Ocular signs and symptoms of orthokeratology patients associated with povidone iodine-based disinfecting solution

Cho, Pauline; Boost, Maureen; Cheung, Sin Wan

doi:10.1016/j.clae.2022.101742

Cited by 3 publications

(3 citation statements)

References 56 publications

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“…19,35 Moreover, in addition to its low 500 ppm concentration and high biocompatibility, the PVP-I system has the following innovative advantages over MPDS and HP systems: no reports of bacterial resistance resulting from genetic changes, 36,37 no increase in antibacterial resistance because of the absence of plasmid-mediated transfer, 38 no effect on indigenous bacteria, 39 and no ocular damage because of inadequate or failed neutralization of the solution. In in vivo studies evaluating the effect of PVP-I system on ocular surface, Cho et al 22 reported that the use of the PVP-I system for rigid lenses for patients with myopia (aged 6-10 years old) did not increase corneal staining or subjective symptoms compared with before wearing orthokeratology lenses. Tan et al investigated the effects of the PVP-I system for SCL wearers (aged 18-60 years) on ocular surface and reported that corneal staining significantly decreased when using the PVP-I system compared with habitual disinfecting solutions.…”

Section: Role Of Povidone-iodine Solutionmentioning

confidence: 99%

“…20 Kobayashi et al conducted a study to assess the efficacy of eight types of MPDSs (PHMB or Polyquad based), HP systems (Concept One-Step and AOSEPT), and the PVP-I system (Bioclen FR) against trophozoites, 1-week-old cysts, and 2-week-old cysts of A. castellanii (ATCC 50514 and ATCC 50370 strains). For ATCC 50514 strain, the PVP-I system showed Frequency of contaminated cases by gramnegative bacteria PVP-I system.MPDS or HP system Cho et al 22 Corneal staining Conjunctival injection Follicles lower eyelid Subjective symptom PVP-I system cleadew GP Corneal staining and subjective symptoms were not recognized as significant changes after wearing orthokeratology lenses Conjunctival injection and follicles in lower tarsal conjunctiva were reduced significantly PVP-I, povidone-iodine; HP, hydrogen peroxide; MPDS, multipurpose disinfecting solution; SCL, soft contact lens; PHMB, polyhexamethylene biguanide.…”

Section: Anti-acanthamoeba Properties Of Povidone-iodine Solutionmentioning

confidence: 99%

“…6 The PVP-I system also exhibited strong broadspectrum antimicrobial activity and was safe. [19][20][21][22] The PVP-I system is an innovative disinfecting solution compared with an MPDS from the perspective of disinfecting efficacy, including stand-alone tests, biofilm, and lens surface or lens case contamination. 6,[23][24][25] Thus, in Japan, PVP-I system for rigid lenses is currently recommended for the care of orthokeratology lenses in the orthokeratology guidelines developed by the Japan Contact Lens Society.…”

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confidence: 99%

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Advances in Contact Lens Care Solutions: PVP-I Disinfectant and HAD Wetting Agents From Japan

Itokawa,

Yamasaki,

Suzuki

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Half of the individuals who wear contact lenses use reusable lenses that require proper care. Improper contact lens (CL) care and using inadequate disinfecting solutions can lead to lens contamination, CL-related microbial keratitis, and Acanthamoeba keratitis. Oxidative disinfecting solutions, such as hydrogen peroxide, show higher efficacy than multipurpose solutions. Povidone–iodine (PVP-I), an oxidative disinfectant used in ophthalmic surgery, has been proven to be safe and effective. The PVP-I system, a CL disinfecting solution developed in Japan, has demonstrated excellent antimicrobial and antiviral properties. Although CL discomfort does not have a risk of ocular disorders with poor visual prognosis, such as keratitis, CL discomfort can still lead to lens dropout and thus needs to be addressed. To mitigate CL discomfort, it is essential to use disinfecting solutions containing surfactants and wetting agents that improve wettability of the lens surface. A CL solution containing hyaluronic acid derivatives (HADs) as wetting agents that permanently adhere to the lens surface to improve wettability of the lens surface was developed in Japan. There is potential for HAD to be integrated into various solutions. This article reviews the efficacy of novel PVP-I–based disinfecting solution and HAD wetting agents.

