Ocular Toxicity of Vitreal Pluronic Polyol F-127

Davidorf, Frederick H.; Chambers, Robert B.; Kwon, Oh Woong; Doyle, William H.; Gresak, Paula; Frank, Sylvan G.

doi:10.1097/00006982-199010000-00013

Cited by 40 publications

(31 citation statements)

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“…The Pluronic F127 has displayed low toxicity in several reports [35]–[37]; however, Davidorf et al reported that the Pluronic F127 can induce retinal toxicity [38]. The authors showed the destruction of the retinal histology in Pluronic F127 injected eyes.…”

Section: Resultsmentioning

confidence: 98%

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Study In Vivo Intraocular Biocompatibility of In Situ Gelation Hydrogels: Poly(2-Ethyl Oxazoline)-Block-Poly(ε-Caprolactone)-Block-Poly(2-Ethyl Oxazoline) Copolymer, Matrigel and Pluronic F127

et al. 2013

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The long term in vivo biocompatibility is an essential feature for the design and development of sustained drug release carriers. In the recent intraocular drug delivery studies, hydrogels were suggested as sustained release carriers. The biocompatibility test for these hydrogels, however, was commonly performed only through in vitro cell culture examination, which is insufficient before the clinical applications. We compared three thermosensitive hydrogels that have been suggested as the carriers for drugs by their gel-solution phase-change properties. A new block terpolymer (PEOz-PCL-PEOz, ECE) and two commercial products (Matrigel® and Pluronic F127) were studied. The results demonstrated that the ocular media remained translucent for ECE and Pluronic F127 in the first 2 weeks, but cataract formation for Matrigel occurred in 2 weeks and for Pluronic F127 in 1 month, while turbid media was observed for both Matrigel and Pluronic F127 in 2 months. The electrophysiology examinations showed significant neuroretinal toxicity of Matrigel and Pluronic F127 but good biocompatibility of ECE. The neuroretinal toxicity of Matrigel and Pluronic F127 and superior biocompatibility of ECE hydrogel suggests ECE as more appropriate biomaterial for use in research and potentially in intraocular application.

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Section: Resultsmentioning

confidence: 98%

“…The result showed that Pluronic F127 markedly destruct the neuroretinal tissue within 2 weeks after injection [38]. Hyun et al observed that Pluronic F127 loses its original shape within one day of the subcutaneous injection [29].…”

Section: Resultsmentioning

confidence: 99%

Study In Vivo Intraocular Biocompatibility of In Situ Gelation Hydrogels: Poly(2-Ethyl Oxazoline)-Block-Poly(ε-Caprolactone)-Block-Poly(2-Ethyl Oxazoline) Copolymer, Matrigel and Pluronic F127

et al. 2013

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“…Temperature-responsive polymers often contain hydrophobic domains that allow for the inclusion of hydrophobic drugs (for example, doxorubicin) 43 . However, challenges exist for these systems, such as their relatively low mechanical strength, poor physical stability, and synthetic polymers such as PNIPAm may be non-biodegradable 44 . The stability of temperature-responsive systems may be improved by adding additional covalent cross-links after initial gelation 45,46 .…”

Section: Macroscopic Design and Delivery Routesmentioning

confidence: 99%

Designing hydrogels for controlled drug delivery

2016

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Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel–drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.

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“…It could form a gel at 21°C but it shows severe retinal toxicity making it unsuitable for clinical use [98, 99]. …”

Section: Experimental Substitutesmentioning

confidence: 99%

Vitreous Substitutes: The Present and the Future

Donati

Caprani

Airaghi

et al. 2014

BioMed Research International

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Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.

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Ocular Toxicity of Vitreal Pluronic Polyol F-127

Cited by 40 publications

References 0 publications

Study In Vivo Intraocular Biocompatibility of In Situ Gelation Hydrogels: Poly(2-Ethyl Oxazoline)-Block-Poly(ε-Caprolactone)-Block-Poly(2-Ethyl Oxazoline) Copolymer, Matrigel and Pluronic F127

Study In Vivo Intraocular Biocompatibility of In Situ Gelation Hydrogels: Poly(2-Ethyl Oxazoline)-Block-Poly(ε-Caprolactone)-Block-Poly(2-Ethyl Oxazoline) Copolymer, Matrigel and Pluronic F127

Designing hydrogels for controlled drug delivery

Vitreous Substitutes: The Present and the Future

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