Ocular Cicatricial Pemphigoid With Granular IgA and Complement Deposition

Proia, Alan D.; Foulks, Gary N.; Sanfilippo, Fred

doi:10.1001/archopht.1985.01050110063026

Cited by 11 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is noteworthy that the need of ocular cells for protection has not been widely appreciated previously as there are limited data regarding the complement system in ocular disease. With the exception of ocular cicatricial pemphigoid 33–35 and bacterial keratitis, 36 only scattered reports 37–39 of the role of complement in their pathology are available.…”

Section: Discussionmentioning

confidence: 99%

Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis

et al. 2001

View full text Add to dashboard Cite

SUMMARYThe open environment of the eye is continuously subject to an in¯ux of foreign agents that can activate complement. Decay-accelerating factor (DAF), membrane cofactor protein (MCP) and CD59 are regulators that protect self-cells from autologous complement activation on their surfaces. They are expressed in the eye at unusually high levels but their physiological importance in this site is unstudied. In the rat, a structural analogue termed 5I2 antigen (5I2 Ag) has actions overlapping DAF and MCP. In this investigation, we injected F(abk ) 2 fragments of 5I2 mAb into the conjunctiva and aqueous humor, in the latter case with and without concomitant blockage of CD59. Massive neutrophilic in®ltration of the stroma and iris resulted upon blocking 5I2 Ag activity. Frank necrosis of the iris occurred upon concomitant intraocular blockage of CD59. C3b was identi®ed immunohistochemically, and minimal effects were seen in complement-depleted animals and in those treated with non-relevant antibody. The ®nding that blockage of 5I2 Ag function in periocular tissues and within the eye causes intense conjunctival in¯ammation and iritis demonstrates the importance of intrinsic complement regulators in protecting ocular tissues from spontaneous or bystander attack by autologous complement.

show abstract

Section: Discussionmentioning

confidence: 99%