Ocular Photodynamic Therapy in Choroidal Neovascularization Complicating Idiopathic Central Serous Chorioretinopathy

Canakis, Christina; Conway, Mandi D.; Livir-Rallatos, Charalampos; Naaman, Georges; Ratnakaram, R.; Men, Gamze; Peyman, Gholam A.

doi:10.3928/1542-8877-20040301-17

Cited by 11 publications

(5 citation statements)

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“…Resolution of serous detachment followed treatment in the majority of patients, as did visual improvement. No complications have been reported (Canakis et al. 2003, 2004; Cardillo et al.…”

Section: Treatmentmentioning

confidence: 99%

Central serous chorioretinopathy

Wang

Munch

Hasler

et al. 2008

Acta Ophthalmologica

587

521

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ABSTRACT.Central serous chorioretinopathy (CSC) is a disease of the retina characterized by serous detachment of the neurosensory retina secondary to one or more focal lesions of the retinal pigment epithelium (RPE). CSC occurs most frequently in mid-life and more often in men than in women. Major symptoms are blurred vision, usually in one eye only and perceived typically by the patient as a dark spot in the centre of the visual field with associated micropsia and metamorphopsia. Normal vision often recurs spontaneously within a few months. The condition can be precipitated by psychosocial stress and hypercortisolism. Ophthalmoscopic signs of CSC range from mono-or paucifocal RPE lesions with prominent elevation of the neurosensory retina by clear fluid -typical of cases of recent onset -to shallow detachments overlying large patches of irregularly depigmented RPE. The spectrum of lesions includes RPE detachments. Granular or fibrinous material may accumulate in the subretinal cavity. Serous detachment often resolves spontaneously. From first contact, counselling about the potential relation to stress and glucocorticoid medication is warranted. After 3 months without resolution of acute CSC or in chronic CSC, treatment should be considered. Resolution of detachment can usually be achieved in acute CSC by focal photocoagulation of leaking RPE lesions or, in chronic CSC, by photodynamic therapy. The effect of therapy on long-term visual outcome is insufficiently documented. Reattachment within 4 months of onset is considered a relevant therapeutic target because prolonged detachment is associated with photoreceptor atrophy. This suggests that the value of treatment depends upon proper selection of cases that will not resolve without therapy. Chronic CSC may be difficult to differentiate from occult choroidal neovascularization secondary to CSC. Patients with chronic CSC who receive glucocorticoid treatment for systemic disease can often be managed without having to discontinue this medication.

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“…Resolution of serous detachment followed treatment in the majority of patients, as did visual improvement. No complications have been reported (Canakis et al. 2003, 2004; Cardillo et al.…”

Section: Treatmentmentioning

confidence: 99%

Central serous chorioretinopathy

Wang

Munch

Hasler

et al. 2008

Acta Ophthalmologica

587

521

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“…8,11,12,15 Occult (subretinal pigment epithelium [RPE], Type 1 neovascularization) CNV secondary to CSC has rarely been described before. 4,7 In this report, we describe the clinical and multimodal imaging features of patients with Type 1 neovascularization that we believe occurred secondary to long-standing CSC.…”

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confidence: 95%

“…Spaide et al 4 examined a consecutive series of 130 patients with CSC over an 18-month period and detected 12 patients (9%) who had CNV. Other studies have focused on treatment of a few patients with CNV secondary to CSC treated with intravitreal anti-vascular endothelial growth factor (VEGF), 5,6 photodynamic therapy (PDT), [7][8][9][10][11] or submacular surgery. 12 Not all studies found an association.…”

mentioning

confidence: 99%

Type 1 (Sub-Retinal Pigment Epithelial) Neovascularization in Central Serous Chorioretinopathy Masquerading as Neovascular Age-Related Macular Degeneration

Fung

Yannuzzi

Freund

2012

Retina

220

155

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Some patients presenting with Type 1 neovascularization may have clinical and multimodal imaging findings more consistent with long-standing CSC than with age-related macular degeneration. These patients are more likely to be younger, men, have thicker choroids, and have a higher prevalence of polypoidal neovasculopathy than those patients with Type 1 neovascularization secondary to age-related macular degeneration. Proper identification of these patients may have implications for their natural course and management.

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“…1,2,5,6 Chronic CSC may predispose to the development of choroidal neovascularization (CNV). [7][8][9][10][11][12][13][14][15][16][17] The prevalence of CNV in chronic CSC cases has been estimated by different authors to be around 4% to 8%. 1,8,9 Long-standing CSC can show subtle signs that may suggest the presence of an occult CNV such as an indistinct late leakage on fluorescein angiography (FA) or the presence of fibrin or lipid deposition, as well as the presence of PED.…”

mentioning

confidence: 99%