Ocular Side Effects of Systemic Drugs

Garg, Pragati; Yadav, Swati

doi:10.24041/ejmr2019.111

Cited by 3 publications

(2 citation statements)

References 68 publications

(30 reference statements)

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“…Ocular side effects of some antihypertensive drugs include dry eye and its related conditions. 42 It is therefore possible that the use of these medications could contribute to the high prevalence of DED and MGD in the present study. These limitations notwithstanding, this study reports for the first time the prevalence of DED and MGD among patients with diabetes in Ghana and that ocular surface epithelial damage is the strongest predictor of MGD in these patients.…”

Section: Limitationmentioning

confidence: 84%

Dry eye disease and meibomian gland dysfunction among a clinical sample of type 2 diabetes patients in Ghana

Abu¹,

Ofori²,

Boadi-Kusi³

et al. 2022

Afr H. Sci.

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Objective: To evaluate dry eye disease and meibomian gland dysfunction among type 2 diabetes patients Methods: A hospital-based cross-sectional study was conducted. Parameters assessed included meibum expressibility and quality, Schirmer test 1, tear breakup time (TBUT), ocular surface staining, blink rates and Ocular Surface Disease Index (OSDI) scores. Dry eye was diagnosed based on a combination of subjective symptoms, tear function and ocular surface staining. Results: Prevalence of DED and MGD were 72.3% and 55.3% respectively. Symptomatic dry eye (OSDI scores) was significantly associated with duration of diabetes (rs = 0.11, P = 0.028) and the presence of conjunctival disorders (OR = 2.09, P = 0.002). MGD was a risk factor for DED (OR = 1.99, P = 0.008); ocular surface damage, the presence of eye lid lesions, abnormal Schirmer test and reduced TBUT were significantly associated with MGD, the strongest predictor being ocular surface damage (OR = 3.21, P = 0.001). OSDI scores had no association with the presence of corneal lesions possibly due to reduced corneal sensitivity. Conclusion: DED and MGD were prevalent among the patients and therefore there is the need for dry eye assessment as a routine clinical management protocol for patients with type 2 diabetes. Keywords: Dry eye disease; meibomian gland dysfunction; type 2 diabetes; Ghana.

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Section: Limitationmentioning

confidence: 84%

Dry eye disease and meibomian gland dysfunction among a clinical sample of type 2 diabetes patients in Ghana

Abu¹,

Ofori²,

Boadi-Kusi³

et al. 2022

Afr H. Sci.

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“…Anticoagulants can cause subconjunctival and retinal hemorrhages. Cardiac glycosides may also cause conjunctivitis (apart from blurred vision, xantopsia, pupillary disorders, nystagmus, photophopia, and toxic damage to the optic nerve), and rifampicin-conjunctival hyperemia [43,44]. These symptoms were taken into account as signs of ocular complications in this study.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Eye Complications in Patients Treated in the Intensive Care Unit

Płaszewska‐Żywko

Sega

Bukowa

et al. 2021

IJERPH

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In critically ill patients, normal eye protection mechanisms, such as tear production, blinking, and keeping the eye closed, are impaired. In addition, many other factors related to patients’ severe condition and treatment contribute to ocular surface disease. Reducing risk factors and proper eye care can have a significant impact on incidences of eye complications and patient quality of life after discharge from the intensive care unit (ICU). The aim of the study was to determine risk factors for ocular complication, especially those related to nursing care. The study was conducted in the ICU of a university hospital. Methods for estimating and analyzing medical records were used. The patient’s evaluation sheet covering 12 categories of risk factors for eye complications was worked out. The study group included 76 patients (34 patients with injuries and 42 without injuries). The Shapiro–Wilk test, the Spearman’s rank correlation test, the Mann–Whitney U test and the Friedman’s ANOVA test were used. The level of significance was set at α = 0.05. The most important risk factors for eye complications in the study group were: lagophthalmos (p < 0.001), sedation (p < 0.01), use of some cardiological drugs and antibiotics (p < 0.01), mechanical ventilation (p < 0.05), use of an open suctioning system (p < 0.01), presence of injuries (p < 0.01) including craniofacial trauma (p < 0.001), high level of care intensity (p < 0.01), failure to follow eye care protocol (p < 0.001), length of hospitalization at the ICU (p < 0.001), and the frequency of ophthalmological consultations (p < 0.001). There was no correlation between the incidence of these complications and the age and gender of the patients. The exposure of critically ill patients to eye complications was high. It is necessary to disseminate protocols and guidelines for eye care in ICU patients to reduce the risk factors.

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