1970
DOI: 10.1136/bjo.54.2.73
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Ocular findings in thrombotic thrombocytopenic purpura (Moschcowitz's disease).

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Cited by 59 publications
(28 citation statements)
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“…This is a rare ocular complication of TTP, which can develop, mostly late, in the course of the disease. [9][10][11] Retinal detachment is thought to occur due to localized ischaemic injury to the retinal pigment epithelium, caused by microthrombi in the small choroidal vessels, which inhibits adequate transport of fluid from the subretinal space. 11 Our patient regained complete vision by treatment with plasma exchange therapy.…”
Section: Resultsmentioning
confidence: 99%
“…This is a rare ocular complication of TTP, which can develop, mostly late, in the course of the disease. [9][10][11] Retinal detachment is thought to occur due to localized ischaemic injury to the retinal pigment epithelium, caused by microthrombi in the small choroidal vessels, which inhibits adequate transport of fluid from the subretinal space. 11 Our patient regained complete vision by treatment with plasma exchange therapy.…”
Section: Resultsmentioning
confidence: 99%
“…Anisocoria, subconjunctival hemorrhage, scintillating scotoma and extra-ocular muscle paresis may be present. 12 Homonymous hemianopia and optic atrophy may also be seen if vessels supplying optic nerve are involved.…”
Section: Thrombotic Thrombocytopenic Purpura (Ttp)mentioning
confidence: 99%
“…[1][2][3] Although this feature has been described before, previous cases were reported to occur after systemic signs of TTP were established. [4][5][6] Thrombotic thrombocytopenia purpura has an incidence of 3.7 per million, occurring most frequently in young female adults. In many cases remission is achieved and so the prevalence is increasing.…”
Section: Commentmentioning
confidence: 99%
“…TTP is caused by platelet thrombi principally in the renal and cerebral circulations and aggregations can also occur in the choroidal circulation with overlying serous fluid in the subretinal space. 4 The cause is thought to be from excessive platelet aggregation mediated by ultralarge von Willebrand Factor (ULVWF) multimers caused by a failure of the proteolytic action of metalloproteinases, such as ADAMTS 13, in affected patients. 7 Unexplained patchy serous retinal detachment should prompt investigation for TTP with a full blood count …”
Section: Commentmentioning
confidence: 99%