Ocular Vaso-occlusive Disease in Primary Antiphospholipid Syndrome

Castañón, Cristina; Amigo, Mary‐Carmen; Bañales, José L.; Nava, Arnulfo; Reyes, Pedro A.

doi:10.1016/s0161-6420(95)31028-7

Cited by 94 publications

(58 citation statements)

References 18 publications

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“…[41][42][43] Overall 6-8% of patients with APS have ocular manifestations. There have been several recent comparative studies using LA and/or ACA to detect APS with many identifying an association between APS and CRVO (Table 3).…”

Section: Anti-phospholipid Syndromementioning

confidence: 99%

Central retinal vein occlusion and thrombophilia

Fegan

2002

Eye

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Section: Anti-phospholipid Syndromementioning

confidence: 99%

Central retinal vein occlusion and thrombophilia

Fegan

2002

Eye

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“…There have been many case reports on the presence of antiphospholipid antibodies in patients with central retinal vein occlusion (Pulido et al 1987;Levine et al 1988;Kleiner et al 1989;Asherson et al 1989b;Snyers et al 1990;Castanon et al 1995;Abu el Asrar et al 1996). In one study of 44 consecutive patients with central retinal vein occlusion, no correlation between antiphospholipid antibodies and central retinal vein occlusion could be detected (Glacet Bernard et al 1994).…”

mentioning

confidence: 99%

Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion

Larsson

Hillarp

Ólafsdóttir

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Background: Central retinal vein occlusion is a disease that is most common in old people, and often associated with atherosclerosis, hypertension, diabetes or glaucoma. Since these diseases are much less evident in young people, we wanted to investigate the prevalence of disorders in the most common anticoagulant proteins in a group of young patients with central retinal vein occlusion. Methods. 37 consecutive patients younger than 50 years and with a history of central retinal vein occlusion, were analysed for deficiencies of natural inhibitors of coagulation (protein C, S, and antithrombin III), plasminogen, resistance to activated protein C, and the presence of anticardiolipin or lupus anticoagulants. Results. Anticoagulant protein deficiencies were found in 4 patients (11%) and activated protein C resistance in 7 patients (19%). Anticardiolipin or lupus anticoagulants were not found in the patients. Conclusion: Activated protein C resistance and anticoagulant protein deficiencies seem to be important factors to the etiology to central retinal vein occlusion in young patients.

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“…[2][3][4][5] Iris neovascularization tends to occur early, 6 as was demonstrated in our patient. Castanon et al 3 reported a high prevalence of ocular disease in patients with primary antiphospholipid syndrome, with 88% of patients (15 out of 17 patients) demonstrating funduscopic abnormalities, and 29% of patients having vaso-occlusive retinopathy.…”

Section: Commentmentioning

confidence: 59%

“…The frequency of ocular vasoocclusive disorders in patients with this syndrome ranges from 0.5 to 8%, with the majority affecting the retinal vasculature. [2][3][4][5] Both the arterial and venous systems may be involved.…”

Section: Commentmentioning

confidence: 99%