Ocular Forward Light Scattering and Corneal Backward Light Scattering in Patients With Dry Eye

Koh, Shizuka; Maeda, Naoyuki; Ikeda, Chikako; Asonuma, Sanae; Mitamura, Hayato; Oie, Yoshinori; Soma, Takeshi; Tsujikawa, Motokazu; Kawasaki, Satoshi; Nishida, Kohji

doi:10.1167/iovs.14-15125

Cited by 57 publications

(49 citation statements)

References 43 publications

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“…It was presumed that the MTF values after Femto-LASIK are more likely affected by tear film quality than those after SMILE surgery. A study shows that ocular forward light scattering from the anterior cornea was greater in dry eyes than in normal eyes [18]. Thus, in this study, we can find that the ΔStrehl ratio in Femto-LASIK shows less change than in SMILE group during the follow-up time.…”

Section: Discussionsupporting

confidence: 50%

Comparison of the Optical Quality between Small Incision Lenticule Extraction and Femtosecond Laser LASIK

Jin

Wang

et al. 2016

Journal of Ophthalmology

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Purpose. To investigate the visual quality after SMILE and Femto-LASIK. Methods. About 123 eyes from 63 patients were enrolled in this study. The parameters were measured preoperatively and 1 week, 1 month, and 3 months postoperatively using Sirius System. Results. The MTF curve increase slightly from low to high frequency at 3 mm and 6 mm pupil diameter after SMILE surgery (P < 0.05) during the follow-up time comparing with the preoperative values. And the SR has a significant increase at various pupil diameters as well (P < 0.05). However, there was little increase for MTF at intermediate to high frequency at 3 mm pupil diameter after Femto-LASIK procedure (P < 0.05). And the SR had only significant increase at 3 mm pupil diameter. Between SMILE and Femto-LASIK, there was no statistic difference both in MTF and SR (P > 0.05) at 3 mm pupil diameter at vertical and horizontal meridian. However, significant difference was found in MTF at low to mediate frequency at 6 mm pupil diameter at vertical meridian at 1 week postoperatively (P < 0.05). Conclusions. Both SMILE and Femto-LASIK show a great improvement in optical quality at small diameter. It was found that SMILE shows better optical quality than Femto-LASIK at larger pupil diameter, which might be good for the night vision.

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Section: Discussionsupporting

confidence: 50%

Comparison of the Optical Quality between Small Incision Lenticule Extraction and Femtosecond Laser LASIK

Jin

Wang

et al. 2016

Journal of Ophthalmology

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“…We used the data set of healthy subjects whose straylight data were previously reported. 16 We used 20 eyes of 20 age-matched healthy subjects with no ocular pathology except any refractive errors as a control group. In both dry eye and normal groups, all eyes had a best-corrected distance visual acuity better than 20/20.…”

Section: Patient Populationmentioning

confidence: 99%

“…8 Straylight is known to be a cause of disability glare [9][10][11] and corneal pathologic conditions may produce increased straylight. 12 Decreased contrast sensitivity [13][14][15] and increased straylight 16,17 in dry eye has been reported; however, little is known about the effects of ocular surface regularity in the central corneal region on contrast sensitivity and straylight.…”

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confidence: 99%

The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

Koh

Maeda

Asonuma

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…4 Dry eye causes eye irritation, hyperemia, glare, eye fatigue, and blurred vision. Vision impairment in dry eye is due to the increased higher-order aberrations, 5,6 or superficial punctate keratitis, 7 and in severe cases, such as graft-versus-host disease (GVHD) or Stevens-Johnson syndrome (SJS), blindness from corneal opacification or ulceration may result. 8,9 Tear instability in dry eye is caused by a variety of conditions; aqueous deficiency due to lacrimal gland atrophy, lipid abnormalities associated with Meibomian gland dysfunction (MGD), and excessive tear evaporation.…”

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confidence: 99%

Inflammatory Response in Dry Eye

Yamaguchi

2018

Invest. Ophthalmol. Vis. Sci.

193

120

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PURPOSE. Dry eye is a major ocular pathology worldwide. Although dry eye is a multifactorial disease, recent studies have shown that chronic immunologic processes have a pivotal role in its pathogenesis, characterized by the infiltration of immune cells in the lacrimal glands, elevated levels of tear inflammatory cytokines, and increased density of immune cells in the cornea and conjunctiva. This review describes the recent advances in understanding the relationship between dry eye and inflammation. METHODS. This narrative review is based on searches of recent international literature using terms related to the immune response in dry eye, and includes clinical trials, animal experiments, and expert reviews. RESULTS. Although dry eye presents clinically as tear film instability associated with corneal/ conjunctival epithelial disorders, Meibomian gland dysfunction, and decreased visual function, recent laboratory and clinical studies have indicated inflammation in the lacrimal glands, Meibomian glands, conjunctiva, cornea, and aqueous tears. Furthermore, inflammation at these locations leads to conjunctival goblet cell apoptosis, corneal epithelial barrier disruption, and corneal nerve damage. These inflammatory outcomes can be exacerbated by intrinsic and extrinsic factors, such as aging, sex steroid hormone, autoimmune diseases, contact lens use, visual display terminals, and dry environment. CONCLUSIONS. Recent advances in dry eye research have revealed the inflammatory process and its pathogenesis, which has been proposed as an ''inflammatory vicious cycle'' of dry eye. Comprehensive assessment of dry eye based on inflammation will improve the selection of treatments and help break the inflammatory cycle in clinical settings.

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Ocular Forward Light Scattering and Corneal Backward Light Scattering in Patients With Dry Eye

Abstract: Ocular forward light scattering and corneal backward light scattering from the anterior cornea were greater in dry eyes than in normal eyes. Increased corneal backward light scattering in dry eye at least partially results from cSPK overlying the optical zone.

Cited by 57 publications

References 43 publications

Comparison of the Optical Quality between Small Incision Lenticule Extraction and Femtosecond Laser LASIK

Comparison of the Optical Quality between Small Incision Lenticule Extraction and Femtosecond Laser LASIK

The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

Inflammatory Response in Dry Eye

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