Ocular temperature elevation induced by threshold<i>in vivo</i>exposure to 1090-nm infrared radiation and associated heat diffusion

Yu, Zhu Liang; Schulmeister, Karl; Talebizadeh, Nooshin; Kronschläger, Martin; Söderberg, Per G.

doi:10.1117/1.jbo.19.10.105008

Cited by 10 publications

(13 citation statements)

References 15 publications

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“…18,19 The current findings that 96-W∕cm 2 1090-nm IRR with 1-h exposure does not result in direct damage in the lens if the temperature rise is <8°C implicates that IRR-induced cataract is caused by indirect heat absorption in tissues surrounding the lens or, alternatively, possibly by a local inflammatory reaction induced by temperature rise in tissues surrounding the lens, or both.…”

Section: Discussionmentioning

confidence: 95%

“…19 In the current experiment, we chose to record temperature at the limbus only to allow for high accuracy without any risk for mechanical cataract induction.…”

Section: Discussionmentioning

confidence: 99%

“…For each animal, the measured temperature increase, ΔT (°C), at increasing time, t (s), after exposure was fitted with an exponential model 19 [Eq. (1)], rendering the asymptote maximum temperature increase, ΔT Max (°C), and the rate constant, k (s −1 ), for each animal:…”

Section: Temperature Evolutionmentioning

confidence: 99%

“…Previously, we found that 197 W∕cm 2 1090-nm IRR exposure on the cornea within the dilated pupil for a minimum of 8 s induces cataract with a temperature increase of 10°C in the anterior segment of the eye. 18,19 The purpose of the present study was to investigate if the previously suggested photochemical threshold for near-IRR induced cataract, 1.4 kJ∕cm 2 , 7,14,15 is consistent with irradiance-exposure duration reciprocity, indicating a photochemical nature of cataract formation.…”

mentioning

confidence: 99%

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Temperature-controlledin vivoocular exposure to 1090-nm radiation suggests that near-infrared radiation cataract is thermally induced

Schulmeister

Talebizadeh

et al. 2015

J. Biomed. Opt

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Abstract. The damage mechanism for near-infrared radiation (IRR) induced cataract is unclear. Both a photochemical and a thermal mechanism were suggested. The current paper aims to elucidate a photochemical effect based on investigation of irradiance-exposure time reciprocity. Groups of 20 rats were unilaterally exposed to 96-W∕cm 2 IRR at 1090 nm within the dilated pupil accumulating 57, 103, 198, and 344 kJ∕cm 2 , respectively. Temperature was recorded at the limbus of the exposed eye. Seven days after exposure, the lenses were macroscopically imaged and light scattering was quantitatively measured. The average maximum temperature increases for exposure times of 10, 18, 33, and 60 min were expressed as 7.0 AE 1.1, 6.8 AE 1.1, 7.6 AE 1.3, and 7.4 AE 1.1°C [CI (0.95)] at the limbus of the exposed eye. The difference of light scattering in the lenses between exposed and contralateral not-exposed eyes was 0.00 AE 0.02, 0.01 AE 0.03, −0.01 AE 0.02, and −0.01 AE 0.03 transformed equivalent diazepam concentration (tEDC), respectively, and no apparent morphological changes in the lens were observed. An exposure to 96-W∕cm 2 1090-nm IRR projected on the cornea within the dilated pupil accumulating radiant exposures up to 344 kJ∕cm 2 does not induce cataract if the temperature rise at the limbus is <8°C. This is consistent with a thermal damage mechanism for IRR-induced cataract. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Discussionmentioning

confidence: 95%

“…19 In the current experiment, we chose to record temperature at the limbus only to allow for high accuracy without any risk for mechanical cataract induction.…”

Section: Discussionmentioning

confidence: 99%

Section: Temperature Evolutionmentioning

confidence: 99%

mentioning

confidence: 99%

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Temperature-controlledin vivoocular exposure to 1090-nm radiation suggests that near-infrared radiation cataract is thermally induced

Schulmeister

Talebizadeh

et al. 2015

J. Biomed. Opt

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“…28 In a follow-up experiment with the same exposure conditions, temperature measurements at the limbus and close to the optic nerve outside the sclera during the exposure demonstrated that the temperature increase at the limbus was around 10°C, supporting a thermally induced short delay onset damage. 29 In a subsequent experiment, exposures with the 1090 nm beam at 96 W/cm 2 in a 2 mm spot inside the dilated pupil of a living rat eye was delivered to different groups of animals with incrementing exposure time in the interval 10-60 min, the maximum radiant exposure corresponding to a radiant exposure dose of 340 kJ/cm 2 . One eye was exposed and the contralateral eye was kept not exposed as a control.…”

Section: Recent Experimental Investigation Of Near Irr Cataractmentioning

confidence: 99%

Does infrared or ultraviolet light damage the lens?

Söderberg

Talebizadeh

et al. 2016

Eye

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In daylight, the human eye is exposed to long wavelength ultraviolet radiation (UVR), visible radiation and short wavelength infrared radiation (IRR). Almost all the UVR and a fraction of the IRR waveband, respectively, left over after attenuation in the cornea, is absorbed in the lens. The time delay between exposure and onset of biological response in the lens varies from immediate-to-short-to-late. After exposure to sunlight or artificial sources, generating irradiances of the same order of magnitude or slightly higher, biological damage may occur photochemically or thermally. Epidemiological studies suggest a dosedependent association between short wavelength UVR and cortical cataract. Experimental data infer that repeated daily in vivo exposures to short wavelength UVR generate photochemically induced damage in the lens, and that short delay onset cataract after UVR exposure is photochemically induced. Epidemiology suggests that daily high-intensity short wavelength IRR exposure of workers, is associated with a higher prevalence of age-related cataract. It cannot be excluded that this effect is owing to a thermally induced higher denaturation rate. Recent experimental data rule out a photochemical effect of 1090 nm in the lens but other wavelengths in the near IRR should be investigated.

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Ultraviolet radiation oxidative stress affects eye health

Ivanov

Mappes

Schaupp

et al. 2018

Journal of Biophotonics

152

132

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In the eye, ultraviolet radiation (UVR) is not known to contribute to visual perception but to mainly damage multiple structures. UVR carries higher energy than visible light and high dose exposure to UVR causes direct cellular damage, which has an important role in the development of cancer. This review provides an overview on the most recent knowledge on the role of UVR in oxidative stress (OS) in relation to noncancer ocular pathologies: various corneal pathologies, cataract, glaucoma and age-related macular degeneration. Possible OS signaling streams and mechanisms in the aging eye are discussed. Excessive exposure to UVR through live may seriously contribute to increase in OS of various eye tissues and thus lead to the advancement of serious ocular pathologies. Children are especially vulnerable to UVR because of their larger pupils and more transparent ocular media: up to 80% of a person's lifetime exposure to UVR is reached before the age of 18. Therefore, efficient everyday protection of the sensitive tissues of the eye by wearing of sunglasses, clear UVR-blocking spectacles or contact lenses should be considered from early age on. Many initiatives are taken worldwide to inform and raise the population's awareness about these possible UVR hazards to the eye.

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Ocular temperature elevation induced by thresholdin vivoexposure to 1090-nm infrared radiation and associated heat diffusion

Cited by 10 publications

References 15 publications

Temperature-controlledin vivoocular exposure to 1090-nm radiation suggests that near-infrared radiation cataract is thermally induced

Temperature-controlledin vivoocular exposure to 1090-nm radiation suggests that near-infrared radiation cataract is thermally induced

Does infrared or ultraviolet light damage the lens?

Ultraviolet radiation oxidative stress affects eye health

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