Ocular presentation of natural killer/T-cell lymphoma in a Caucasian man

Abstract

Natural killer/T-cell (NK/T-cell) lymphoma—nasal subtype, is a rare form of non-Hodgkin's lymphoma, most common in South East Asia, and can have an ophthalmological presentation. This report describes a 51-year-old Caucasian man with uveitis, recurrent retinal detachment and paraneoplastic features subsequently diagnosed as NK/T-cell lymphoma.

Simultaneous intraocular and cutaneous extranodal NK/T cell lymphoma refractory to multiple therapies including pembrolizumab

“…Uveitis was the primary finding in all cases of previously described ocular ENKL, with or without retinal/choroidal detachments. [16][17][18][19][20][21][22] In the current case, the patient presented with recurrent uveitis and vitreous hypercellularity, with no other cause found. True CNS ENKL is extremely rare and the optimal therapy is unknown.…”

Nasal-type extranodal NK/T-cell lymphoma presenting as recurrent periorbital cellulitis

“…This is not the first Irish case of ENKTCL causing orbital complications. Hughes et al describes uveitis and recurrent retinal detachment 10…”

Simultaneous intraocular and cutaneous extranodal NK/T‐cell lymphoma refractory to multiple therapies including pembrolizumab

“…ENKL with ocular involvement is extremely rare, and only four biopsy‐proven case reports were identified in the medical literature 16‐19 . There have been other cases described which likely represent ocular involvement, without histological evidence 20,21 . All cases described have occurred in patients with nasal ENKL as opposed to extranasal.…”

“…[16][17][18][19] There have been other cases described which likely represent ocular involvement, without histological evidence. 20,21 All cases described have occurred in patients with nasal ENKL as opposed to extranasal. Uveitis was the primary finding in all cases of previously described ocular ENKL, with or without retinal/choroidal detachments.…”