2023
DOI: 10.3390/v15020354
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Ocular Symptoms Associated with COVID-19 Are Correlated with the Expression Profile of Mouse SARS-CoV-2 Binding Sites

Abstract: The COVID-19 pandemic has engendered significant scientific efforts in the understanding of its infectious agent SARS-CoV-2 and of its associated symptoms. A peculiar characteristic of this virus lies in its ability to challenge our senses, as its infection can lead to anosmia and ageusia. While ocular symptoms, such as conjunctivitis, optic neuritis or dry eyes, are also reported after viral infection, they have lower frequencies and severities, and their functional development is still elusive. Here, using c… Show more

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Cited by 2 publications
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“…[ 39 ] Increasing evidence supports the hypothesis that SARS-CoV-2 may invade the human body through the eyes [ 40 ] although there are inconsistent conclusions on whether the SARS-CoV-2 receptor ACE2 is more expressed in the conjunctiva or optic nerve. [ 41 43 ] Furthermore, it is verified that the activation of intrinsic ACE2 is a potential therapeutic strategy to treat glaucoma, [ 44 ] at the same time, drugs targeting ACE2 receptors can be considered as therapeutic candidates for COVID-19 treatment. [ 45 , 46 ] However, COVID-19 is thought to be a cause of vascular complications.…”
Section: Discussionmentioning
confidence: 99%
“…[ 39 ] Increasing evidence supports the hypothesis that SARS-CoV-2 may invade the human body through the eyes [ 40 ] although there are inconsistent conclusions on whether the SARS-CoV-2 receptor ACE2 is more expressed in the conjunctiva or optic nerve. [ 41 43 ] Furthermore, it is verified that the activation of intrinsic ACE2 is a potential therapeutic strategy to treat glaucoma, [ 44 ] at the same time, drugs targeting ACE2 receptors can be considered as therapeutic candidates for COVID-19 treatment. [ 45 , 46 ] However, COVID-19 is thought to be a cause of vascular complications.…”
Section: Discussionmentioning
confidence: 99%