Ocular findings in patients with psoriasis: is it related to the side effects of treatment or to psoriasis itself? A case-control study

Ghalamkarpour, Fariba; Baradaran‐Rafii, Alireza; Sadoughi, Mohammad Mehdi; Abdollahimajd, Fahimeh; Younespour, Shima; Zargari, Omid; Rudolph, Robert I.

doi:10.1080/09546634.2019.1577947

Cited by 28 publications

(49 citation statements)

References 26 publications

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“…Moreover, a significant correlation resulted between inflammatory markers, OSDI, and the Schirmer test. These findings are consistent with the idea of multiorgan inflammatory involvement in PsA disease sine-PsO [8,31] as demonstrated in other chronic inflammatory disorders, such as PsO [8][9][10][11][12][13], diabetes mellitus [32,33], and thyreopathies [34]. In this context, the presence of dry eye might reflect the inflammatory status being an indicator of the systemic involvement in PsA [35].…”

Section: Discussionsupporting

confidence: 87%

“…The presence of PsO may influence the occurrence of dry eye syndrome in PsA patients. As widely documented from both case-series studies and population-based studies, the presence of PsO is related to dry eye disease and its possible complications (as keratopathy) [10,11]. Dry-eye disease, in systemic inflammatory diseases, is associated with elevated levels of pro-inflammatory cytokines in tear film [12,13] Data concerning dry eye syndrome in PsA patients without PsO is lacking to date.…”

Section: Introductionmentioning

confidence: 99%

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A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine-Psoriasis: Evidence for a Potential Association with Systemic Inflammation

Chimenti

Triggianese

Salandri

et al. 2020

JCM

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Background: Ocular involvement in Psoriatic Arthritis (PsA) patients is mainly associated with uveitis but there remains a paucity of data on dry eye and retinal abnormalities. We aimed to analyze dry eye and subclinical retinal abnormalities in a cohort of PsA patients sine-psoriasis (PsO). Methods: PsA patients sine-PsO were enrolled. Best-corrected-visual-acuity, ocular-surface-disease-index (OSDI), Schirmer test, tear film breakup-time, standard-automated-perimetry (SAP, mean deviation—MD, pattern standard deviation—PSD), fundus-perimetry (FP), and spectral-domain-optical-coherence-tomography (SD-OCT) were performed. Results: A total of 80 eyes from 40 PsA patients with moderate-severe disease activity, and 70 eyes from 35 healthy control (HC) were evaluated. Higher dry eye prevalence occurred in PsA than HC (p < 0.0001). ESR was positively related with OSDI (p < 0.001) and negatively related with Schirmer (p = 0.007). In PsA, SAP registered higher MD (p < 0.0001) and higher PSD (p = 0.005) in comparison with HC. PSD resulted positively correlated with ESR (p = 0.04) and CRP (p = 0.01), while MD showed a negative correlation with CRP (p = 0.01). Both FP mean differential sensitivity and mean defect were lower in PsA then HC (p < 0.0001). In PsA, FP differential sensitivity was directly related with cumulative steroids (p = 0.02). Conclusions: In PsA patients sine-PsO, dry eye and subclinical abnormalities in visual functions occurred being potentially related to systemic inflammation.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine-Psoriasis: Evidence for a Potential Association with Systemic Inflammation

Chimenti

Triggianese

Salandri

et al. 2020

JCM

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“…Indeed, psoriasis is associated with a variety of comorbidities including metabolic syndrome, cardiovascular diseases (CVDs), inflammatory bowel diseases, and various other systemic conditions. [2][3][4][5][6][7][8][9][10] C-reactive protein (CRP) is a polypeptide and acute-phase reactant synthesized mainly by the hepatocytes during inflammation in response to certain cytokines, such as interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α. [11][12][13][14] High-sensitivity CRP (hs-CRP) can show small changes in CRP levels during inflammation; therefore, it is a much more sensitive marker than CRP.…”

Section: Introductionmentioning

confidence: 99%

High‐sensitivity C‐reactive protein as a biomarker in detecting subclinical atherosclerosis in psoriasis

