Ocular melanomas and melanocytic lesions of the eye

Grin, Jennifer M.; Grant‐Kels, Jane M.; Grin, Caron M.; Berke, Adrienne; Kels, Barry D.

doi:10.1016/s0190-9622(98)70201-4

Cited by 48 publications

(46 citation statements)

References 56 publications

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“…Fifteen lesions (68.18%) involved the bulbar conjunctiva and seven lesions (31.81%) involved the palpebral conjunctiva. These data are in agreement with previous reports (8)(9)(10) .…”

Section: Discussionsupporting

confidence: 94%

“…In the present study, we report a male to female ratio of 1:1.2 (45.8% males and 54.17% females). The age of presentation of conjunctival melanoma is usually in the fifth decade and it is only exceptionally observed in patients under 20 years of age, data which are in agreement with our results, with only one patient presented being under 20 years old (9,10) . These tumors may arise de novo or from a pre-existing nevus, or more frequently from a PAM with proportions highly variable among different studies.…”

Section: Discussionsupporting

confidence: 92%

“…These tumors may arise de novo or from a pre-existing nevus, or more frequently from a PAM with proportions highly variable among different studies. Approximately 50% to 75% originate from areas of PAM, 4% to 26% from conjunctival nevi and 18% to 39% arise de novo (8)(9)(10)(11) . We found that 18 patients (75%) had a previous history of melanosis.…”

Section: Discussionmentioning

confidence: 99%

“…As well as other treatment modalities such as cryotherapy, surgical techniques for management of this tumor have evolved slowly, being performed mainly at oncology centers (9) . In conjunctival melanoma, relatively narrow margins are obtained to preserve visual func tion.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Conjunctival melanoma: survival analysis in twenty-two Mexican patients

Salcedo-Hernández¹,

Luna-Ortiz²,

Lino-Silva³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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“…Fifteen lesions (68.18%) involved the bulbar conjunctiva and seven lesions (31.81%) involved the palpebral conjunctiva. These data are in agreement with previous reports (8)(9)(10) .…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Conjunctival melanoma: survival analysis in twenty-two Mexican patients

Salcedo-Hernández¹,

Luna-Ortiz²,

Lino-Silva³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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“…Intracranial melanocytic non-metastatic tumors can be associated with nevus of Ota or oculodermal melanosis [4]; to the best of our knowledge, the association of melanocytic tumors with simple melanosis oculi [22] has not been reported: only one case of intracranial melanoma associated with melanosis oculi has been previously described [23]. The importance of this association cannot be overestimated for the clinical differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Intracranial melanocytic meningeal tumours and melanosis oculi: case report and literature review

Doglietto

Colosimo²,

Lauriola

et al. 2012

BMC Cancer

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BackgroundMelanocytic meningeal tumours are rare extra-axial neoplasms of the nervous system, with only three reported cases in the cavernous sinus. Herein we describe for the first time the association of ocular melanosis and multiple intracranial melanocytic meningeal tumours, with the presenting lesion being in the cavernous sinus. The importance of this association is discussed together with the diagnostic and therapeutic challenges of the case.Case presentationA 20-year-old man presented with a left sixth cranial nerve deficit; general examination documented only congenital melanosis of the homolateral eye. MRI examination showed a space occupying lesion in the left cavernous sinus, which was followed conservatively for 2 years, until a new space occupying lesion was evident at the level of the right frontal convexity: both lesions presented with neuroradiological characteristics suggestive of melanin content.The frontal convexity lesion was removed: intraoperatively the dura was markedly and diffusely melanotic. Histological examination documented a melanocytic meningeal tumour, with a proliferative index of 3 %. The patient underwent 3D-Conformal Radiation Therapy on the lesion of the cavernous sinus (total dose 5040 cGy), with initial tumour reduction. Three years later, due to a symptomatic growth, he underwent partial removal of the lesion in the cavernous sinus. Histological examination was unchanged. He then received adjuvant Temozolomide with Low Dose Fractionated Radiation Therapy (LD-FRT). Due to further disease progression cisplatin plus fotemustine were administered, concomitant with LD-FRT: after two cycles MRI documented significant disease regression. After a period of apparent disease control, the patient presented with persistent cough and evidence of multiple thoracic metastases, which lead to his death, seven years after presentation.ConclusionsIntracranial melanocytic meningeal tumours are challenging lesions, both from a diagnostic and therapeutic point of view; though rare, the possible association with ocular melanosis should be recognized and might facilitate an early diagnosis. Surgery remains the best possible option when feasible. In the event of partial resection, this “benign” disease might be clinically aggressive.

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Ocular Melanoma

Hurst¹

2003

Arch Dermatol

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Ocular melanomas and melanocytic lesions of the eye

Cited by 48 publications

References 56 publications

Conjunctival melanoma: survival analysis in twenty-two Mexican patients

Conjunctival melanoma: survival analysis in twenty-two Mexican patients

Intracranial melanocytic meningeal tumours and melanosis oculi: case report and literature review

Ocular Melanoma

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