Ocular manifestations of inflammatory bowel diseases: an update for gastroenterologists

Castellano, Fabio; Alessio, Giovanni; Palmisano, Carmela

doi:10.23736/s2724-5985.20.02727-0

Cited by 3 publications

(5 citation statements)

References 69 publications

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“…It mainly includes two subtypes of ulcerative colitis (UC) and Crohn's disease (CD) [ 7 ]. The disease not only affects the gastrointestinal system but also has a wide range of extraintestinal manifestations such as the eyes [ 8 ], skin [ 9 ], and joints [ 10 ]. In addition, patients with IBD have an increased risk of cardiovascular disease [ 11 ], Parkinson's disease [ 12 ], cerebrovascular disease [ 13 ], diabetes [ 14 ], psychosis, and suicide [ 14 ], in which all seriously affect the quality of life of patients and cause a huge economic burden.…”

Section: Introductionmentioning

confidence: 99%

Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier

Tian

Zhang

2022

Gastroenterology Research and Practice

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Inflammatory bowel disease is a group of chronic, recurrent, nonspecific inflammatory diseases of the intestine that severely affect the quality of life of patients. The pathogenesis of this disease is caused by complex and interactive neural networks composed of factors such as genetic susceptibility, external environment, immune disorders, and intestinal barrier dysfunction. It is well known that there is a strong link between environmental stressors (also known as circadian clocks) that can influence circadian changes and inflammatory bowel disease. Among them, the biological clock is involved in the pathogenesis of inflammatory bowel disease by affecting the function of the intestinal barrier. Therefore, this review is aimed at systematically summarizing the latest research progress on the role of the circadian clock in the pathogenesis of inflammatory bowel disease by affecting intestinal barrier functions (intestinal mechanical barrier, intestinal immune barrier, intestinal microecological barrier, and intestinal chemical barrier) and the potential clinical value of clock genes in the management of inflammatory bowel disease, for the application of circadian clock therapy in the management of inflammatory bowel disease and then the benefit to the majority of patients.

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Section: Introductionmentioning

confidence: 99%

Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier

Tian

Zhang

2022

Gastroenterology Research and Practice

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“…IBD is often associated with extra-intestinal manifestations (EIMs) and may occur before or after IBD diagnosis. Ocular manifestations are the third most common EIMs, with musculoskeletal and dermatologic being the first and second, respectively [2 ▪▪ ]. Other EIMs are renal, pulmonary, and endocrine involvement.…”

Section: Introductionmentioning

confidence: 99%

A review of ophthalmic manifestations of inflammatory bowel disease and associated treatments

Janardhana

Al-Kadhi

2021

Current Opinion in Ophthalmology

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Purpose of reviewTo review the ocular manifestations of inflammatory bowel disease (IBD) and the treatments for each of these, including novel therapies and their effects on uveitis. With the advent of newer treatments for ulcerative colitis and Crohn's disease, it is important to investigate whether these therapies have beneficial effects for extraintestinal manifestations (EIM) of IBD, in particular, ocular manifestations. Recent findingsThe newer treatments for IBD, including biologics, such as golimumab (Simponi), certolizumab (Cimzia), vedolizumab (Entyvio), and interleukin (IL) receptor inhibitors, such as ustekinimab (Stelara), could potentially have treatment benefits for patients with uveitis and IBD.

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“…Although the whole body can be involved, EIMs predominantly affect the skin, joints, biliary tract, and eyes ( 8 ). The prevalence of ocular manifestations in IBD range from 0.3 to 13%, based on the population studied, and they occur more frequently in patients with CD (3.5–6%) as compared with UC (1.6–4.6%) ( 7 , 9 , 10 ). The most frequent ocular manifestations observed in IBD patients are episcleritis, scleritis, and uveitis ( 8 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of ocular manifestations in IBD range from 0.3 to 13%, based on the population studied, and they occur more frequently in patients with CD (3.5-6%) as compared with UC (1.6-4.6%) (7,9,10). The most frequent ocular manifestations observed in IBD patients are episcleritis, scleritis, and uveitis (8,10). Among ophthalmic EIMs of IBD, some are potentially vision threatening with severe consequences if not treated properly (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Association Between Ischemic Optic Neuropathy and Inflammatory Bowel Disease: A Population-Based Cohort Study in Taiwan

et al. 2021

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Background: Ischemic optic neuropathy (ION) is a possible extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). We investigate the relation between IBD and ION and possible risk factors associated with their incidence.Methods: Medical records were extracted from the National Health Insurance Research Database (NHIRD) from January 1, 2000, to December 31, 2013. The main outcome was ION development. Univariate and multivariate Cox regression analyses were performed.Results: We enrolled 22,540 individuals (4,508 with IBD, 18,032 without). The cumulative risk of developing ION was significantly greater for patients with IBD vs. patients without (Kaplan–Meier survival curve, p = 0.009; log-rank test). Seven (5%) and five (0.03%) patients developed ION in the IBD and control groups, respectively. Patients with IBD were significantly more likely to develop ION than those without IBD [adjusted hazard ratio (HR) = 4.135; 95% confidence interval: 1.312–11.246, p = 0.01]. Possible risk factors of ION development were age 30–39 years, diabetes mellitus (DM), hypertension, ischemic heart disease (IHD), atherosclerosis, and higher Charlson comorbidity index revised (CCI_R) value.Conclusion: Patients with IBD are at increased risk of subsequent ION development. Moreover, for patients with comorbidities, the risk of ION development is significantly higher in those with IBD than in those without.

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Ocular manifestations of inflammatory bowel diseases: an update for gastroenterologists

Cited by 3 publications

References 69 publications

Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier

Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier

A review of ophthalmic manifestations of inflammatory bowel disease and associated treatments

Association Between Ischemic Optic Neuropathy and Inflammatory Bowel Disease: A Population-Based Cohort Study in Taiwan

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