Ocular Side Effects of Bisphosphonates: A Review of Literature

Chartrand, Nicholas A; Lau, Chap-Kay; Parsons, Mark T; Handlon, Jaiden J; Ronquillo, Yasmyne C; Hoopes, Phillip C; Moshirfar, Majid

doi:10.1089/jop.2022.0094

Cited by 15 publications

(20 citation statements)

References 137 publications

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“…The ocular inflammatory response induced by bisphosphonates has been well described [38 ▪ ], with the most common manifestations presenting as uveitis, episcleritis, scleritis, orbital inflammation, and/or conjunctivitis. Recent studies have postulated immune-mediated mechanisms for these presentations due to M1 macrophage activation, γδ T-cell proliferation, and immune-complex deposition driving inflammatory responses [39,40].…”

Section: Examples Of the Role Of Innate Immune Responses In Immune Me...mentioning

confidence: 99%

“…For more serious reactions, such as scleritis and orbital inflammation, systemic corticosteroids are given. Cycloplegics are indicated for anterior uveitis [38 ▪ ]. There are conflicting data on rechallenge with the same bisphosphonate; some reports indicate recurrence of symptoms while others do not [45,46].…”

Section: Examples Of the Role Of Innate Immune Responses In Immune Me...mentioning

confidence: 99%

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Ocular involvement in allergic drug reactions

Fernandez

Phillips

Saeed

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Many systemic medications have been observed to cause ocular toxicity. A subset of these reactions is thought to involve immunomodulation or a hypersensitivity reaction. As new medications are developed, ocular adverse effects are becoming increasingly prevalent. Herein we review immune-mediated drug reactions affecting they eye with special attention to the hypersensitivity mechanisms leading to ocular toxicity. Recent findings Recent work has focused on mechanisms and risk of immune-mediated ocular adverse drug reactions including genetic susceptibility and loss of ocular immune privilege. Summary Given the consequences of immune-mediated ocular adverse drug reactions, clinicians must be aware of these to facilitate early recognition and management. The prompt involvement of an ophthalmologist for diagnosis and management is often essential to preserve vision and avoid long-term morbidity.

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Section: Examples Of the Role Of Innate Immune Responses In Immune Me...mentioning

confidence: 99%

Section: Examples Of the Role Of Innate Immune Responses In Immune Me...mentioning

confidence: 99%

Ocular involvement in allergic drug reactions

Fernandez

Phillips

Saeed

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Afferent and efferent visual manifestations of autoimmune diseases often share phenotypic features with common ischemic, infectious, and neoplastic neuro-ophthalmic syndromes. For this reason, carefully exploring the onset of the problem, clinical course, provoking or alleviating factors, comorbidities (particularly preestablished autoimmune diseases or cancers), associated symptoms, family history, and medication exposures may help identify an underlying autoimmune process (Table 1) [6][7][8][9][10][11][12][13][14]. Once the clinical localization and differential diagnosis are determined by history, suspected autoimmune mechanisms of a neuroophthalmic syndrome may be identified with a thorough examination.…”

Section: Localizing the Diagnosis: Clinical-anatomical Correlationmentioning

confidence: 99%

Neuro-ophthalmic manifestations of autoimmune disorders: diagnostic pearls & pitfalls

Poonja,

Costello

2023

Current Opinion in Ophthalmology

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Purpose of review The purpose of this review is to highlight a clinical-anatomical approach to localizing neuro-ophthalmic manifestations of associated autoimmune disorders. Recent findings Our understanding of autoimmune conditions has changed considerably over recent years, particularly with the emergence of novel autoantibodies. Cardinal neuro-ophthalmic signs and symptoms of antibody-mediated autoimmune disorders have been well characterized; knowledge thereof may be the first step towards an accurate diagnosis. Summary A thorough history, further refined by a comprehensive examination are cornerstones to disease localization in clinical medicine. Taken together, these essential steps both guide investigations and facilitate early recognition of autoimmune disorders. From a neuro-ophthalmic perspective, it is important to understand heralding signs and symptoms of autoimmune syndromes, avoid cognitive errors, and remain mindful of common diagnostic pitfalls to optimize care. Video abstract http://links.lww.com/COOP/A61

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“…A recent review has identified 101 reports of bisphosphonate-associated ocular inflammations such as uveitis, scleritis, episcleritis, orbital inflammation, and/or conjunctivitis [1]. In view of the widespread use of these medications to treat osteoporosis, it is important to alert ophthalmologists to these rare ocular manifestations.…”

Section: Introductionmentioning

confidence: 99%

Scleritis and Intraorbital Inflammation following Oral and Intravenous Bisphosphonates in a 66-Year-Old Man

Heck,

Malinina,

Palmowski

2024

Klin Monbl Augenheilkd

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Ocular Side Effects of Bisphosphonates: A Review of Literature

Cited by 15 publications

References 137 publications

Ocular involvement in allergic drug reactions

Ocular involvement in allergic drug reactions

Neuro-ophthalmic manifestations of autoimmune disorders: diagnostic pearls & pitfalls

Scleritis and Intraorbital Inflammation following Oral and Intravenous Bisphosphonates in a 66-Year-Old Man

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