Ocular Pharmacokinetics and Pharmacodynamics in Rabbits of Ibopamine, a New Mydriatic Agent

Intracameral Mydriatics in Cataract Surgery

“…Interestingly, epinine was significantly more potent than phenylephrine at equal concentrations. Similar results have also been demonstrated for related topical substances: ibopamine, an ester of epinine, is hydrolyzed to epinine during its passage through the cornea and exerts its pharmacological effects within the eye as epinine (Soldati, Gianesello et al 1993). Topical ibopamine is routinely used as a mydriatic in some countries due to its interesting pharmacological profile: 2% ibopamine is a more potent mydriatic than 10% phenylephrine (Marchini, Babighian et al 2003), and the mydriatic effect is reversed within 4 hours (Gelmi, Palazzuolo et al 1989), making ibopamine the most short-acting and most effective topical mydriatic agent studied this far.…”

Ibopamine – A New Alpha-Adrenergic and D1-Dopaminergic Drug

“…This hydrolysis suggests that epinine is the active component of the molecule. The half-life of ibopamine in the aqueous humor is short (about 2 minutes) and epinine formation precedes the mydriatic effect [3,4] (Figure 1). It has been proved that after the instillation of ibopamine, only epinine can be found in the aqueous humor [3].…”

Ibopamine

“…The very high rate of ibopamine's hydrolyzation to epinine suggests the latter being the active component of the molecule. 9 Ibopamine's half-life in the aqueous humor is very short (1.9 minutes) and epinine's formation precedes its mydriatic effect. It has been documented that, after instillation of ibopamine, only epinine is found in the aqueous humor.…”