Ocular diseases and 10‐year mortality: The <scp>B</scp>eijing <scp>E</scp>ye <scp>S</scp>tudy 2001/2011

Wang, Ya Xing; Zhang, Jing Shang; You, Qi Sheng; Xu, Liang; Jonas, Jost B.

doi:10.1111/aos.12370

Cited by 37 publications

(47 citation statements)

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“…[3][4][5][6][7][8][9][10] It has been speculated that oxidation with aging and oxidative stresses on the lens 17 could explain some of the complex etiology of cataract. In addition, cataract is regarded as the translational ''window to the rest of the body,'' suggesting cataract perhaps is a biomarker for aging at the molecular, epigenetic, cellular, and clinical levels.…”

Section: Discussionmentioning

confidence: 99%

“…2 There is consistent evidence showing that persons with cataract have a higher risk of mortality compared with persons without cataract. [3][4][5][6][7][8][9][10] Cataract surgery is the only effective treatment for people with cataract, and is the most commonly performed clinical procedure in the medical field. 11 In addition to improving visual function, some evidences suggest that cataract surgery is associated with better chances of survival, although this has yet to be conclusive.…”

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confidence: 99%

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Cataract-Related Visual Impairment Corrected by Cataract Surgery and 10-Year Mortality: The Liwan Eye Study

Zhu

Wang

Young

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To assess 10-year mortality in people who had undergone cataract surgery with no residual visual impairment (VI) and those who had persistent VI due to cataract using a population-based cohort.METHODS. The Liwan Eye Study is a 10-year longitudinal study commenced in 2003. According to the World Health Organization, presenting VI was defined as visual acuity less than 20/63 in the better-seeing eye. History of cataract surgery was defined as cataract surgery performed on either eye. Information on the date of surgery was recorded. Dates of death occurring between baseline and April 30, 2014 were obtained from the National Death Index data. Information on socioeconomic factors was obtained from questionnaire interviews. Cox proportional hazards regression models were used to assess the hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS. Fifty-nine participants had undergone cataract surgery without residual VI and 67 participants had persistent cataract-related VI. The 10-year mortality rate for participants who had undergone cataract surgery without residual VI was statistically significant lower than that in participants who had VI due to cataract based on log-rank test (32.2% vs. 64.2%; P ¼ 0.002). This finding remained significant in the unadjusted Cox proportional hazards model (HR, 0.43; 95% CI, 0.25-0.74; P ¼ 0.002). After adjusting for age, sex, history of diabetes, and hypertension, body mass index (BMI), education level, and personal income, participants with cataract surgery and no residual VI did not have a higher chance of survival than participants with persistent VI due to cataract (HR, 0.56; 95% CI, 0.26-1.20; P ¼ 0.136).CONCLUSIONS. Cataract-related VI corrected by cataract surgery was not associated with better survival after adjusting for a number of possible confounders. Given our sample size is relatively small and limited power, further studies with larger sample are needed.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Cataract-Related Visual Impairment Corrected by Cataract Surgery and 10-Year Mortality: The Liwan Eye Study

Zhu

Wang

Young

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…9,17,[30][31][32] Other recent studies by the Beijing Eye Study, such as the observed association between the estimated cerebrospinal fluid pressure and retinal vein diameter in arterial hypertension, and the 10-year mortality of ocular diseases, do not have a direct association with the topic of the current study. 33,34 From a practical point of view, one may raise the question whether brain imaging should be performed to exclude cerebral ischemic attacks in patients without glaucoma or diabetic retinopathy and who present with an incident RNFLD. The design of our study did not allow answering such a question.…”

