Ocular Pathogenicity of Types 1 and 2
            <i>Herpesvirus hominis</i>
            in Rabbits

Oh, Jang O.; Moschini, Giovanni B.; Okumoto, Masao; Stevens, Thomas R.

doi:10.1128/iai.5.3.412-413.1972

Cited by 13 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All but two (PH and MS) were recent isolates; PH and MS were laboratory strains with long histories of passages in various tissues. Their sources were all described in a previous paper (23). Before using them, we passed them once or twice in primary cultures of rabbit kidney cells grown in a medium consisting of 95% medium 199, 5% rabbit serum, and antibiotics (21).…”

Section: Methodsmentioning

confidence: 99%

Different susceptibilities of skin to type 1 and type 2 herpes simplex viruses in newborn rabbits

Oh¹,

Minasi²

1980

Infect Immun

View full text Add to dashboard Cite

Skin infections with type 1 herpes simplex virus (HSV-1) were compared with skin infections with type 2 virus (HSV-2). Five strains each of HSV-1 and HSV-2 were tested by injecting 103 50% tissue culture infective doses of each strain subcutaneously into 1-day-old New Zealand white rabbits. All five strains of HSV-2 produced severe skin lesions that resulted in wide dissemination of the infection to many organs, paralysis of the hind legs, and finally death. The virus could be isolated frequently from skin lesions, from various organs (liver, lungs, adrenal glands, brain, and eyes), and from circulating leukocytes and plasma. In contrast, all five strains of HSV-1 failed to produce significant skin lesions or dissemination of virus, only half of the skin lesions yielded HSV, and no virus could be isolated from the blood. These results indicate that HSV-1 does not grow well in the skin of newborn rabbits and fails to disseminate, whereas HSV-2 is dermatotropic and disseminates readily to many organs by hematogenous routes. Ever since Batignani (2) reported the first case of neonatal infection with herpes simplex virus (HSV) in 1934, neonatal HSV infection has been recognized with increasing frequency. Over 90% of isolates recovered from infections of newborns (usually derived from infected mothers) are type 2 HSV (HSV-2) (16). When neonates acquire herpes infection from the maternal genital tract, either in utero after its ascent from the cervix or during the course of delivery, the skin, eye, and ororespiratory ori

show abstract

Section: Methodsmentioning

confidence: 99%