Ocular Features in Neurosarcoidosis

Menezo, Víctor; Lobo, Aires; Yeo, Tun Kuan; Bois, Roland M. du; Lightman, Susan

doi:10.1080/09273940802687812

Cited by 23 publications

(16 citation statements)

References 48 publications

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“…In patients with sarcoidosis in general, anterior uveitis is the most common cause of change in vision [26]. Optic neuropathy in HP NS may be due to mass effect or direct involvement of the optic chiasm.…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic–pituitary sarcoidosis with vision loss and hypopituitarism: case series and literature review

2015

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Section: Discussionmentioning

confidence: 99%

Hypothalamic–pituitary sarcoidosis with vision loss and hypopituitarism: case series and literature review

2015

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“…Hearing loss and vestibular dysfunction manifesting with dizziness are usually due to VIII nerve impairment (6). Descriptions of trigeminal nerve (V) dysfunction, presenting, most often, with facial paresthesias and hyperesthesia and, rarely, with typical neuralgia, and of the nerves involved in eye movements (III, IV, and VI) have also been reported in the literature (41)(42)(43). Other clinical findings of BNS are seizures or focal neurological deficits such as hemiparesis, often associated with brain tumor-like lesions exerting mass effect (37,38,44,45), and dysfunction of the endocrine system, which most commonly presents with diabetes insipidus, gonadotropin and TSH deficiency, and hyperprolactinemia (46).…”

Section: Central Nervous System (Cns) Sarcoidosismentioning

confidence: 99%

Challenges in the diagnosis and treatment of neurosarcoidosis

et al. 2015

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The diagnosis and treatment of neurosarcoidosis can be very challenging for several reasons. It affects clinically 5%-10% of sarcoidosis patients, but can be found in up to 25% of autopsies. These data reveal that a high percentage of asymptomatic or misdiagnosed cases can be missed at an initial diagnostic approach. Clinical and imaging findings are often non-specific since they can be found in a large number of neurological disorders. Histopathology can also be confounding if not performed by an expert pathologist and not placed in an appropriate clinical context. In this review, we discuss clinical features, laboratory findings, imaging, and histology of neurosarcoidosis, and we report current evidence regarding drug therapy. We conclude that a correct diagnostic approach should include a multidisciplinary evaluation involving clinicians, radiologists, and pathologists and that future studies should evaluate the genetic signature of neurosarcoidosis as they could be helpful in the assessment of this uncommon disease. With head-to-head comparisons of medical treatment for neurosarcoidosis still lacking due to the rarity of the disease and an increasing number of immunomodulating therapies at hand, novel therapeutic approaches are to be expected within the next few years. Key messages Neurosarcoidosis is a rare disorder that affects clinically 5%-10% of sarcoidosis patients, but can be found in up to 25% of autopsies, revealing that a high percentage of asymptomatic or misdiagnosed cases can be missed at an initial diagnostic approach. A multidisciplinary evaluation is useful to achieve a correct diagnosis because clinical and imaging findings are often non-specific. Corticosteroids are the first-line treatment for neurosarcoidosis, followed by steroid-sparing immune-modulating agents if prednisone therapy is insufficient. Dear Author, Please check these proofs carefully. It is the responsibility of the corresponding author to check against the original manuscript and approve or amend these proofs. A second proof is not normally provided. Informa Healthcare cannot be held responsible for uncorrected errors, even if introduced during the composition process. The journal reserves the right to charge for excessive author alterations, or for changes requested after the proofing stage has concluded.The following queries have arisen during the editing of your manuscript and are marked in the margins of the proofs. Unless advised otherwise, submit all corrections using the CATS online correction form. Once you have added all your corrections, please ensure you press the ''Submit All Corrections'' button.Please review the table of contributors below and confirm that the first and last names are structured correctly and that the authors are listed in the correct order of contribution. The diagnosis and treatment of neurosarcoidosis can be very challenging for several reasons. It affects clinically 5%-10% of sarcoidosis patients, but can be found in up to 25% of autopsies. These data reveal that a high percenta...

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“…Because ocular sarcoidosis and neurosarcoidosis often occur concomitantly [75,76], an ophthalmologic evaluation is often useful to suggest the diagnosis of neurosarcoidosis. A slit lamp and fundoscopic examination should be performed as sarcoidosis may affect any portion of the eye [26].…”

Section: Other Studiesmentioning

confidence: 99%