Ocular Microtherapy

Richardson, Kenneth T.

doi:10.1001/archopht.1975.01010020078014

Cited by 18 publications

(2 citation statements)

References 53 publications

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“…The in vitro studies revealed an initially rapid release of the drug followed by a slower release. This is fully in agreement with the theoretical conception of a first order pattern of elimination (Richardson 1975). Using fluorescein as tracer, a similar initial rapid release from the lenses was found (Waltman & Kaufman 1970).…”

Section: Discussionsupporting

confidence: 88%

A Human and in Vitro Study on the Exchange of Water and Solutes From Soft Contact Lenses

Sørensen

Jensen

Marqversen

1980

Acta Ophthalmologica

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Elimination of technetium (pertechnetate in normal saline solution) was studied from various types of contact lenses placed on normal human eyes by means of computer assisted gamma camera using "region of interest technique" with the designated area corresponding to the conjunctival sac. An elimination 4 times slower was found from a highly hydrophilic lens (Scanlens) than from a HEMA-lens (Softlens), 0,5% min and 2.0% min, respectively. From an ultrathin lens (U3-Softlens) was eliminated 2.4% min. Hard lenses did not absorb the isotope. In a laboratory study the lenses were pre-soaked in pertechnetate, blotted and washed at 2 min intervals in 0.5 ml saline. By this procedure 3% min of the technetium was eliminated from Scanlens, 16% min from Softlens and 28%/min from a thin, therapeutic lens (Plano-T). The ratio Softlens/Scanlens was in the human study 4.0 and in the laboratory study 4.9. Radioactivity was very rapidly eliminated from CAB-lenses. A similar study was carried out with radioactive water. More than 100% min was eliminated in the first 10 min followed by a slower elimination from 10-20 min. Then an increased elimination was seen for a few min. This increased elimination was in repeated studies constantly found after 20 min. It was not found in the studies with technetium and labelled leucine.

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Section: Discussionsupporting

confidence: 88%

A Human and in Vitro Study on the Exchange of Water and Solutes From Soft Contact Lenses

Sørensen

Jensen

Marqversen

1980

Acta Ophthalmologica

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“…A variety of solid delivery systems, responding totally or partially to the above requisites, have been developed in recent years. Medicated contact lenses, polymeric monolithic inserts and complex, zero-order diffusional systems may be mentioned as examples (Richardson 1975).…”

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confidence: 99%

Vehicle effects in ophthalmic bioavailability: An evaluation of polymeric inserts containing pilocarpine

Saettone

Giannaccini

Chetoni

et al. 1984

Journal of Pharmacy and Pharmacology

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A series of polymeric ophthalmic inserts containing pilocarpine were formulated with four different types of polyvinyl alcohol, PVA, and two types of hydroxypropylcellulose. Pilocarpine was present as the nitrate, or as the salt with polyacrylic acid, PAA. In-vivo miosis vs time experiments on albino rabbits, showed that all inserts increased significantly the bioavailability of pilocarpine, with respect to a standard solution of pilocarpine nitrate. Two PVA inserts, containing the PAA-salt of pilocarpine, were particularly effective. The preparations were also submitted to in-vitro release tests and to differential scanning calorimetry, to ascertain the release mechanism, and to verify, via the thermal behaviour, possible interactions between drug and polymers. The chemical and physiochemical factors, most likely to influence the ophthalmic bioavailability of pilocarpine from the present preparations, are briefly reviewed.

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Intermittent vs Continuous Steroid Administration

Keller¹

1976

Arch Ophthalmol

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Ocular Microtherapy

Cited by 18 publications

References 53 publications

A Human and in Vitro Study on the Exchange of Water and Solutes From Soft Contact Lenses

A Human and in Vitro Study on the Exchange of Water and Solutes From Soft Contact Lenses

Vehicle effects in ophthalmic bioavailability: An evaluation of polymeric inserts containing pilocarpine

Intermittent vs Continuous Steroid Administration

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