Ocular MRI Findings in Patients with Severe COVID-19: A Retrospective Multicenter Observational Study

The first year of the coronavirus disease 2019 (COVID-19) pandemic has been a year of unprecedented changes, scientific breakthroughs, and controversies. The radiology community has not been spared from the challenges imposed on global healthcare systems. Radiology has played a crucial part in tackling this pandemic, either by demonstrating the manifestations of the virus and guiding patient management, or by safely handling the patients and mitigating transmission within the hospital. Major modifications involving all aspects of daily radiology practice have occurred as a result of the pandemic, including workflow alterations, volume reductions, and strict infection control strategies. Despite the ongoing challenges, considerable knowledge has been gained that will guide future innovations. The aim of this review is to provide the latest evidence on the role of imaging in the diagnosis of the multifaceted manifestations of COVID-19, and to discuss the implications of the pandemic on radiology departments globally, including infection control strategies and delays in cancer screening. Lastly, the promising contribution of artificial intelligence in the COVID-19 pandemic is explored.

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“…No correlate was identified on fundoscopy or optical coherence tomography. The nature of these nodules remains unclear[ 154 ].…”

Section: Extrapulmonary Manifestationsmentioning

confidence: 99%

Imaging in the COVID-19 era: Lessons learned during a pandemic

Sidéris

Nikolakea²,

Karanikola³

et al. 2021

WJR

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“…The analysis of ocular (i.e. eyeball) structures have already been reported in a previous publication 24 . Therefore, they were not analyzed for this study.…”

Section: Methodsmentioning

confidence: 97%

“…These findings are relatively rare among COVID-19-infected patients, ranging from 2 to 32% 14 , 15 , 16 , 17 , 18 . Only a few MRI studies reported orbital and/or visual pathways abnormalities in patients with severe COVID-19 19 , 20 , 21 , 22 , 23 , 24 . Among them, the French Society of Neuroradiology (SFNR) reported ocular (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Abnormal MRI findings of the orbital or visual pathways in patients with severe COVID-19: Observations from the French multicenter COVID-19 cohort

Cotton

Lersy²,

Kremer³

et al. 2021

Journal of Neuroradiology

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Objectives COVID-19 is a multisystemic disease. Ophthalmological abnormalities are relatively rare among COVID-19-infected patients. The aim of our study was to report orbital and visual pathways MRI findings in a nationwide multicenter cohort of patients with severe COVID-19. Methods This IRB-approved retrospective multi-center study included participants presenting with severe COVID-19, who underwent brain MRI from March 4 th to May 1 st 2020. Two neuroradiologists (“blinded”), blinded to all data, individually analyzed morphological MRIs focusing on the orbits and the visual pathways. A second consensus reading session was performed in the case of disagreement between both readers. Clinical and ophthalmological data were compared to MRI findings. Descriptive statistical analysis and interobserver agreement for MRI reading using non-weighted Cohen kappa statistics were performed. Results 129 participants (43 [33%] women and 86 [67%] men, mean age 63 ± 14 years) were included in the study. 17/129 (13%) patients had abnormal MRI findings of the orbit or visual pathways. 11/17 (65%) patients had a FLAIR-WI hyperintense optic disc. 6/17 (35%) patients had abnormal signal of at least one of the visual pathway structures: 6/6 (100%) of the optic nerve, 1/6 (17%) of the optic chiasm, 2/6 (33%) of the optic tract and 1/6 (17%) of the optic radiations. Conclusions Our study showed that a substantial number of patients with severe COVID-19 presented with abnormal MRI findings of the orbit or visual pathways, which might lead to potentially severe visual impairment.

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“…Има и редица съобщения за по-сериозни заплашващи зрението усложнения като преден увеит, ретинални съдови оклузии, остра макулна невроретинопатия, остра ретинална некроза, заден и панувеит. Интерес представляват очните находки от проведен ядрено-магнитен резонанс при пациенти с тежко протичане на COVID-19, които показват най-често двустранни нодули в задния очен сегмент [4]. Проучване на Сим и сътр.…”

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Ocular Manifestations In COVID-19: Clinical Case Reports And A Literature (Review)

Oscar

Zdravkov

Hristova

et al. 2021

Bulgarian Review of Ophthalmology

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След откриването му през декември 2019 г., причиняващият тежък остър респираторен синдром коронавирус 2 (SARS-CoV-2) се превърна в глобална пандемия, засягаща над 130 милиона души от началото на епидемията до април 2021 [1]. SARS-CoV-2 може да засегне различни органи и клетъчни типове, като все още се събират данни за патофизиологията и клиничната картина.Въз основа на проучвания върху животински модели се предполага, че патофизиологията на коронавирусната инфекция се състои от две фази -първична инфекция с активна вирусна репликация и бърз имунен отговор и вторична фаза, вероятно свързана с автоимунни процеси [2].Най-честата очна проява при пациенти с остра SARS-CoV-2 инфекция е конюнктивитът [3].

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Ocular MRI Findings in Patients with Severe COVID-19: A Retrospective Multicenter Observational Study

Cited by 21 publications

References 23 publications

Imaging in the COVID-19 era: Lessons learned during a pandemic

Imaging in the COVID-19 era: Lessons learned during a pandemic

Abnormal MRI findings of the orbital or visual pathways in patients with severe COVID-19: Observations from the French multicenter COVID-19 cohort

Ocular Manifestations In COVID-19: Clinical Case Reports And A Literature (Review)

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