Ocular manifestations of dengue fever in an East Indian epidemic

New associations of classic acute macular neuroretinopathy

“…The appearance of classic AMN lesions in these disease entities has never been described so far. Marked thrombocytopenia has been associated with ocular findings in dengue fever, whereas anaemia, thrombocytopenia and hyperviscosity have been associated with ocular findings in leukaemia 6 9. Increased capillary permeability, endothelial dysfunction and haemorrhagic diathesis, platelet destruction, occlusion of precapillary arterioles by immune complex deposition as well as consumptive coagulopathy have been proposed as a cause of the associated retinal findings in these entities and may also be the leading cause of focal ischaemia of the deep capillary network in our patients 6.…”

Prevalence of Retinal Hemorrhages in Critically Ill Children

“…15 Despite this, other than a handful of case reports and few small case series, there are no specific studies determining such an association. 16,17,[28][29][30][31][32] Leukemia is known to cause significant retinopathy in as many as two-thirds of the patients with myeloid leukemia 33 ; we saw severe RH in 3 patients with myeloid leukemia and severe sepsis. Other than the retinal lesions caused by leukemic infiltrates, the RHs in leukemia are thought to be associated with coagulation and platelet abnormalities.…”

Novel infectious agents causing uveitis

“…Ocular involvement in dengue fever has recently been reported from Singapore, Thailand, Taiwan, India, Mexico and Brazil [66][67][68][69][70][71][72][73][74][75][76]. In a cross-sectional observational study conducted in Singapore in 2005 during a dengue epidemic [77], we found that the prevalence of dengue maculopathy among patients hospitalized for dengue fever was 10%.…”

“…The commonest ocular involvement reported in an East Indian population was a petechial type of subconjunctival hemorrhage (37%), which was associated with a platelet count of \50,000/ll [73].…”