Ocular Graft Versus Host Disease: Just a Severe Form of Dry Eye or Something More?

Murillo, Sofia; Soifer, Matias; Pérez, Víctor L.

doi:10.1007/s40135-022-00281-9

Cited by 1 publication

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic oGVHD is due to increase in number of stromal CD34 β fibroblasts as well as infiltration of T cell causing inflammatory destruction of conjunctiva and lacrimal gland with fibrosis. KCS or dry eyes is the most common ocular manifestation of chronic oGVHD along with inflammatory signs like conjunctival edema, chemosis, membrane formation and Meibomian gland dysfunction (MGD) [6,25,35] . As mentioned above, all patients who were diagnosed with oGVHD had dry eye disease irrespective of differences in conditioning regimen.…”

Section: Ocular Manifestation Of Graft Versus Host Diseasementioning

confidence: 99%

See 1 more Smart Citation

Incidence of ocular manifestations in patients with graft versus host disease after allogeneic stem cell transplant in Riyadh, Saudi Arabia

Aldebasi¹,

Gangadharan²,

Shaheen³

et al. 2022

Int J Ophthalmol

View full text Add to dashboard Cite

AIM: To evaluate the incidence and severity of ocular graft versus host disease (oGVHD) in patients who underwent allogeneic stem cell transplant (SCT) in King Abdul-Aziz Medical City, Saudi Arabia. METHODS: This is a retrospective cohort study conducted in King Abdul Aziz Medical City on patients who underwent allogeneic hematopoietic cell transplant (allo-HCT) from 2010 to 2017. The ocular examination findings including visual acuity, meibomian gland dysfunction, corneal and conjunctival staining with severity, corneal scarring, tear film meniscus and breakup time, anterior and posterior segment examination findings, intraocular pressure, treatment given, punctual plugs used or not, and follow up response were collected. RESULTS: The five years cumulative incidence of oGVHD among post-transplant patients was 56.98% (95%CI 38.6%-71.7%). The potential risk factors assessed for developing ocular manifestation were age, gender, donor’s age, donor gender mismatch CD3 and CD34 infusion, while none of the correlates were identified as statistically significant risk factors of developing ocular manifestation. However, the incidence was statistically significantly different between patients diagnosed with acute myelocytic leukemia and acute lymphocytic leukemia (P=0.038). The mean latent period to develop ocular symptoms was 20.5mo. All patients had variable degree of dry eyes. None of the patients developed any posterior segment complication. CONCLUSION: The incidence of oGVHD is low in King Abdul-Aziz Medical City. This can be attributed to the preconditioning and immunosuppressive regime.

show abstract

Section: Ocular Manifestation Of Graft Versus Host Diseasementioning

confidence: 99%

“…The common sites involved in chronic GVHD in order of frequency are skin (75%), mouth (51%-63%) and liver (29%-51%) [6][7] . Literature shows that 50%-90% of transplant recipients with systemic GVHD have ocular complication [8][9] .…”

Section: Introductionmentioning

confidence: 99%