Ocular Sarcoidosis

Patel, Sarju

doi:10.1097/iio.0000000000000069

Cited by 10 publications

(9 citation statements)

References 31 publications

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“…The underlying etiology of sarcoidosis is still unknown. The reported incidence of sarcoidosis ranges from 2 to 107 cases per 100,000 people in different races [3,5,6] . Formation of epithelioid granulomas is the characteristic feature of sarcoidosis [1,2,7] …”

Section: Introductionmentioning

confidence: 99%

“…[3,8] Uveitis, the sight threatening complication, can be diagnosed up to 20% to 30% of patients during the course of the disease. [3,8] Intraocular findings suggestive for the diagnosis of ocular sarcoidosis include conjunctival nodules, keratic precipitates, episcleritis, iris nodules, peripheral anterior synechiae, vitreous opacities, choroidal granulomas, retinal vasculitis, and optic disc nodules. [8][9][10] The choroid consists of a network of capillaries and larger choroidal vessels.…”

Section: Introductionmentioning

confidence: 99%

“…[8] Ocular and peri-ocular manifestations are seen in approximately 25% to 83% of patients with sarcoidosis. [3,4] All ocular structures, mostly uvea and lacrimal system, may be affected in sarcoidosis. [3,8] Uveitis, the sight threatening complication, can be diagnosed up to 20% to 30% of patients during the course of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Choroidal vascularity index and thickness in sarcoidosis

et al. 2022

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Sarcoidosis is a multisystem granulomatous disease which is observed worldwide. Sarcoidosis is one of the common causes of ocular inflammation. The choroidal vascularity index, defined as the ratio of the luminal area to the total choroidal area, is used as one of the biomarkers for assessing the choroid vascular state. We aimed to compare choroidal vascularity index and thickness measurements between sarcoidosis patients and healthy controls.Thirty-one patients with sarcoidosis and 31 age-gender matched healthy participants were recruited in this cross-sectional and comparative study. Choroidal vascularity index was defined as the ratio of luminal area to total choroidal area after binarization on optical coherence tomography images. Anterior segment examinations included central corneal thickness, corneal volume, anterior chamber depth, anterior chamber volume, and iridocorneal angle. Spectral-domain optical coherence tomography was used to measure peripapillary retinal nerve fiber layer thickness, choroidal thickness, and retinal vessel caliber.The mean choroidal vascularity index value was 61.6% in sarcoidosis patients and 62.4% in healthy controls (P = .69). The choroidal vascularity index and thickness were significantly correlated in both sarcoidosis (r = 0.41, P = .026) and control groups (r = 0.51, P = .006). Both the sarcoidosis and control groups had similar measured values for central corneal thickness, corneal volume, anterior chamber depth, anterior chamber volume, and iridocorneal angle (P > .05). Mean retinal nerve fiber layer, retinal arteriole and venule caliber, and choroidal thickness measurements did not differ significantly between the groups (P > .05).Sarcoidosis patients in quiescent period have similar choroidal vascularity index and thickness with healthy controls.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Choroidal vascularity index and thickness in sarcoidosis

et al. 2022

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“…Sarcoidosis is a multiorgan disorder characterized by noncaseating epithelioid granulomas that may affect virtually any organ system. The cause of sarcoidosis remains unknown, but the underlying immunopathogenesis is being explored (1). The organs most commonly involved are the lungs, skin, lymph nodes, and eye.…”

Section: Introductionmentioning

confidence: 99%

“…Common complications of ocular sarcoidosis include cystoid macular edema, retinal vasculitis with segmental periphlebitis, and retinal vascular occlusion; choroidal neovascularization (CNV) occurs rarely in patients with sarcoidosis, but can be vision-threatening when it involves peripapillary locations (1, 3).…”

Section: Introductionmentioning

confidence: 99%