Ocular deposition of copper associated with multiple myeloma

Hawkins, Anjali S; Stein, Robert; Gaines, Bruce I; Deutsch, Thomas A.

doi:10.1016/s0002-9394(00)00657-7

Cited by 36 publications

(19 citation statements)

References 3 publications

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“…Other ocular findings including crystal [6, 7, 10, 11]or copper deposits [5, 9]in the cornea and ciliary body cysts [4, 8, 12, 13, 30]were not observed in this series. These are frequently asymptomatic.…”

Section: Discussionmentioning

confidence: 63%

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Ophthalmic Manifestations of Multiple Myeloma

et al. 2005

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Purpose: To describe ophthalmic manifestations in a series of patients with multiple myeloma (MM) and review the literature. Design: Retrospective case series. Methods: Review of all cases with ophthalmic manifestations of MM seen at the Department of Ophthalmology, Royal Adelaide Hospital, between 1987 and 2002. Results: Of all patients with MM who were managed at the Royal Adelaide Hospital in the study period, only 8 were referred to the Ophthalmology Department with ophthalmic manifestations. Five males and 3 females with a mean age of 61.25 years (range 42–78) who exhibited ophthalmic manifestations were studied. Six patients (75%) had known MM at the time of their ophthalmic evaluation. Four patients (50%) had neuro-ophthalmic symptoms resulting in diplopia or visual disturbances. Three patients (37.5%) presented with orbital involvement and 1 (12.5%) with hyperviscosity retinopathy. Five patients (62.5%) died within 2 months of their ophthalmic presentation. Conclusion: Ophthalmic manifestations of MM are uncommon and diverse. They may appear at the initial presentation of the disease or occur late in the disease process. Awareness of the possible manifestations may lead to an earlier diagnosis and have a positive influence on the disease course.

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Section: Discussionmentioning

confidence: 63%

“…Common ocular findings include crystal or copper deposition in the cornea, ciliary body cysts and retinopathy of hyperviscosity [5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. These findings tend to be asymptomatic and in some cases, such as ciliary body cysts, may only be found at autopsy [3].…”

Section: Introductionmentioning

confidence: 99%

Ophthalmic Manifestations of Multiple Myeloma

et al. 2005

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“…Ocular chalcosis is seen in the setting of an intraocular foreign copper body and copper is deposited in the Descemet membrane and lens capsule 5. Copper deposition within the cornea occurs also rarely in cases of systemic malignancy 6. Ocular argyrosis refers to silver deposits in the cornea and has been observed with the use of topical solutions containing silver proteins (a popular treatment for various ocular disorders) and occupational contact with silver 7.…”

Section: Answersmentioning

confidence: 99%

Peripheral corneal ring due to hypercarotenaemia in a case of nutritional supplement abuse

2011

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“…The differential WBC count included 56% neutrophils, 38.1% lymphocytes, and 5.9% monocytes. Platelet level was 198,000/mm 3 Because of the risk of developing a disease such as myeloma or amyloidosis requiring therapy, the patient is being monitored with serum protein electrophoresis to observe changes in the serum M-protein level at annual intervals indefinitely for evidence of progression of the MGUS.…”

Section: Relatos De Casosmentioning

confidence: 99%

“…Bilateral deposition of copper on Descemet's membrane occurs in a variety of conditions associated with hypercupremia, including multiple myeloma (1)(2)(3) , pulmonary carcinoma (4) , and also benign monoclonal gammanopathies (5)(6) . We describe the third case in the literature of deposition of copper in Descemet's membrane, which was found to be secondary to monoclonal gammopathy of undetermined significance (MGUS).…”

Section: Introductionmentioning

confidence: 99%