Niknezhad

Haghighatkhah

Zargari

et al. 2020

Dermatologic Therapy

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Psoriasis is known to be associated with increased risk of cardiovascular diseases. High‐sensitivity C‐reactive protein (hs‐CRP) is a marker of inflammation and an independent risk factor for atherosclerosis. We aimed to assess the correlation between hs‐CRP and subclinical atherosclerosis in psoriatic patients. In 60 patients with moderate to severe psoriasis and 60 age‐ and gender matched healthy controls, we evaluated the serum hs‐CRP level and mean intima‐media thickness of the common carotid artery (MIMT‐CCA). Psoriatic patients had higher levels of hs‐CRP (median, 2.25 mg/L; IQR, 0.98‐3.80; and range, 0.29‐11.60) than did those in the control group (median, 1.03 mg/L; IQR, 0.36‐2.15; and range, 0.10‐3.35). Psoriatic patients also had higher mean MIMT (0.74 ± 0.19 and 0.54 ± 0.12, respectively, and P < .0001) compared with healthy subjects. The serum level of hs‐CRP was significantly correlated with MIMT (P < .0001). Our results indicate that psoriatic patients have a higher risk of subclinical atherosclerosis and hs‐CRP may be a useful marker for future risk of cardiovascular diseases in these patients. So, not only does anti‐inflammatory drugs play a key role in the treatment of psoriasis, but also they may reduce the risk of cardiovascular diseases by decreasing level of inflammatory markers including hs‐CRP.

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“…The remaining 7 seven studies were included in the meta-analysis. Of those, 2 studies [16,17] compared the incidence, and 5 studies [4,[18][19][20][21] compared the prevalence of uveitis between the psoriasis and nonpsoriasis groups. A flowchart describing the literature review and selection process is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Evaluation for publication bias using funnel plot was not performed due to the small number of included studies. [18] Radtke et al [20] Türkcü et al [21] Omar and Helaly [19] Ghalamkarpour et al [4] Percentage…”

Section: Risk Of Incident Uveitismentioning

confidence: 99%

Psoriasis and Risk of Uveitis: A Systematic Review and Meta-Analysis

Chaiyabutr

Ungprasert

Silpa‐archa

et al. 2020

BioMed Research International

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Background. Uveitis is a known ophthalmologic manifestation of seronegative spondyloarthropathy, including psoriatic arthritis. However, the data is less clear among patients with psoriasis due to the limited number of published studies. Aims. To investigate whether the risk of incident and prevalent uveitis is elevated among patients with psoriasis using systematic review and meta-analysis technique. Methods. The MEDLINE and EMBASE databases were searched from their inception to May 2019. Eligible studies must have included a psoriasis group and a nonpsoriasis group. Eligible studies must also have investigated for prevalent or incident uveitis, and the magnitude of difference between the study groups must have been reported. Pooled risk ratio and 95% confidence interval (CI) were calculated using random-effect generic inverse variance methods. Results. Of 7,107 potentially eligible articles from the EMBASE and MEDLINE databases, 7 studies were included in the meta-analysis. Two of those studies compared the incidence, and 5 studies compared the prevalence of uveitis between the psoriasis and nonpsoriasis groups. For incident uveitis, a total of 5,865,801 patients (222,083 with psoriasis and 5,643,718 without psoriasis) were analyzed. For prevalent uveitis, a total of 1,343,436 patients (37,891 with psoriasis and 1,305,545 without psoriasis) were studied. The risk of incident uveitis was significantly higher among patients with psoriasis with a pooled risk ratio of 1.23 (95% CI: 1.05-1.45, I2=55%). The risk of prevalent uveitis was also significantly higher among patients with psoriasis with a pooled risk ratio of 1.97 (95% CI: 1.68-2.31, I2=0%). Conclusions. The results of this study revealed significantly increased risk of both prevalent and incident uveitis among patients with psoriasis.

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Ocular findings in patients with psoriasis: is it related to the side effects of treatment or to psoriasis itself? A case-control study

Cited by 28 publications

References 26 publications

A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine-Psoriasis: Evidence for a Potential Association with Systemic Inflammation

A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine-Psoriasis: Evidence for a Potential Association with Systemic Inflammation

High‐sensitivity C‐reactive protein as a biomarker in detecting subclinical atherosclerosis in psoriasis

Psoriasis and Risk of Uveitis: A Systematic Review and Meta-Analysis

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