence: 93%

“…Low intraocular pressure (IOP) is a common finding in myotonic dystrophy patients, but its pathophysiologic mechanism remains unclear. Jung (5) suggested that the hypotony was secondary to a high uveal-scleral outflow. Other authors (6,7) suggested an association of the high uveal-scleral outflow with a reduced production of aqueous humor secondary to ciliary body atrophy.…”

Section: Introductionmentioning

confidence: 99%

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Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy

Filho

Prata

Sousa

et al. 2011

Arq. Bras. Oftalmol.

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Purpose: Low intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) is one of the ocular manifestations of Steinert's myotonic dystrophy. The goal of this study was to evaluate the corneal-compensated IOP as well as corneal properties (central corneal thickness and corneal hysteresis) in patients with myotonic dystrophy. Methods: A total of 12 eyes of 6 patients with Steinert's myotonic dystrophy (dystrophy group) and 12 eyes of 6 age-, race-, and gender-matched healthy volunteers (control group) were included in the study. GAT, Dynamic Contour Tonometry (DCT-Pascal) and Ocular Response Analyzer (ORA) were used to assess the IOP. Central corneal thickness was obtained by ultrasound pachymetry, and corneal hysteresis was analyzed using the ORA device. In light of the multiplicity of tests performed, the significance level was set at 0.01 rather than 0.05. Results:The mean (standard deviation [SD]) GAT, DCT, and corneal-compensated ORA IOP in the dystrophy group were 5.4 (1.4) mmHg, 9.7 (1.5) mmHg, and 10.1 (2.6) mmHg, respectively. The mean (SD) GAT, DCT, and corneal-compensated ORA IOP in the control group was 12.6 (2.9) mmHg, 15.5 (2.7) mmHg, and 15.8 (3.4) mmHg, respectively. There were significant differences in IOP values between dystrophy and control groups obtained by GAT (mean, -7.2 mmHg; 99% confidence interval [CI], -10.5 to -3.9 mmHg; P<0.001), DCT (mean, -5.9 mmHg; 99% CI, -8.9 to -2.8 mmHg; P<0.001), and corneal-compensated ORA measurements (mean, -5.7 mmHg; 99% CI, -10.4 to -1.0 mmHg; P=0.003). The mean (SD) central corneal thickness was similar in the dystrophy (542 [31] μm) and control (537 [11] μm) groups (P=0.65). The mean (SD) corneal hysteresis in the dystrophy and control groups were 11.2 (1.5) mmHg and 9.7 (1.2) mmHg, respectively (P=0.04). Conclusions: Patients with Steinert's myotonic dystrophy showed lower Goldmann and corneal-compensated IOP in comparison with healthy individuals. Since central corneal thickness and corneal hysteresis did not differ significantly between groups, the lower IOP readings documented in this dystrophy seem not to be related to changes in corneal properties. 12,6 (2,9) mmHg, 15,5 (2,7) mmHg e 15,8 (3,4) mmHg, respectivamente. Houve diferença significativa nos valores da pressão intraocular entre os grupos distrofia e controle obtidas pela TAG (média,2 mmHg; intervalo de confiança (IC) de 99%,9 mmHg; P<0,001), TCD (média,9 mmHg; IC de 99%,8 mmHg; P<0,001) e ORA compensada para córnea (média,7 mmHg; IC de 99%,0 mmHg; P=0,003 Keywords

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy

Filho

Prata

Sousa

et al. 2011

Arq. Bras. Oftalmol.

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“…Ocular hypotony is common in patients with myotonic dystrophy ( 1,2,3,7,9). Potential mechanisms for ocular hypotony are many.…”

Section: Introduction Methodsmentioning

confidence: 99%

“…Several investigators have reported increased outflow coefficients, but state their tonographic results are hard to interpret (4,5,7). Several investigators have reported increased outflow coefficients, but state their tonographic results are hard to interpret (4,5,7).…”

Section: Introduction Methodsmentioning

confidence: 99%

Ocular hypotony in myotonic dystrophy

1983

Int Ophthalmol

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Ocular hypotony is a common, unexplained feature of myotonic dystrophy. Some investigators have ascribed the decrease in intraocular pressure to unusually high outflow facility. The present study demonstrates that increased outflow facility in myotonics is often artifactitious. When corrected for ocular rigidity, outflow facility is frequently normal. The present study presents indirect evidence that ocular hypotony in myotonics results from reduced aqueous production or increased uveoscleral outflow.

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“…1 In a study of more than 300 individuals from 9 MD families all affected members above 20 years of age had cataracts. 2 In the initial stages MD cataract is characterized by white, light-scattering opacities in the outermost regions of the lens. The later stages show evidence of cortical swelling along the suture lines, and this finally progresses to a mature cataract in which, in slit lamp examination, "an iridescent display of scintillating colors" (Ref.…”

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confidence: 99%