Ocular Metastasis in Elderly Male Bladder Cancer Patients: Potential Risk Factors

Xu, Qianhui; Yuan, Qing; Zhang, Yuqing; Li, Biao; Min, You‐Lan; Ge, Qian‐Min; Liang, Rong‐Bin; Shao, Yi

doi:10.1177/1557988320908998

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…In contrast, serological tumor markers are widely used in clinical practice, due to their advantages of good reproducibility, low cost, and easy access. To date, a considerable number of researchers have proposed various serological markers related to disease metastasis and prognosis including intraocular metastasis from bladder cancer ; 28 however, there is a lack of specific SI for OM in older adult patients with GC. In our study, we collected serological data from 1165 patients with GC, including: HB, calcium, ALP, TC, TG, HDL, LDL, ApoA1, ApoB, AFP, CA724, CEA, CA199, CA125, CA153, CYFRA21 to 1, and Lp(a) and found that LDL, ApoA1, CA724, and CEA content differed significantly between the OM and NOM groups.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724

Shi

Sun

et al. 2022

Technol Cancer Res Treat

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Objective: The purpose of this study was to explore the risk factors for Ocular metastasis (OM) of Gastric cancer (GC). Methods: This is a retrospective cohort study. A total of 1165 patients with GC were enrolled in this study and divided into OM and non-ocular metastasis (NOM) groups. Chi-square and independent samples t tests were used to determine whether differences in demographic characteristics and serological indicators (SI) between the two groups were significant. In addition, binary logistic regression was used to analyze the value of various SI as risk factors for OM in patients with GC. The statistical threshold was set as P < .05. Finally, receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic value of various SI in differentiating the occurrence of OM in patients with GC. Results: The incidence of OM in older adults with GC was 1.1%. Adenocarcinoma was the most common type of GC in both groups, and there was no significant difference in demographic characteristics between the groups. Low-density lipoprotein (LDL), carbohydrate antigen-724 (CA724), and carcinoembryonic antigen levels were significantly higher in the OM group than the NOM group, while those of apolipoprotein A1 (ApoA1) were significantly lower in the OM than the NOM group. Binary logistic analysis showed that LDL, ApoA1, and CA724 were independent risk factors for OM in patients with GC ( P < .001, P = .033, and P = .008, respectively). ROC curve analysis generated area under the curve (AUC) values of 0.881, 0.576, and 0.906 for LDL, ApoA1, and CA724, respectively. In addition, combined analysis of LDL, ApoA1, and CA724 generated the highest AUC value of 0.924 ( P < .001). Conclusion: Among SI, LDL, ApoA1, and CA724 have predictive value for the occurrence of OM in GC, with the three factors combined having the highest value.

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Section: Discussionmentioning

confidence: 99%

Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724

Shi

Sun

et al. 2022

Technol Cancer Res Treat

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“…34,35 Therefore, in recent years, macromolecule materials have been used in the delivery of CpG ODN, including graphene oxidechitosan nanocomposites 36 and N-isopropylacrylamidemodified polyethyleneimine (PEN). 37 Previous studies demonstrated that the N-Ac-L-Leu-PEI/CpG ODN 2006 complex (w: w = 1: 1) was superior to microRNAs and single-stranded oligo DNAs (w: w = 2:1) 22,23,38 and to plasmid DNA (w:w = 0.6-0.8:1). 24 The PEN vehicle could completely retard ODN MT01 at a mass ratio of 0.5.…”

Section: Discussionmentioning

confidence: 99%

“…N-Ac-L-Leu-PEI significantly improved the biocompatibility and transfection efficiency, and significantly decreased protein adsorption and hemolytic activity of the PEI25K matrix. This vehicle has been successfully used to deliver the p53 gene, 21 a DNAzyme 22 and microRNA 23,24 to trigger the pronounced suppression of tumor cells and to upregulate bone formation in vivo and in vitro.…”

Section: Introductionmentioning

confidence: 99%

<p><em>N</em>-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis</p>

Wang

et al. 2020

DDDT

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Introduction: CpG oligodeoxynucleotides (CpG ODN) play important roles in resisting inflammation and bone resorption. However, the inherent instability and rapid degradation hinder their wider application. This study aimed to evaluate whether N-acetyl-L-leucinemodified polyethyleneimine (N-Ac-L-Leu-PEI) could effectively deliver CpG ODN 2006 to RAW264.7 cells and and if it can regulate osteoclastogenesis in vitro. Materials and Methods: Gel retardation assay was conducted to evaluate whether N-Ac-L-Leu-PEI and CpG ODN could form a stable complex. RAW264.7 cells were divided into four groups of control group, ODN group, phosphorothioate ODN group and N-Ac-L-Leu-PEI/ODN group. Fluorescence assay was conducted to evaluate the transfection rate of ODNs in different groups. Cell viability was determined by MTT assay. Cell apoptosis was determined by live-dead cell staining and flow cytometry assay. Relative expression levels of osteoclastic differentiation factors, including Nfatc, c-fos, receptor activator of nuclear factor κB (RANK), and matrix metalloproteinase 9 (MMP9), were determined by real-time PCR and Western blot. Results: N-Ac-L-Leu-PEI and CpG ODN could form a stable complex at a mass ratio of 1:1 (w:w). MTT assay showed that the cell viability of N-Ac-L-Leu-PEI was relatively high even at a mass ratio of 8 μg/mL. The transfection rate of N-Ac-L-Leu-PEI-ODN complex was higher than 90%. The cell proliferation and apoptosis was significantly enhanced in N-Ac-L-Leu-PEI-CpG ODN group when compared to those in phosphorothioate CpG ODN. The expression levels of Nfatc, c-fos, RANK, and MMP9 were significantly decreased in N-Ac-L-Leu-PEI/ODN complex group. Discussion: N-Ac-L-Leu-PEI could be a potential gene vehicle for the prevention of periodontitis-mediated bone resorption.

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Accuracy of Cytokeratin 19 Fragment in the Diagnosis of Bladder Cancer

et al. 2022

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Aim: CYFRA21-1 is a biomarker of cancer and has a promising future in the diagnosis of bladder cancer. The purpose of this study was to assess the diagnostic accuracy of CYFRA21-1 for bladder cancer. Methods: We included articles from the Cochrane Library, Web of Science, PubMed and Embase. Meta-DiSc 1.4 and Stata 12.0 were used for data analysis. Results: Twenty-eight articles were analyzed, and the results are as follows: sensitivity, specificity, PLR, NLR, DOR and AUC were 0.69 (95% CI [0.67, 0.71]), 0.81 (95% CI [0.80, 0.83]), 5.99 (95% CI [4.42, 8.11]), 0.31 (95% CI [0.25, 0.38]), 24.58 (95% CI [15.15, 39.89]) and 0.8917, respectively. Conclusion: CYFRA21-1 has a high diagnostic efficiency for bladder cancer.

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Ocular Metastasis in Elderly Male Bladder Cancer Patients: Potential Risk Factors

Cited by 3 publications

References 24 publications

Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724

Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724

<p><em>N</em>-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis</p>

Accuracy of Cytokeratin 19 Fragment in the Diagnosis of Bladder Cancer

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