Ocular manifestations of leukaemia: A teaching hospital experience

Ilo, Olubanke Theodora; Adenekan, Adetunji; Alabi, Adegboyega Sunday; Onakoya, Adeola O; Aribaba, Olufisayo Tade; Kehinde, MO; Salako, Omolola

doi:10.4103/npmj.npmj_50_19

Cited by 11 publications

(13 citation statements)

References 15 publications

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“…Retinal hemorrhage was the most commonly seen among the 23 manifestations, but it was not associated with a specific type of acute leukemia. Similar to this study, most studies have reported retinal hemorrhage as the most common ophthalmic manifestation in acute leukemia patients [4,5,[8][9][10].…”

Section: Discussionsupporting

confidence: 88%

“…Ophthalmic manifestations have been reported in the literature with different prevalence from study to study, ranging from 24% to 70% [4,[8][9][10][13][14][15][16][17]. Also, some studies that have been done in Saudi Arabia reported prevalence ranging from 35%-54%; however, these studies are old and published in the '90s [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…Ocular manifestations may be caused by the infiltration of circulating leukemic cells in the optic disc, uvea, retinal nerve fibers, and other intraocular tissues [7]. Some leukemia patients may have ocular involvement that could precede the systemic features of the disease [8]. According to different studies, retinal hemorrhage is the most common ophthalmic manifestation in leukemia patients [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Some leukemia patients may have ocular involvement that could precede the systemic features of the disease [8]. According to different studies, retinal hemorrhage is the most common ophthalmic manifestation in leukemia patients [7][8][9][10]. Acute leukemia patients are more prone to ophthalmic manifestations than chronic leukemia [11].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, ocular infiltration is the third most common extramedullary presentation of acute leukemia after the meninges and testicles [ 7 ]. Also, up to 90% of patients with leukemia could present with ocular manifestations during their disease [ 8 ]. Ocular manifestations may be caused by the infiltration of circulating leukemic cells in the optic disc, uvea, retinal nerve fibers, and other intraocular tissues [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Ophthalmic Manifestations in Acute Leukemia Patients and Their Relation With Hematological Parameters in a Tertiary Care Center

Bukhari¹,

Alzahrani²,

Alqarni³

et al. 2021

Cureus

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Background: Leukemia is a neoplastic disorder that affects blood and bone marrow and is characterized by white blood cells' abnormal proliferation. Leukemia patients may present with different ophthalmic manifestations. This study aims to provide an updated data about the prevalence and types of ocular manifestations in acute leukemia patients and their relation with the hematological parameters. Methods: This retrospective cross-sectional study included all acute leukemia patients diagnosed from 2015 to 2020 and underwent an ophthalmic examination during this period at King Abdulaziz Medical City in Jeddah. Results: Eighty-one patients met the inclusion and exclusion criteria and had ophthalmic examinations. Forty-three (53.1%) patients were males, and 38 (46.9%) patients were females. Acute lymphocytic leukemia (ALL) was diagnosed in 55 (67.9%) patients, while acute myelogenous leukemia (AML) was diagnosed only in 26 (32.1%). Ophthalmic manifestations were observed in 23 patients with a prevalence of 28.4%. AML patients had more manifestations with a rate of 38.5%. ALL had a rate of 23.6% (p=0.1). Retinal hemorrhage was the most commonly seen manifestation in six patients. Conclusion: Ophthalmic manifestations are not uncommon in acute leukemia patients. Low hemoglobin and RBC could give an idea about the type of ophthalmic manifestation, not the presence or absence. It is highly recommended to examine acute leukemia patients routinely prior, during, and after the treatment to prevent serious ocular damage and monitor the course of the disease.

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