Ocular surface lubricants

Bielory, Leonard; Wagle, Preeti

doi:10.1097/aci.0000000000000392

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…HA is a well investigated polymer in the ophthalmic field. HA is the highest-selling artificial tear ingredient 17 . The epithelial healing and anti-inflammatory effect of HA has been repeatedly reported 18 , 19 .…”

Section: Discussionmentioning

confidence: 99%

Moxifloxacin releasing intraocular implant based on a cross-linked hyaluronic acid membrane

Kim

Jung

Park

et al. 2021

Sci Rep

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Intraocular antibiotic delivery is an important technique to prevent bacterial infection after ophthalmic surgery, such as cataract surgery. Conventional drug delivery methods, such as antibiotic eye drops, have limitations for intraocular drug delivery due to the intrinsic barrier effect of the cornea. Therefore, frequent instillation of antibiotic eyedrops is necessary to reach a sufficient bactericidal concentration inside the eye. In this study, an intraocular implant, MXF-HA, that combines hyaluronic acid (HA) and moxifloxacin (MXF) was developed to increase the efficiency of intraocular drug delivery after surgery. MXF-HA is manufactured as a thin, transparent, yellow-tinted membrane. When inserted into the eye in a dry state, MXF-HA is naturally hydrated and settles in the eye, and the MXF contained therein is delivered by hydrolysis of the polymer over time. It was confirmed through in vivo experiments that MXF delivery was maintained in the anterior chamber of the eye at a concentration sufficient to inhibit Pseudomonas aeruginosa and Staphylococcus aureus for more than 5 days after implantation. These results suggest that MXF-HA can be utilized as a potential drug delivery method for the prevention and treatment of bacterial infections after ophthalmic surgery.

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Section: Discussionmentioning

confidence: 99%

Moxifloxacin releasing intraocular implant based on a cross-linked hyaluronic acid membrane

Kim

Jung

Park

et al. 2021

Sci Rep

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“…Lubricin is a mucin-like proteoglycan that has been found in various tissue compartments, including synovial fluid [151] and the eyes [152]. Many in vitro and in vivo studies have found lubricin to have anti-adhesive and anti-inflammatory properties [153].…”

Section: Lubricinmentioning

confidence: 99%

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

et al. 2021

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Post-operative adhesions affect patients undergoing all types of surgeries. They are associated with serious complications, including higher risk of morbidity and mortality. Given increased hospitalization, longer operative times, and longer length of hospital stay, post-surgical adhesions also pose a great financial burden. Although our knowledge of some of the underlying mechanisms driving adhesion formation has significantly improved over the past two decades, literature has yet to fully explain the pathogenesis and etiology of post-surgical adhesions. As a result, finding an ideal preventative strategy and leveraging appropriate tissue engineering strategies has proven to be difficult. Different products have been developed and enjoyed various levels of success along the translational tissue engineering research spectrum, but their clinical translation has been limited. Herein, we comprehensively review the agents and products that have been developed to mitigate post-operative adhesion formation. We also assess emerging strategies that aid in facilitating precision and personalized medicine to improve outcomes for patients and our healthcare system.

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“…70,71 Medications Topical therapies for ocular allergy are outlined in Table 5, Table 6 and Table 7. [70][71][72][73][74][75][76][77][78][79][80][81]…”

Section: Avoidance and Nonpharmacologic Measuresmentioning

confidence: 99%

The spectrum of allergic ocular diseases

Rodrigues

Kuruvilla

Vanijcharoenkarn

et al. 2021

Annals of Allergy, Asthma & Immunology

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Ocular allergy is recognized as a heterogeneous collection of immunoglobulin E (IgE) and noneIgE-mediated diseases. IgE-mediated ocular allergies include seasonal allergic conjunctivitis, perennial allergic conjunctivitis, 1 vernal keratoconjunctivitis, and atopic keratoconjunctivitis. NoneIgE-mediated ocular allergies and hypersensitivities include contact blepharoconjunctivitis, giant papillary conjunctivitis, irritative conjunctivitis, and blepharitis.The following 4 cardinal symptoms characterize ocular allergies: redness, itchiness, swelling, and watering (tearing), with several symptoms overlapping with dry eye disease.Allergological workup (skin prick testing, serum-specific IgE measurements, conjunctival provocation testing, and patch testing) is helpful in confirming a causative allergic mechanism.Newer topical corticosteroid formulations such as loteprednol have not been found to increase the risk of cataracts unlike older corticosteroids.Successful treatment usually involves a combination of avoidance of allergic triggers, medications (topical, oral, or both), and in some cases, allergy immunotherapy.

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Ocular surface lubricants

Cited by 9 publications

References 24 publications

Moxifloxacin releasing intraocular implant based on a cross-linked hyaluronic acid membrane

Moxifloxacin releasing intraocular implant based on a cross-linked hyaluronic acid membrane

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

The spectrum of allergic ocular diseases

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