Ocular manifestations and treatment of Lyme disease

Mikkilä, Helena

doi:10.1097/00055735-199606000-00002

Cited by 23 publications

(12 citation statements)

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“…7 Immunoblot, or alternatively the detection of B. burgdorferi by DNA polymerase chain reaction, may help in diagnosing Lyme disease with a routine seronegative ELISA. 5 In our patient, immunoblotting confirmed the diagnosis before treatment. This issue is interesting because immunoblots can be negative after prolonged antibiotic treatment, despite the persistence of symptoms and the presence of microorganisms in the orbital tissue.…”

Section: Discussionsupporting

confidence: 69%

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Oculopalpebral Borreliosis as an Unusual Manifestation of Lyme Disease

Murillo¹,

Ramírez²,

Romo³

et al. 2013

Cornea

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Section: Discussionsupporting

confidence: 69%

“…1 This clinical expression of LB is unusual in other sites, and ocular manifestations are considered rare. 5 An atypical case of facial ACA has been previously reported. 6 The clinical features described were similar to the lesion in the eyelid skin of our patient.…”

Section: Discussionmentioning

confidence: 95%

Oculopalpebral Borreliosis as an Unusual Manifestation of Lyme Disease

Murillo¹,

Ramírez²,

Romo³

et al. 2013

Cornea

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“…Oküler lezyonlarda Jarisch-Herxheimer reaksiyonu sifilis, Whipple hastal›¤›, leptospirozis ve Lyme hastal›¤› ile de rapor edilmifltir. [54][55][56][57] ATT ile paradoksik kötüleflme oküler TB'da ve özellik-le serpijinöz benzeri koroidit tablosunda bildirilmifltir. [49][50][51] 4.…”

Section: Subretinal Abseunclassified

Oküler Tüberküloz I: Epidemiyoloji, Patogenez ve Klinik Özellikler

Onal¹,

Tutkun²

2011

Tjo

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ÖzetDünya Sa¤l›k Örgütü tüberküloz (TB) enfeksiyonunu morbidite ve mortalitenin en s›k nedeni olmas› sebebi ile global bir acil olarak ilan etmifltir. TB aside dayan›kl› bir basil olan Mycobacterium tuberculosis'in yol açt›¤› bir enfeksiyon olup genellikle akci¤er dokusunu etkiler [pulmoner TB (PTB)]. Ancak vücudun di¤er organ ve sistemlerinde de hastal›¤a yol açabilmektedir [Ekstrapulmoner TB (EPTB)]. PTB olan hastalar›n %1,4'ünde oküler bulgular›n geliflece¤i tahmin edilmektedir, buna karfl›n oküler TB olan hastalar›n ço¤unda PTB saptanamamaktad›r. Oküler mikobakterium tüberkülozis enfeksiyonu PTB veya EPTB'nin hematojen yay›l›m›n›n sonucudur. Semptomatik hastal›k birincil enfeksiyondan ziyade genellikle oküler dokuda canl›l›¤›n› sürdürmüfl olan sessiz lezyonlar›n reaktivasyonu yolu ile gerçekleflir. Ayr›ca immunarac›l›kl› oküler TB uzak bir odakta (örne¤in akci¤er) yer alan mikobakterium tüberkülozis antijenlerine karfl› afl›r› duyarl›l›k nedeni ile meydana gelebilir. Bu afl›r› duyarl›l›k bakteri gözde bulunmad›¤› halde inflamasyon ile neticelenir. TB'a ba¤l› intraoküler inflamasyon (üveit) prezentasyonlar› içinde en s›k olarak gözleneni arka üveit olup bunu s›ras› ile ön üveit, panüveit ve intermediyer üveit takip etmektedir. ‹ntraoküler TB tan›s› için standardize edilmifl tan›sal kriterlerin olmamas› nedeni ile tan› ve tedavi konusunda zorluklar bulunmaktad›r. Son dönemlerde saflaflt›r›lm›fl protein türevi (PPD) deri testi, interferon gama sal›n›m analizleri, toraks›n bilgisayarl› tomografisi ve polimeraz zincir reaksiyonu ile ilgili yap›lm›fl çal›flmalar oküler TB tan›s›n›n konulmas›nda yeni yaklafl›mlar›n do¤mas›na neden olmufltur. Bu derleme serisi, güncel literatür ›fl›¤›nda klinik özellikler, tan›sal yaklafl›mlar, tan›sal kriterler ve tedavi üzerinde yo¤unlaflmaktad›r. (Turk J Ophthalmol 2011; 41: 171-81) Anahtar Kelimeler: Tüberküloz, göz tutulumu, üveit, tan›, tedavi SummaryThe World Health Organization has declared tuberculosis (TB) to be a global emergency, as it remains the most common single cause of morbidity and mortality worldwide. TB is caused by the acid-fast bacillus Mycobacterium tuberculosis and primarily affects the lungs [pulmonary TB (PTB)]. It can also affect any other part of the body [extrapulmonary TB (EPTB)]. It is estimated that 1.4% of patients with PTB will eventually develop ocular disease; however, in the majority of cases of ocular TB, PTB may not be documented. Ocular TB infection is usually a result of hematogenous spread during PTB or EPTB. Symptomatic disease most commonly develops after reactivation of dormant foci in the ocular tissue rather than being the manifestation of the initial infection. Immune-mediated ocular TB can occur due to hypersensitivity to M. tuberculosis antigens from a distant focus (such as lungs), despite the absence of the bacterium in the eye. The most common clinical presentation of intraocular inflammation (uveitis) due to TB appears to be posterior uveitis, followed by anterior uveitis, panuveitis and intermediate uveitis. The absence of unif...

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“…3 Ocular manifestations are less common, but has been described as retinal vasculitis in Whipple's disease. 4 Proposed mechanisms include endotoxin release from the death of organisms, delayed hypersensitivity, and decreased suppressor mechanisms.…”

Section: Commentmentioning

confidence: 99%

“…Reduced corneal diameter and peripheral corneal changes similar to aniridia [1][2][3] can occur in iris coloboma. We present a case of iris coloboma in which photorefractive keratectomy (PRK) was performed.…”

mentioning

confidence: 99%