Ocular Manifestations in Children Born After In Vitro Fertilization

Abstract

To report the ocular abnormalities found in children born after in vitro fertilization. Methods: Forty-seven children (25 girls and 22 boys) born after an in vitro fertilization pregnancy (mean±SD birth weight, 2335 ± 817 g; range, 924-4300 g) and referred for ophthalmic evaluation were included in the study. All underwent a thorough ocular examination. Obstetric history was gathered following a detailed questionnaire with the mothers. Results: Of 70 eyes among nonverbal children, visual acuity was "normal for age" in 60 (86%), "fair" in 4 (6%), and "poor" in 6 (9%). Visual acuity in 24 eyes in verbal children ranged from 6/6 to no light perception, with 4 (17%) having poor vision. Cycloplegic refraction disclosed an emmetropia in 22 (27%), hypermetropia in 47

Perinatal outcome, health, growth, and medical care utilization of 5- to 8-year-old intracytoplasmic sperm injection singletons

“…In our study ocular developmental defects seemed increased after ICSI as compared to NC controls, but the validity of this result is poor. An increase in ocular malformations and retinoblastoma after artificial reproduction has been reported previously (42,43).…”

Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing

“…ART-associated Angelman syndrome has been reported (21,(25)(26)(27), corresponding with hypomethylation at the SNRPN imprinting control region. Retinoblastoma has also been reported after ART (28)(29)(30). The Retinoblastoma gene, RB1, is imprinted (31), indicating that assessment of RB1 methylation in preimplantation development and ART-associated retinoblastoma cases may be pertinent.…”

CAG repeat length in an infertile male population of Irish origin

“…Recently, medically assisted reproductive technology (MART) has been placed under the spotlight; due to the increased risk that offspring conceived as a result of MART will develop disorders (Blickstein & Weissman, 1999;Anteby et al, 2001;De Baun, Niemitz & Feinberg, 2003;Kurinczuk, 2003). It may be prudent to screen for the CAG repeat length of the AR gene until the relevance of AR CAG repeat length to depressed spermatogenesis is fully understood.…”