Ocular Siderosis

Weiss, Michael J.; Hofeldt, Albert J.; Behrens, Myles M.; Fisher, Keith

doi:10.1097/00006982-199703000-00004

Cited by 50 publications

(18 citation statements)

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“…Macrophage activity is closely related to the mechanism and prognosis of ocular siderosis. According to previous studies, vision may be excellent in siderosis with ERG amplitudes of up to 50%, and complete reversal is possible following successful removal of the intraocular foreign body in the early stages of the condition and with amplitudes of up to 40% [8, 11]. Over this limit, macrophage activity may be overwhelmed by the amount of iron load, leading to direct cellular toxicity [4].…”

Section: Discussionmentioning

confidence: 99%

Siderotic cataract with no signs of intraocular foreign body

Zhang

Lü

et al. 2017

BMC Ophthalmol

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BackgroundOcular siderosis is a clinical condition induced by deposition of an iron-containing intraocular foreign body. We report a unique case of histopathologically proven lens siderosis in a young woman with a preceding history of trauma but no signs of retained intraocular foreign body.Case presentationA 32-year-old woman presented with an opacified lens showing brownish deposits on the anterior capsule and underwent cataract surgery. Preoperative ophthalmic examination did not show any retained intraocular foreign body. Histopathologic staining of the anterior capsule confirmed the presence of iron deposits and macrophages. Electroretinography examination performed in the postoperative period showed the changes characteristic of retinal degeneration in ocular siderosis.ConclusionThis case illustrates the importance of close monitoring of patients with a history of trauma or previous penetrating injury to the eye, even if there is no intraocular foreign body, because they might develop ocular siderosis at a later stage. This case report underscores the importance of electroretinography and histopathologic analysis, in addition to ophthalmic examination, in the diagnosis of ocular siderosis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12886-017-0424-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Siderotic cataract with no signs of intraocular foreign body

Zhang

Lü

et al. 2017

BMC Ophthalmol

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“…Ocular toxicity of an iron-containing foreign body that is retained and even located in the orbit after an injury may produce ocular siderosis and severe progressive visual loss [ 10 , 11 ]. Gerkowicz et al [ 12 ] studied the penetration of iron and found that iron passes from the orbit into the eyeball and accumulates in considerable quantities in the sclera, choroid, retina, ciliary body, and even in the vitreous and corneal epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical manifestations include a rust-colored corneal stroma, heterochromia iridis, pupillary mydriasis, uveitis, cataract, lens subluxation, secondary glaucoma, and retinal degeneration. The electroretinogram may be normal or hypernormal early in the disease process, but it gradually decreases in amplitude as the disease progresses [ 10 , 11 ]. Therefore, an exploratory surgery over the suspected area and complete removal of the foreign body by the emergency physician is necessary before the wounds have been sutured.…”

Section: Discussionmentioning

confidence: 99%

Missed Diagnosis of an Intraorbital Foreign Body of Homemade Fireworks Origin: A Case Report

Zhou

Niu

et al. 2015

Case Rep Ophthalmol

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Purpose: We report a rare case of traumatic injury to the eye caused by homemade fireworks in a Chinese juvenile patient with a metal ring left in the orbit after having been sutured at the Emergency Department. Methods: An 11-year-old boy presented with a traumatic injury to the right eye from homemade fireworks. Following initial assessment involving maxillofacial computed tomography (CT) and suturing at the Emergency Department, he was transferred to our department for further evaluation because of his poor sight 1 day later. On examination, a skin laceration beneath the right eyebrow was noted, but the superior orbit was not fully visible on the maxillofacial CT performed 1 day previously. Therefore, an orbital CT scan was carried out on the second day, which showed a hyperdense ring embedded in the superior border of the orbital wall; the ring was surgically removed. On postoperative day 7, a fundus examination revealed resolving vitreous hemorrhage, blunt traumatic retinal detachment, and a large retinal tear superior to the macula. The patient refused to take surgery for retinal detachment into consideration. Therefore, we opted for oral steroids and careful observation. Results: After 2 months' observation, the large retinal tear had healed and white fibrous scar tissue had developed, and the retinal detachment superior to the macula had reattached itself spontaneously. The patient's vision had further improved to 20/200. During 1 year of follow-up, he remained clinically stable. Conclusion: To avoid missing the diagnosis, a complete history of the mechanism of injury and accurate imaging still prove most useful. Complete removal of the foreign body by the emergency physician is necessary because of the ocular toxicity of an iron-containing foreign body. As evidenced by the current case, oral steroids and observation for a period of several months is a management of choice for traumatic retinal detachment and retinal tear superior to the macula associated with homemade fireworks in children.

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“…The electroretinogram (ERG) is the most common means of detecting ocular siderosis [1, 2, 3, 4, 5, 6, 7, 8, 9]. However, there are a few reports describing individual rod and cone ERGs in patients with ocular siderosis [5, 6, 9].…”

Section: Introductionmentioning

confidence: 99%

Electroretinographic Assessment of Early Changes in Ocular Siderosis

et al. 2000

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We examined a patient with an iron intraocular foreign body and recorded electroretinograms (ERGs) before and after the removal of the foreign body by vitrectomy. The amplitudes of the rod and cone ERGs and the oscillatory potentials (OPs) in the injured eye were reduced before the operation. In addition, the photopic on-responses (b wave) were more reduced than off-responses (d wave). One year after surgery, the amplitudes of the rod, cone and photopic on- and off-responses were markedly improved to within the low normal limit. However, the OP amplitudes remained unchanged with lower values. These findings suggest that iron retinotoxicity leads to a dysfunction of all layers but the changes may be reversible in the early period of the disease. The late period iron toxicity produces more severe damage to the inner retina than the outer retina.

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Ocular Siderosis

Cited by 50 publications

References 0 publications

Siderotic cataract with no signs of intraocular foreign body

Siderotic cataract with no signs of intraocular foreign body

Missed Diagnosis of an Intraorbital Foreign Body of Homemade Fireworks Origin: A Case Report

Electroretinographic Assessment of Early Changes in Ocular Siderosis

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