Section: Discussionmentioning

confidence: 99%

Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011

Ren

Wang

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We examined the 10-year incidence of localized retinal nerve fiber layer defects (RNFLDs) and associated factors in adult Chinese.METHODS. The population-based longitudinal Beijing Eye Study, which included 4439 subjects (age, 40þ years) in 2001, was repeated in 2011 with 2695 subjects participating (66.4% of the survivors). Color fundus photographs taken at baseline and 10 years later were examined for localized RNFLDs, defined as wedge-shaped defects running toward the optic disc.RESULTS. Fundus photographs were available for 2422 (89.9%) subjects. Incident-localized RNFLDs were detected in 114/2422 persons (4.7% 6 0.2%) or 139/4867 eyes (2.9% 6 0.2%). A total of 25 (22%) persons had incident-localized RNFLDs bilaterally, and 89 (78%) persons unilaterally. Among the 114 persons with incident RNFLDs, 78 persons showed newly developed localized RNFLDs, while 36 subjects showed an enlargement of a preexisting localized RNFLD. In binary logistic regression analysis, a higher 10-year incidence of localized RNFLDs was significantly associated with a higher prevalence of arterial hypertension (P ¼ 0.002; odds ratio [OR], 2.31; 95% confidence interval (CI), 1.35, 3.97), higher diastolic blood pressure (P ¼ 0.02; OR, 1.02; 95% CI, 1.004,1.04), higher prevalence of previous cerebrovascular infarctions (P ¼ 0.007; OR, 2.61; 95% CI, 1.30, 5.22), younger age (P ¼ 0.01; OR, 0.97; 95% CI, 0.94, 0.99), higher prevalence of diabetic retinopathy (P ¼ 0.001; OR, 4.70; 95% CI, 1.92, 11.5), higher prevalence of open-angle (P < 0.001; OR, 39.8; 95% CI, 19.7, 80.5) and angle-closure (P < 0.001; OR, 21.3; 95% CI, 7.90, 57.5) glaucoma, and thinner retinal nerve fiber layer (P < 0.001; OR, 0.97; 95% CI, 0.95, 0.98).CONCLUSIONS. The 10-year incidence of localized RNFLDs in adult Chinese is 4.7% 6 0.2%. It is strongly associated with arterial hypertension and higher prevalence of cerebrovascular infarcts, in addition to ocular reasons, such as glaucoma and diabetic retinopathy. Ophthalmologically normal subjects with incident-localized RNFLDs may be screened for arterial hypertension and cerebrovascular infarcts.Keywords: retinal nerve fiber layer, stroke, glaucoma, optic nerve, optic disc, Beijing Eye Study T he optic nerve as cerebral fascicle has its origin in the retinal ganglion cell layer. Its axons extend from the inner retina through the optic disc, optic nerve, and optic tract to the lateral geniculate ganglion. Any optic nerve damage affects the retinal nerve fiber layer (RNFL) through the loss of optic nerve fibers. The RNFL has conventionally been examined by ophthalmoscopy or on color fundus photographs. [1][2][3][4][5] The visibility of the RNFL shows a specific pattern with usually the best visibility in the temporal inferior arcade, followed by the temporal superior arcade, nasal superior arcade, and nasal inferior arcade. 6 The distribution of the RNFL visibility correlates with the thickness of the RNFL as measured by histomorphometry or confocal scanning laser tomography, with the diameter of the retinal arter...

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“…Recent studies have linked cigarette smoking to an increased risk of developing cataracts in men and women [19]. Several studies have indicated that GST enzymes may play a role in cataract predisposition with different GST phenotypes [16,[20][21][22][23] but no associations were found in another study [24].…”

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confidence: 99%

Glutathione S-Transferase GSTM 1, Null Genotype May Be Associated With Susceptibility to Age-Related Cataract

Çelik¹,

Yıldırım²,

Turan³

et al. 2015

Adv Clin Exp Med

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Background. Age-related cataract (ARC) is the leading cause of visual disability and reversible blindness all over the world. The different expressions of GST isozymes among animals may explain the variations in the cataract formation caused by oxidative stress. Objectives. In this study, we evaluated the distribution of GST gene polymorphisms in ARC patients and the possible associations between the presence of ARC and GST gene polymorphisms. Material and Methods. The epidemiological data was collected by a standard questionnaire and blood samples were obtained from 130 ARC patients and 159 healthy controls. Data about smoking habits of the groups was recorded. Real-time polymerase chain reaction-based methods were used to detect genetic polymorphisms. Results. The GSTM 1 null genotype was found to carry an increased risk for developing ARC (OR: 1.84, 95% CI: 1.13-2.99). The frequency of the GSTT 1 null genotype was not significantly different among the ARC patients and the controls (OR: 1.0, 95% CI: 0.64-1.6). The GSTP 1 Val/Val genotype was also not significantly different among the ARC patients and control groups (OR: 1.06, 95% CI: 0.50-2.23). GSTM 1 null genotype was highly frequent in non-smokers (OR: 3.25, 95% CI: 1.66-6.35) and moderately frequent in smokers (OR: 2.50, 95% CI: 1.28-4.86). Also, carrying the combined genotypes of GSTM 1 null, GSTT 1 and GSTP 1 105-Val allele was seen to have an increased risk of developing ARC (OR: 2.91, 95% CI: 1.31-6.44). Conclusions. This data may provide evidence that GSTM 1 gene polymorphisms may be associated with genetic susceptibility to develop ARC. Larger studies are warranted to verify these findings (Adv Clin Exp Med 2015, 24, 1, 113-119).

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Ocular diseases and 10‐year mortality: The Beijing Eye Study 2001/2011

Cited by 37 publications

References 28 publications

Cataract-Related Visual Impairment Corrected by Cataract Surgery and 10-Year Mortality: The Liwan Eye Study

Cataract-Related Visual Impairment Corrected by Cataract Surgery and 10-Year Mortality: The Liwan Eye Study

Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011

Glutathione S-Transferase GSTM 1, Null Genotype May Be Associated With Susceptibility to Age-Related Cataract

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