Ocular Involvement in Epstein-Barr Virus-associated T-cell Lymphoma

Cochereau, Isabelle; Hannouche, D; Geoffray, C; Toublanc, M.; Hoang–Xuan, T.

doi:10.1016/s0002-9394(14)70284-3

Cited by 17 publications

(6 citation statements)

References 5 publications

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“…The origin of atypical B lymphocytes inside the eye is still questioned in this disease [8]. In addition to typical features of vitreous and subretinal and sub-RPE infiltration, other rare ocular presentations reported for PVRL are vitreous hemorrhages, retinal vasculitis, optic nerve infiltration, and rarely serous retinal detachment [9]. Despite having had RRD surgically repaired, our patient's PVRL appearance was typical.…”

Section: Discussionmentioning

confidence: 66%

Clinical sign and symptom of primary vitreoretinal lymphoma short-time after retinal reattachment surgery: a case report

Fooladi

Amini

Riazi-Esfahani

et al. 2022

J Ophthal Inflamm Infect

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Purpose To describe a case of primary vitreoretinal lymphoma (PVRL), initially presented after successful repair of rhegmatogenous retinal detachment (RRD). Case presentation A 65-year-old man underwent pars plana vitrectomy with silicone oil tamponade for total RRD with grade C proliferative vitreoretinopathy in the right eye. Ten months after silicon oil removal, the patient presented with weakened vision, and multiple small yellow sub-retinal elevations was observed in fundus examination and optical coherence tomography (OCT). A cytopathologic examination of the vitreous showed lymphoid cell infiltration with nuclear atypia, which is strongly indicative of malignant lymphoma. Subretinal lesions continued with no noticeable improvement after 9 sessions of 400 microgram methotrexate therapy. Conclusion We identified the presentation of PVRL in a vitrectomized eye and the response to treatment in this article.

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Section: Discussionmentioning

confidence: 66%

Clinical sign and symptom of primary vitreoretinal lymphoma short-time after retinal reattachment surgery: a case report

Fooladi

Amini

Riazi-Esfahani

et al. 2022

J Ophthal Inflamm Infect

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“…The most characteristic feature of PVRL is the yellowish white/orange subretinal infiltrates that may enlarge and coalesce over time (Figure 2A,B,C) (27). Moreover, other abnormalities like hemorrhages, retinal vasculitis, optic nerve infiltrates, and/or serous retinal detachment can occur (6,28). In addition to the posterior segment involvement, some patients initially develop some anterior segment manifestations, including corneal edema, hypopyon, pupil distortion and/or iritis (29).…”

Section: Clinical Features Of Pvrlmentioning

confidence: 99%

Case 01-2017—Primary vitreoretinal lymphoma (PVRL): report of a case and update of literature from 1942 to 2016

2018

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Primary vitreoretinal lymphoma (PVRL), as a subset of primary central nervous system lymphoma (PCNSL), is a rare and fatal ocular malignancy. Most PVRL masquerades as chronic posterior uveitis, which makes the clinical diagnosis challenging. Vitreous cells, subretinal lesions and imaging techniques are essential for clinical diagnosis. Importantly, cytopathology/histopathology identification of malignant cells is the gold standard for the diagnosis of PVRL. In addition, molecular detection of immunoglobulin heavy chain (IgH) or T cell receptor (TCR) gene rearrangements, immunophenotyping for cell markers, and cytokine analysis of interleukine-10 elevation are often used as adjunct procedures. Current management of PVRL involves local radiation, intravitreal chemotherapy (methotrexate and rituximab), with or without systemic chemotherapy depending on the involvement of non-ocular tissues. In cases with concomitant PCNSL, systemic high-dose methotrexate/rituximab based therapy in conjunction with local therapy, whole brain radiotherapy and/or autologous stem cell transplantation is considered. Although PVRL normally responds well to initial treatment, high rates of relapse and CNS involvement usually lead to poor prognosis and limited survival. A professional team of medical experts in ophthalmologists, ocular pathologists, neuro-oncologists and hemato-oncologists is essential for optimizing patient management.

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“…Intraocular lymphoma resembling PCNSLO has been seen in patients infected with human T-cell lymphotropic virus-1 (HTLV-1) and Epstein-Barr virus. 46,47 …”

Section: Immunosuppression Viral Infection and Pcnslomentioning

confidence: 99%

Intraocular Lymphoma

Bardenstein

1998

Cancer Control

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Background Primary ocular lymphoma is a distinct subtype of intraocular lymphoma. Its clinical presentation can mimic benign conditions. Diagnosis is often based on obtaining an intraocular biopsy. Optimal management is not yet realized. Methods This report combines the experience of the author with a review of the current literature pertaining to intraocular lymphoma. Results Primary ocular lymphoma, a subtype of primary central nervous system (CNS) lymphoma, has a variable clinical course and frequently mimics benign inflammatory disease. Even when suspected, diagnosis can be elusive. Chemoradiation is the most effective treatment, but significant ocular and cerebral morbidity is associated with its use. Novel treatment regimens may reduce or eliminate side effects while preserving life, vision, and CNS function. Conclusions Primary CNS lymphoma with ocular involvement should be considered in patients with refractory uveitis, yellow-white choroidal masses, and CNS lymphoma. Aggressiveness in making the diagnosis should be tempered by the potential complications of the diagnostic process and advanced by the life-threatening nature of the disease. Treatment should attempt to maximize efficacy while incorporating considerations such as extent of disease and the patient's age, health, and mental state.

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Ocular Involvement in Epstein-Barr Virus-associated T-cell Lymphoma

Cited by 17 publications

References 5 publications

Clinical sign and symptom of primary vitreoretinal lymphoma short-time after retinal reattachment surgery: a case report

Clinical sign and symptom of primary vitreoretinal lymphoma short-time after retinal reattachment surgery: a case report

Case 01-2017—Primary vitreoretinal lymphoma (PVRL): report of a case and update of literature from 1942 to 2016

Intraocular Lymphoma

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