Ocular findings in Japanese children with Down syndrome: the course of visual acuity and refraction, and systemic and ocular anomalies

Terai, Tomoko; Eda, Shohei; Sugasawa, Jun; Tonari, Masahiro; Matsuo, Junko; Oku, Hidehiro; Ikeda, Tsunehiko

doi:10.2147/opth.s169107

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…This value was found, considering only studies that reported the percentage of ocular manifestations in the DS group. These studies were conducted by Afifi et al [18], Akinci et al [19], Fimiani et al [20], Kim et al [21], Roizen et al [22], Terai et al [23], and Wong et al [24].…”

Section: Synthesis Of Resultsmentioning

confidence: 99%

Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature

et al. 2022

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Background Down syndrome (DS) is a chromosomal anomaly that is characterized by an extra chromosome 21. Ophthalmological manifestations have a high prevalence in patients with DS. Purpose To review the scientific evidence and estimate the prevalence of ophthalmological manifestations in the pediatric population with DS. Data sources Electronic databases including MEDLINE, Cochrane Library, EMBASE, ScienceDirect, and LILACS. Study eligibility criteria Published observational studies with available and original data were included. Articles were excluded if the study design was a review, letter to the editor, case report, case series, or systematic review and if the subjects had ophthalmological manifestations secondary to other conditions. Participants and interventions Pediatric and adolescent population with DS and with ophthalmological evaluation. Study appraisal and synthesis methods A data collection form was designed in Excel. Five reviewers extracted relevant details about the design and results of each study. The quality of the studies was assessed by applying the tools for systematic reviews of prevalence and incidence from the Joanna Briggs Institute. We calculated the weighted prevalence of ophthalmological manifestations, considering only the studies reporting the measurement of each manifestation. Results Twenty-two articles (from 15 countries, published during 1994–2020) were included in the present systematic review. Ocular manifestations were observed in 85% of the studied pediatric and adolescent populations with DS. The most frequent ones were slanting fissures, oblique fissures, epicanthus, and epiblepharon. Conclusion The ocular manifestations in the pediatric and adolescent populations with DS are varied, and some can irreversibly affect visual development. Screening of the pediatric population with DS should be conducted from the first months of age and continued annually. Systematic review registration PROSPERO CRD42019127717

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Section: Synthesis Of Resultsmentioning

confidence: 99%

Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature

et al. 2022

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“…In line with previous research, DS was a signi cant risk factor for various ocular disorders, including strabismus, nystagmus, high astigmatism, and cataract. 24,25 However, we found that DS was the only protective factor for ocular hypertension. Thinner corneal thickness in DS individuals, as reported by Haugen et al 26 , may contribute to lower intraocular pressure.…”

Section: Discussionmentioning

confidence: 63%

Risk Factors of Ocular Disorders among Institutionalized Adults with Intellectual Disabilities in Taipei City

Fang,

Hsieh,

Tsai

et al. 2023

Preprint

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Purpose To investigate the risk factors of ocular disorders among institutionalized adults with intellectual disabilities (ID) in Taipei City.Methods A cross-section city-wide ophthalmic survey was conducted in Taipei City from 2016 to 2017, involving full-time residents with ID aged over 18. Participant characteristics, including age, gender, ID severity, and associated diseases, were collected for multiple logistic regression analysis to identify ocular disorder risk factors.Results A total of 687 participants, comprising 70.9% of the eligible individuals, were included. Refractive errors (73.8%), strabismus (32.6%), ocular hypertension (26.0%) and cataract (15.3%) were the most common ocular disorders Myopia (73.2%) is the most common refractive error, with 14.6% being high myopia. DS was a common risk factor for developing strabismus (OR,2.54; 95% confidence interval (CI), 1.58 to 4.08), nystagmus (OR, 9.24; 95% CI, 4.41 to 19.37), high myopia (OR,2.54; CI, 1.52 to 4.25), high astigmatism (OR, 3.54; CI, 2.06 to 6.10), and cataracts (OR, 5.54; CI, 3.07 to 9.97). while it served as a protective factor against ocular hypertension (OR, 0.15; CI, 0.04 to 0.62). CP was identified as a common risk factor for strabismus (OR,2.09; CI, 1.28 to 3.42), nystagmus (OR,5.41; CI, 2.39 to 12.24), and high myopia (OR, 2.33; CI, 1.35 to 4.03).Conclusions High prevalence of myopia, strabismus, ocular hypertension and cataract was observed in institutionalized adults with ID. DS and CP were more significant risk factors than ID severity for ocular disorders. Regular ophthalmic exams, particularly monitoring intraocular pressure, are crucial for this population.

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“…This value was found, considering only studies that reported the percentage of ocular manifestations in the DS group. These studies were conducted by A et al [18], Akinci et al [19], Fimiani et al [20], Kim et al [21], Roizen et al [22], Terai et al [23], and Wong et al [24].…”

Section: Synthesis Of Resultsmentioning

confidence: 99%

Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature

Muñoz-Ortíz¹,

Charry-Sánchez²,

Bechara-Arango³

et al. 2021

Preprint

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Background: Down syndrome (DS) is a chromosomal anomaly that is characterized by an extra chromosome 21. Ophthalmological manifestations have a high prevalence in patients with DS.Purpose: To review the scientific evidence and estimate the prevalence of ophthalmological manifestations in the pediatric population with DS.Data Sources: Electronic databases including MEDLINE, Cochrane Library, EMBASE, ScienceDirect, and LILACS.Study Eligibility Criteria: Published observational studies with available and original data were included. Articles were excluded if the study design was a review, letter to the editor, case report, case series, or systematic review and if the subjects had ophthalmological manifestations secondary to other conditions.Participants and Interventions: Pediatric and adolescent population with DS and with ophthalmological evaluation.Study Appraisal and Synthesis Methods: A data collection form was designed in Excel. Five reviewers extracted relevant details about the design and results of each study. The quality of the studies was assessed by applying the tools of systematic reviews of prevalence and incidence of the Joanna Briggs Institute. We calculated the weighted prevalence of ophthalmological manifestations, considering only the studies reporting the measurement of each manifestation.Results: Twenty-two articles (from 15 countries, published during 1994–2020) were included in the present systematic review. Ocular manifestations were observed in 85% of the studied pediatric and adolescent populations with DS. The most frequent ones were slanting fissures, oblique fissures, epicanthus, and epiblepharon.Conclusion: The ocular manifestations in the pediatric and adolescent population with DS are varied, and some can irreversibly affect visual development. Screening of the pediatric population with DS should be conducted from the first months of age and continued annually.Systematic Review Registration Number: PROSPERO ID CRD42019127717

show abstract

Ocular findings in Japanese children with Down syndrome: the course of visual acuity and refraction, and systemic and ocular anomalies

Cited by 8 publications

References 25 publications

Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature

Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature

Risk Factors of Ocular Disorders among Institutionalized Adults with Intellectual Disabilities in Taipei City

Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature

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