Ocular Hypotensive Effect of Topical Verapamil and Diltiazem in Steroid Induced Glaucoma Model of Rabbits

The effect of Calcium channel blocker in the Betamethasone-induced Glaucoma model in rabbits

“…The beneficial effect of blocking calcium channels in treating glaucoma can also be attributed to the reduction of vascular resistance, which increases the speed of blood in the capillaries of the optic nerve head [29]. The findings of our research, by previous studies, showed the IOP reduction behavior of the application of topical CCBs [9,18].…”

“…Panchal and the team in one experiment using chronic glaucoma models also show a good reduction in the IOP after 2 hours of topical administration of CCBs [17]. Prabhakar and co-workers display a topical administration of Diltiazem 0.5% and verapamil 0.1% decrease the IOP in steroid-induced glaucoma model of rabbits [18]. Furthermore, another study the Prabhakar shows a good oculo-hypotensive action of orally administered Amlodipine in a patient with IOP of more than 25 mmHg [19].…”

“…Besides, by inhibiting endothelin-1, CCB can enhance blood flow in the eye. [18][19][20][21] Nevertheless, the impact of CCB on IOP stays debatable [22]. Calcium inflows may perhaps have many effects on the dynamics of aqueous humor, which include ciliary body perfusion, a hydrostatic element created by the pressure of the blood, and an osmotic component induced by ciliary epithelium on active sodium, calcium, and other ions secretions [7].…”