Ocular Response of Choroidal Melanoma With Monosomy 3 Versus Disomy 3 After Iodine-125 Brachytherapy

Marathe, Omkar; Wu, Jang‐Yen; Lee, Steve P.; Yu, Fei; Burgess, Barry L.; Leu, Min Y.; Straatsma, Bradley R.; McCannel, Tara A.

doi:10.1016/j.ijrobp.2010.07.016

Cited by 18 publications

(13 citation statements)

References 9 publications

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“…Moreover, the location (ciliary vs. choroidal) or initial height of the tumor also had no statistical correlation with the regression rates following radiation therapy. Our results are in agreement with some of the previously reported studies [19,21,23]. …”

Section: Discussionsupporting

confidence: 94%

“…Rapid regression was either noticed in a study limited to ciliochoroidal melanoma [21] or in a study that included tumors treated with transpupillary thermotherapy in addition to brachytherapy [20]. Chiam et al [22] reported absence of correlation between the rate of regression following radiation therapy and chromosome 3 status in a larger study (149 cases), supporting our observation.…”

Section: Discussionsupporting

confidence: 85%

“…Prior correlative studies that have assessed the rate of regression of a tumor and its chromosome 3 status have reported conflicting results [20,21,22]. Rapid regression was either noticed in a study limited to ciliochoroidal melanoma [21] or in a study that included tumors treated with transpupillary thermotherapy in addition to brachytherapy [20].…”

Section: Discussionmentioning

confidence: 99%

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Uveal Melanoma Regression after Brachytherapy: Relationship with Chromosome 3 Monosomy Status

et al. 2016

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Aim: The objective was to evaluate the relationship between the regression rate of ciliary body melanoma and choroidal melanoma after brachytherapy and chromosome 3 monosomy status. Methods: We conducted a prospective and consecutive case series of patients who underwent biopsy and brachytherapy for ciliary/choroidal melanoma. Tumor biopsy performed at the time of radiation plaque placement was analyzed with fluorescence in situ hybridization to determine the percentage of tumor cells with chromosome 3 monosomy. The regression rate was calculated as the percent change in tumor height at months 3, 6, and 12. The relationship between regression rate and tumor location, initial tumor height, and chromosome 3 monosomy (percentage) was assessed by univariate linear regression (R version 3.1.0). Results: Of the 75 patients included in the study, 8 had ciliary body melanoma, and 67 were choroidal melanomas. The mean tumor height at the time of diagnosis was 5.2 mm (range: 1.90-13.00). The percentage composition of chromosome 3 monosomy ranged from 0-20% (n = 35) to 81-100% (n = 40). The regression of tumor height at months 3, 6, and 12 did not statistically correlate with tumor location (ciliary or choroidal), initial tumor height, or chromosome 3 monosomy (percentage). Conclusion: The regression rate of choroidal melanoma following brachytherapy did not correlate with chromosome 3 monosomy status.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Uveal Melanoma Regression after Brachytherapy: Relationship with Chromosome 3 Monosomy Status

et al. 2016

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“…Recently, Marathe et al 9 reported that the reduction in thickness 2 years after iodine brachytherapy is more than double in monosomy 3 tumours in comparison with disomy 3 tumours.…”

Section: Discussionmentioning

confidence: 99%

“…Complete loss of chromosome 3 (ie, ‘monosomy 3’) is strongly associated with higher incidence of metastatic death 5–8. Another study comparing the tumour size 2 years after iodine-125 radiotherapy showed that regression of monosomy 3 choroidal melanomas was greater than of disomy 3 tumours 9. These studies suggest that the rate of tumour regression may be an important indicator for metastatic spread.…”

Section: Introductionmentioning

confidence: 94%

Does choroidal melanoma regression correlate with chromosome 3 loss after ruthenium brachytherapy?

et al. 2014

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Tumor-height regression rate after brachytherapy between choroidal melanoma gene expression profile classes: effect of controlling for tumor height

Gupta

McCannel

Kamrava

et al. 2016

Graefes Arch Clin Exp Ophthalmol

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Ocular Response of Choroidal Melanoma With Monosomy 3 Versus Disomy 3 After Iodine-125 Brachytherapy

Cited by 18 publications

References 9 publications

Uveal Melanoma Regression after Brachytherapy: Relationship with Chromosome 3 Monosomy Status

Uveal Melanoma Regression after Brachytherapy: Relationship with Chromosome 3 Monosomy Status

Does choroidal melanoma regression correlate with chromosome 3 loss after ruthenium brachytherapy?

Tumor-height regression rate after brachytherapy between choroidal melanoma gene expression profile classes: effect of controlling for tumor height

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