Ocular histoplasmosis syndrome

Diaz, Rocio I.; Sigler, Eric J.; Rafieetary, Mohammad; Calzada, Jorge I.

doi:10.1016/j.survophthal.2015.02.005

Cited by 51 publications

(41 citation statements)

References 132 publications

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“…After initial exposure to the fungus, patients may develop mild flu-like symptoms and asymptomatic calcified pulmonary nodules. Patients typically complain of visual symptoms including vision loss, metamorphopsia, and paracentral scotomata years following the resolution of the systemic infection when choroidal neovascularization (CNV) develops [34]. …”

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confidence: 99%

Multi-modal imaging and anatomic classification of the white dot syndromes

et al. 2017

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The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morphology, the activity and age of lesions, and whether there is CNV associated with these different ocular pathologies. The “white dot syndromes” and their uveitic masqueraders can now be anatomically categorized based on lesion localization. The categories include local uveitic syndromes with choroidal pathology, systemic uveitic syndromes with choroidal pathology, and multifocal choroiditis with outer retinal/choriocapillaris pathology with uveitis and without uveitis. Neoplastic and infectious etiologies are also discussed given their ability to masquerade as WDS.

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Section: Main Textmentioning

confidence: 99%

Multi-modal imaging and anatomic classification of the white dot syndromes

et al. 2017

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“…Obviously, the choroid is a very interesting target. Many diseases cause neovascularisation of choroidal vessels leading to bad prognosis, such as AMD (the wet form)57, myopic macular degeneration58, uveitis59, presumed ocular histoplasmosis syndrome60, and angioid streaks61. It is obvious that the prevention or reduction of neovascularisation is the first aim in the treatment of degenerative ocular diseases; however, a specific drug targeting to the choroid is missing.…”

Section: Discussionmentioning

confidence: 99%

Magnetic nanoparticles: a strategy to target the choroidal layer in the posterior segment of the eye

Giannaccini

Pedicini

Matienzo

et al. 2017

Sci Rep

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Despite the higher rate of blindness due to population aging, minimally invasive and selective drug delivery to the eye still remains an open challenge, especially in the posterior segment. The retina, the retinal pigment epithelium (RPE) and the choroid are posterior segment cell layers, which may be affected by several diseases. In particular, damages to the choroid are associated with poor prognosis in the most severe pathologies. A drug delivery approach, able to target the choroid, is still missing. Recently, we demonstrated that intravitreally injected magnetic nanoparticles (MNP) are able to rapidly and persistently localise within the RPE in an autonomous manner. In this work we functionalised the MNP surface with the vascular endothelial growth factor, a bioactive molecule capable of transcytosis from the RPE towards more posterior layers. Such functionalisation successfully addressed the MNPs to the choroid, while MNP functionalised with a control polypeptide (poly-L-lysine) showed the same localisation pattern of the naked MNP particles. These data suggest that the combination of MNP with different bioactive molecules could represent a powerful strategy for cell-specific targeting of the eye posterior segment.

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“…Over the course of time the lesions evolve into atrophic, partially pigmented chorioretinal scars, making them indistinguishable from lesions due to presumed ocular histoplasmosis syndrome (POHS) [1,4,6]. Although POHS classically presents with more punched-out choroidal scars in the mid-periphery and with concurrent peripapillary atrophy [6,7], it is sometimes difficult to differentiate PIC and POHS lesions [1,4,8].…”

Section: Introductionmentioning

confidence: 99%

“…Although POHS classically presents with more punched-out choroidal scars in the mid-periphery and with concurrent peripapillary atrophy [6,7], it is sometimes difficult to differentiate PIC and POHS lesions [1,4,8]. However, diagnosis of ocular histoplasmosis should be reserved for patients with residence in an area endemic for the fungus Histoplasma capsulatum.…”

Section: Introductionmentioning

confidence: 99%

“…5 months on average (SD 5.5, range[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Although the eyes treated by ranibizumab (n = 2) had a slightly better functional outcome (DBCVA ?1.5 lines) compared to the eyes injected with bevacizumab (n = 13, DBCVA ?0.77 lines), no conclusion can be drawn about the superiority of one of the anti-VEGF agents because of the low sample sizes.Visual acuity, refraction and functional outcomeThe refractive error was recorded in 13 (81%) eyes with a mean spherical equivalent of -4.3 dioptres (D) (SD 3.1 D, range -7.0 to 0.5 D).…”

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confidence: 99%

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