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Section: Role Of Povidone-iodine Solutionmentioning

confidence: 99%

Section: Anti-acanthamoeba Properties Of Povidone-iodine Solutionmentioning

confidence: 99%

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confidence: 99%

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Advances in Contact Lens Care Solutions: PVP-I Disinfectant and HAD Wetting Agents From Japan

Itokawa,

Yamasaki,

Suzuki

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Scoping review: Reporting characteristics for the safety of contact lenses in the pediatric population

Tomiyama,

Kobia-Acquah,

Ansari

et al. 2024

Optom Vis Sci

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SIGNIFICANCE Contact lenses are an increasingly popular option for correcting pediatric refractive error due to increased awareness of interventions to slow myopia progression. With limited information on the safety profiles of contact lenses in children, it is important to characterize the current understanding and promote this device's safe and effective use. PURPOSE This scoping review evaluates characteristics of the current literature that have examined the safety of contact lenses in pediatric patients. It provides future directions for systematic reviews and identifies any gaps in the current literature or areas for future research. METHODS Literature searches in MEDLINE via PubMed, EMBASE, The Cochrane Library, trial registries, and U.S. Food and Drug Administration clinical trial documentation were performed. Included studies (i.e., experimental and quasi-experimental studies; observational studies including prospective and retrospective cohort, case-control, and analytical cross-sectional studies, and case series of 30 or more participants) reported safety and/or complications of the use of any contact lens for correcting refractive error in children (0 to 18 years). Two independent reviewers first screened the titles and abstracts, and then full-text reports for eligibility. Conflicts in eligibility were resolved by discussions with a third reviewer. Two independent reviewers extracted data, including details about the participants, context, study methods, and key findings relevant to the review question. RESULTS This scoping review included 73 studies from 10 countries using different contact lens modalities, primarily orthokeratology and soft contact lenses, in children (6 to 18 years). The most common adverse event reported by the studies was corneal staining (60% orthokeratology, 45% soft contact lens). CONCLUSIONS The need for uniform reporting standards for adverse events poses challenges for comprehensive data synthesis. However, this scoping review identified a sufficient number of studies for a future systematic review to quantify the risks associated with orthokeratology and soft contact lens use in children.

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Myopia control with orthokeratology lenses. A 3‐year follow‐up study including a cross‐over design: Clinical study Of Near‐sightedness; TReatment with Orthokeratology Lenses 2 (CONTROL2 study)

Jakobsen,

Høeg,

Møller

2024

Acta Ophthalmologica

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PurposeThe purpose of this study is to investigate 3‐year efficacy of orthokeratology lenses (OKL) in controlling axial length progression in myopic Scandinavian children. Through a cross‐over design of the control group to compare the treatment efficacy in younger versus older children, with the latter having higher cycloplegic spherical refractive error (cSEQ) at treatment initiation. Further, the study aimed to evaluate the safety of the treatment.MethodsThis was a continuation of the randomized controlled study Clinical study Of Near‐sightedness; TReatment with Orthokeratology Lenses (CONTROL study) in which the follow‐up period of the original intervention group, that received OKL, was extended from 18 months to 36 months. Meanwhile, the original control group was crossed‐over to OKL after the 18‐month follow‐up visit and treated for 18 months. Biometry was measured using Lenstar LS900, and contact lens complications were graded according to Efron Grading Scale for Contact Lens Complications (Efron score). Mixed models were used for statistical analysis.ResultsNineteen subjects in the OKL group and 28 in the control group completed the CONTROL study. Hereof, 17 and 24 subjects from the OKL group and control group, respectively, agreed to participate in the CONTROL2 study. In the OKL continue group, the treatment efficacy did not decline during the 3‐year study period (p‐values for follow‐up visits were all ≥0.82). There was no statistically significant difference between treatment efficacy when OKL treatment was initiated in younger versus older children (p‐value ≥0.14 for all follow‐up visits). Low‐grade corneal staining was seen in several subjects at some point during the study, but here were no treatment‐requiring or sight‐threatening adverse events during the study period.ConclusionThe efficacy of myopia control by OKL was stable during 3 years of treatment. Similar treatment efficacies were found regardless of the age at treatment initiation. No severe adverse events occurred during the study period.

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Ocular signs and symptoms of orthokeratology patients associated with povidone iodine-based disinfecting solution

Cited by 3 publications

References 56 publications

Advances in Contact Lens Care Solutions: PVP-I Disinfectant and HAD Wetting Agents From Japan

Advances in Contact Lens Care Solutions: PVP-I Disinfectant and HAD Wetting Agents From Japan

Scoping review: Reporting characteristics for the safety of contact lenses in the pediatric population

Myopia control with orthokeratology lenses. A 3‐year follow‐up study including a cross‐over design: Clinical study Of Near‐sightedness; TReatment with Orthokeratology Lenses 2 (CONTROL2 study)

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