Ocular Toxocariasis Presenting as Leukocoria in a Patient with Low ELISA Titer to Toxocara canis

Searl, Steven S; Moazed, Kambiz Thomas; Albert, Daniel M.; Marcus, Leonard C.

doi:10.1016/s0161-6420(81)34860-x

Cited by 40 publications

(11 citation statements)

References 15 publications

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“…The parasite reaches the eye via the ciliary vessels to the choroid or via the central retinal arteries to the retina. OT is typically a monocular disease of young children [ 5 ], and its clinical findings include posterior and peripheral retinochoroiditis, optic papillitis, and endophthalmitis [ 7 , 8 ]. The inflammatory response created by ocular involvement may result in epiretinal membrane formation, traction retinal detachment, and combined traction-rhegmatogenous retinal detachment [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ancillary tests include immunotesting and ultrasound biomicroscopy. Specific immunotesting is of importance but may be negative as Toxocara antigens may localize exclusively in vitreous humor [ 7 ]. Ultrasound biomicroscopy may be helpful with specific findings (pseudocystic transformation of the peripheral vitreous) in some eyes with a presumed diagnosis of peripheral toxocariasis [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

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Adult Ocular Toxocariasis Mimicking Ciliary Body Malignancy

Mansour

Abiad

Boulos

et al. 2014

Case Reports in Medicine

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Purpose. To discuss an unusual presentation of ocular toxocariasis. Methods. Case report. Results. A 40-year-old woman presented with decreased vision in the left eye with a long history of recurrent red eye from uveitis. Eosinophilia and positive ELISA titers for Toxocara canis favored the diagnosis of ocular toxocariasis. Over 3 months, an anterior scleral mass had a rapid growth raising the possibility of medulloepithelioma, which rarely can mimic uveitic syndromes. Surgical plan changed from local excision to enucleation. Histopathology demonstrated a large homogeneous mass of chronic inflammatory cells with inflammation of the overlying thinned out sclera, medial rectus insertion, and limbal cornea. The triad of peripheral granuloma, eosinophilia, and positive blood serology established the diagnosis of ocular toxocariasis. Conclusions. Ocular toxocariasis can mimic ocular malignancy such as medulloepithelioma in adults and rarely presents as an anterior scleral mass.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adult Ocular Toxocariasis Mimicking Ciliary Body Malignancy

Mansour

Abiad

Boulos

et al. 2014

Case Reports in Medicine

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“…De igual forma coincidimos con quienes señalaron que las alteraciones por este ascaridio no solo afectan la retina sino otras estructuras del polo posterior (1)(2)(3)(4)(5)(6)(7)(8)(9). Por otra parte, también se afecta el polo anterior como las observadas en cornea, cristalino y cámara anterior, donde notamos alteraciones histológicas de su citoarquitectura normal, acompañadas de edema intenso y reacción inflamatoria granulomatosa.…”

Section: Discussionunclassified

“…Es de resaltar que todas las alteraciones evidenciadas en nuestro estudio fueron observadas por lo general en ambos globos oculares pero con más intensidad en uno de ellos, hallazgos estos que contradicen las observaciones de quienes consideran la unilateralidad de las lesiones producto de la infección por Toxocara canis como la regla, con bilateralidad excepcional (9,11,12).…”

Section: Discussionunclassified

Infección experimental en ratones con larva migrans ocular

Stangogiannis

Marval²,

De³

et al. 2007

Arch Soc Esp Oftalmol

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RESUMENObjetivo: Caracterizar las posibles alteraciones histológicas en el globo ocular de ratones infectados masivamente con Toxocara canis, durante los estadios agudos y crónicos de la infección. Método: Se realizó un estudio experimental, prospectivo in vivo, con globos oculares derechos e izquierdos correspondientes a cinco grupos de cuatro ratones cada uno (dos blancos (A/J) y dos negros (C57/BL) infectados por vía endovenosa con 1.000 huevos embrionados de Toxocara canis. Los ratones fueron sacrificados de forma secuencial post infección (3-180 días), se realizó microscópica convencional e histopatología fotografiadas. Resultados: Todos los ratones mostraron algún grado de daño ocular en uno o ambos ojos. La retina era la capa más afectada con edema, hemorragia y cambios degenerativos severos. Otras alteraciones incluyeron reacción inflamatoria de la córnea, obliteración de la cámara anterior con material fibrinoide, asimismo, se evidenció cambios en la histología normal de la uvea y del cristalino. En dos ojos de ratones se encontraron segmentos de larva en la retina, sin reacción inflamatoria alrededor de ellos. ARTÍCULO ORIGINAL ABSTRACTObjective: To characterize the histologic alterations in the ocular globe of mice infected with eggs of Toxocara canis, during both the acute and chronic stages of the infection. Method: Performance of an experimental, prospective study in vivo, with right and left ocular globes [using 5 groups of 4 mice in each study; 2 white (A/J) and 2 black (C57/BL)], infected by the intravenous injection of 1000 embrionated Toxocara canis eggs. The mice were sacrificed sequentially post infection (3-180 days), the eyes evaluated by conventional microscopic techniques and the histopathology findings recorded. Results: All the mice revealed some degree of ocular damage in one or both eyes. The retina was the most affected layer with edema, hemorrhage and severe degenerative changes seen. Other alterations included inflammation of the cornea, and obliteration of the anterior chamber with fibrinoid material. We also demonstrated changes in the normal histology of the uvea and lens. In only two eyes were segments of larvae found in the retina, and in each instance there was no evidence of an inflammatory reaction around them.

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“…19 An enigma of human ocular toxocariasis has been the older age of these patients compared with the age of patients with visceral larvae migrans.20 Toxocara canis larvae have been found to live and remain motile for at least nine years in the monkey.21 19 An enigma of human ocular toxocariasis has been the older age of these patients compared with the age of patients with visceral larvae migrans.20 Toxocara canis larvae have been found to live and remain motile for at least nine years in the monkey.21…”

Section: Routes Of Toxocara Canismentioning

confidence: 99%

Toxocara canis Infection of the Eye

Watzke¹

1984

Arch Ophthalmol

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Ocular Toxocariasis Presenting as Leukocoria in a Patient with Low ELISA Titer to Toxocara canis

Cited by 40 publications

References 15 publications

Adult Ocular Toxocariasis Mimicking Ciliary Body Malignancy

Adult Ocular Toxocariasis Mimicking Ciliary Body Malignancy

Infección experimental en ratones con larva migrans ocular

Toxocara canis Infection of the Eye

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