Ocular Manifestation of Systemic Lupus Erythematosus – A Clinical Study

Abstract

Aim: To determine the various ocular manifestations of SLE for early diagnosis, prompt initiation of therapy and better prognosis of SLE cases. A total of 50 diagnosed patients of SLE attending RIO a Materials And Methods: nd department of Dermatology, GMCH were selected for the study. Detailed history and a thorough ocular examination was performed. Laboratory investigations including R/E blood, ESR, RBS, R/E urine, 24 hours urinary protein, RFT and ANA were done. Results And Observations: Incidence of ocular manifestations of SLE was 70%. The mean age of presentation was 32.2 years. The female: male was 11.5:1. The median duration of illness was 1.75 years. The commonest systemic involvement was hematological(90%), followed by cutaneous(64%), musculoskeletal(60%), renal(42%), serosal(4%), neurological(2%). 72% had SLEDAI score ≤10 and 28% had >10. Anterior segment involvement(58%) is more than posterior segment(12%). Common anterior segment manifestations were Keratoconjunctivitis sicca, PSC, eyelid lesions, ulcerative blepheritis, subconjunctival haemorrhage, periorbital oedema, PUK, episcleritis. Posterior segment manifestations were lupus retinopathy, hypertensive retinopathy, CSCR, CRVO, optic atrophy and pigmentary maculopathy. 56% were on steroid therapy, 36% were on steroid+HCQS and 8% were on steroid+cyclophosphamide. SLE is a multisyst Conclusion: em disease with varied manifestations and diagnosis depends upon careful evaluation of all the systems including the eye. The ophthalmologist may play an important role in the care of the SLE patients, since ocular inammatory lesions may precede potentially serious extraocular disease and may guide towards the diagnosis.